LY 367385

Product Name: LY 367385
CAS No.: 198419-91-9
Chemical Name: LY 367385
Synonyms: LY 367385;LY367385,LY-367385;LY-367385 hydrochloride;SGIKDIUCJAUSRD-QMMMGPOBSA-N;LY 367385, mGlu1a antagonist;(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid;4-[(R)-amino(carboxy)methyl]-3-methylbenzoic acid;4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid;(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid;(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid
CBNumber: CB5200038
Molecular Formula: C10H11NO4
Formula Weight: 209.2
MOL File: 198419-91-9.mol

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LY 367385 Property

storage temp.: Desiccate at RT
solubility: H2O: >10mg/mL
form: powder
color: white to off-white
Water Solubility: H2O: 18mg/mL

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L4420
Product name: LY-367385 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Sigma-Aldrich

Product number: L4420
Product name: LY-367385 hydrochloride
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $326
Updated: 2024/03/01

Tocris

Product number: 1237
Product name: LY367385
Purity: ≥99%(HPLC)
Packaging: 50
Price: $802
Updated: 2021/12/16

Tocris

Product number: 1237
Product name: LY367385
Purity: ≥99%(HPLC)
Packaging: 10
Price: $191
Updated: 2021/12/16

TRC

Product number: L486690
Product name: LY367385
Packaging: 25mg
Price: $235
Updated: 2021/12/16

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LY 367385 Chemical Properties,Usage,Production

Uses

LY 367385 is a selective mGlu1a receptor antagonist used to treat inflammatory diseases (ie. multiple sclerosis) and neurodegenerative diseases (ie. Alzheimer’s) (1,2).

Biological Activity

A selective mGlu 1a receptor antagonist, with an IC 50 value of 8.8 μ M for blockade of quisqualate-induced phosphoinositide hydrolysis vs. > 100 μ M for mGlu 5a , and negligible action on group II and III receptors. Also available as part of the Group I mGlu Receptor Tocriset™ .

Biochem/physiol Actions

LY-367385 hydrochloride has an ability to inhibit induction of long-term potentiation (LTP).

in vitro

compared with the activity of ly367385, the novel compound ly367366 antagonizes both mglu1a and -5 receptors at low micromolar concentrations, but also recruits other subtypes at higher concentrations. ly367366 possessing neuroprotective ability was in general less efficacious than ly357385. this fact suggested that inhibitors of mglu1 receptors is a potential agent to confer significant neuroprotection [1].

in vivo

ly 367385 and aida have been administered intracerebroventricularly (i.c.v.) to lethargic mice and dbar2 mice, and focally into the inferior colliculus of gepr. in lethargic mice both compounds significantly decrease the incidence of spontaneous spike and wave discharges on the electroencephalogram, after the administration of ly 367385, 250 nmol, i.c.v. ly 367385, 50 nmol, inhibites spontaneous spike and wave discharges from 30 to 60 min. in dbar2 mice both compounds produce a rapid, transient suppression of sound-induced clonic seizures. in genetically epilepsy prone rats, both compounds decreases sound-induced clonic seizures. the results suggestes that antagonists of mglu1 receptors are potential anticonvulsant tools and that activation of mglu1 receptors likely contributes to a variety of epilepticsyndromes [2].

IC 50

8.8 μm

storage

Room temperature (desiccate)

References

[1]. bruno v, battaglia g, kingston a, o'neill mj, catania mv, di grezia r, nicoletti f. neuroprotective activity of the potent and selective mglu1a metabotropic glutamate receptor antagonist, (+)-2-methyl-4 carboxyphenylglycine (ly367385): comparison with ly357366, a broader spectrum antagonist with equal affinity for mglu1a and mglu5 receptors. neuropharmacology. 1999 feb;38(2):199-207.
[2]. chapman ag, yip pk, yap js, quinn lp, tang e, harris jr, meldrum bs. anticonvulsant actions of ly 367385 ((+)-2-methyl-4-carboxyphenylglycine) and aida ((rs)-1-aminoindan-1,5-dicarboxylic acid). eur j pharmacol. 1999 feb 26;368(1):17-24.

LY 367385 Preparation Products And Raw materials

Raw materials

Preparation Products

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LY 367385 Suppliers

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198419-91-9, LY 367385Related Search:

N,N-DIETHYLBENZAMIDE (+)-MCPG, LY367385, S(+)-α-Amino-4-carboxy-α-methyl-benzeneacetic acid (S)-AMINO-O-TOLYL-ACETIC ACID Benzenemethanol, 4-[(1R)-1-aminoethyl]- AMINO-(2,4-DIMETHYL-PHENYL)-ACETIC ACID 4-CARBOXYPHENYLACETIC ACID (RS)-4-CARBOXYPHENYLGLYCINE (1R)-1-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE-1,6-DICARBOXYLIC ACID (S)-4-CARBOXYPHENYLGLYCINE (+/-)-LY367385 (1S)-1-AMINO-1,2,3,4-TETRAHYDRONAPHTHALENE-1,6-DICARBOXYLIC ACID (R)-4-CARBOXYPHENYLGLYCINE Benzenemethanamine, α,2,4-trimethyl-, (αR)- LY 367385

(S)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID

LY 367385

(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneaceticacid

(S)-4-[aMino(carboxy)Methyl]-3-Methylbenzoic acid

(S)-(+)-a-amino-4-carboxy-2-methylbenzeneacetic acid

LY-367385 hydrochloride

SGIKDIUCJAUSRD-QMMMGPOBSA-N

(R)-(+)-alpha-Amino-4-carboxy-2-methylbenzeneacetic acid

LY-367385;(R)-(+)-ALPHA-AMINO-4-CARBOXY-2-METHYLBENZENEACETIC ACID

Benzeneacetic acid, α-amino-4-carboxy-2-methyl-, (αS)-

(S)-(+)-α-Amino-4-carboxy-2-methylbenzeneacetic acid

LY367385,LY-367385

4-[(R)-amino(carboxy)methyl]-3-methylbenzoic acid

4-[(S)-amino(carboxy)methyl]-3-methylbenzoic acid

LY 367385, mGlu1a antagonist

198419-91-9

Glutamate