ChemicalBook > CAS DataBase List > M-NIFEDIPINE

M-NIFEDIPINE

Product Name
M-NIFEDIPINE
CAS No.
21881-77-6
Chemical Name
M-NIFEDIPINE
Synonyms
BAY-a-4339;M-NIFEDIPINE;Einecs 244-628-5;Nicardipine USP RC C;Benidipine impurity D;Nicardipine Impurity89;Nitrendipine Impurity 2;Nicardipine Impurity 03;Lercanidipine Impurity F;M-Nifedipine Impurity 11
CBNumber
CB5200528
Molecular Formula
C17H18N2O6
Formula Weight
346.33
MOL File
21881-77-6.mol
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M-NIFEDIPINE Property

Melting point:
211-213℃
Boiling point:
478.1±45.0 °C(Predicted)
Density 
1.271±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
solubility 
Chloroform (Slightly, Sonicated), DMSO (Slightly), Methanol (Slightly, Heated)
form 
Solid
pka
2.71±0.70(Predicted)
color 
Off-White to Light Yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC
Product number
N457015
Product name
m-Nifedipine
Packaging
100mg
Price
$185
Updated
2021/12/16
TRC
Product number
N457015
Product name
m-Nifedipine
Packaging
1g
Price
$1455
Updated
2021/12/16
Biosynth Carbosynth
Product number
ID57942
Product name
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
Packaging
100mg
Price
$50
Updated
2021/12/16
Biosynth Carbosynth
Product number
ID57942
Product name
1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
Packaging
250mg
Price
$75
Updated
2021/12/16
AK Scientific
Product number
3185BA
Product name
M-Nifedipine
Packaging
1g
Price
$80
Updated
2021/12/16
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M-NIFEDIPINE Chemical Properties,Usage,Production

Uses

m-Nifedipine is an impurity of Nifedipine (N457000). Nicardipine USP Related Compound C.

Synthesis

99-61-6

105-45-3

21881-77-6

a) Synthesis of dimethyl 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate A mixture of 75.5 g (0.50 mol) of 3-nitrobenzaldehyde, 116 g (1.00 mol) of methyl acetoacetate, and 55 mL (1.50 mol) of 28% ammonia solution was heated to reflux for 5 hours in 150 mL of methanol. After completion of the reaction, the precipitate was collected by filtration and the filter cake was purified by washing with hot anhydrous ethanol to give 133.5 g of yellow powdery product. The melting point (determined by Kofler's method) was 208°C. The yield was 77.2%.

References

[1] Synthetic Communications, 2012, vol. 42, # 3, p. 454 - 459
[2] Heteroatom Chemistry, 2006, vol. 17, # 4, p. 267 - 271
[3] Catalysis Communications, 2015, vol. 72, p. 63 - 67
[4] Patent: CN107141249, 2017, A. Location in patent: Paragraph 0134; 0135
[5] Monatshefte fur Chemie, 2006, vol. 137, # 1, p. 77 - 81

M-NIFEDIPINE Preparation Products And Raw materials

Raw materials

Preparation Products

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21881-77-6, M-NIFEDIPINERelated Search:

Nitrendipine nifedipine(uspgrade Nitrendipine Propyl Ester 5-(Ethoxycarbonyl)-2-(hydroxyMethyl-6-Methyl-4-(3-nitrophenyl)nicotinic Acid Nifedipine Impurity F NSC 136464 Dehydronitrendipine 3-benzyloxypyridine Benidipine Impurity 6 Benidipine Impurity 22 benidipine Benidipine Impurity Benidipine Impurity 23 Benidipine Impurity 15 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3-Methyl Ester bis(1-benzylpiperidin-3-yl) 2,6-dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate Butanoic acid, 3-oxo-, 1-(phenylmethyl)-3-piperidinyl ester 1-Benzyl-3-piperidinol

  • DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDROPYRIDINE-3,5-DICARBOXYLATE
  • dimethyl 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylate
  • DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3,5-DICARBOXYLATE(LERCANIDIPINE INTERMEDIATE)
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophen yl)-, dimethyl ester
  • 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic acid dimethyl ester
  • Dimethyl-2,6-dimethyl-4(3-nitrophenyl)-1,4-dihydrpyridine- 3-5-dicarboxylate
  • DIMETHYL-2,6-DIMETHYL-4(3-NITROPHENYL)-1,4-DIHYDRPYRIDINE-3-5-DICARBOXYLATE/LERCANIDIPINEOFINTERMEDIATER-1
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester
  • 1,4-Dihydro-2,6-dimethyl-4β-(3-nitrophenyl)pyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(3-Nitrophenyl)-1,4-dihydro-2,6-dimethylpyridine-3,5-dicarboxylic acid dimethyl ester
  • 4-(3-Nitrophenyl)-2,6-dimethyl-1,4-dihydro-3,5-pyridinedicarboxylic acid dimethyl ester
  • BAY-a-4339
  • Einecs 244-628-5
  • 1,4-Dihydro-2,6-diMethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylic Acid 3,5-DiMethyl Ester
  • DiMethyl 4-(M-nitrophenyl)-2,6-diMethyl-1,4-dihydro-3,5- pyridinedicarboxylate
  • 1,4-Dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3.5-pyridinecarboxylic acid dimethyl ester
  • M-NIFEDIPINE
  • Benidipine impurity D
  • Lercanidipine Impurity F
  • Nicardipine Hydrochloride EP impurity C
  • Nicardipine USP RC C
  • Nitrendipine Impurity 2
  • Nitrendipine EP Impurity B
  • M-Nifedipine Impurity 11
  • Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B)
  • Nicardipine Impurity 3（Nicardipine EP Impurity C）
  • Nicardipine dimethyl ester
  • Dimethyl 2,6-Dimethyl-4-(3-nitrophe
  • 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-dimethyl ester
  • Nicardipin Impurity USP RC-C
  • Nitrendipine EP Impurity B (Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Lercanidipine Dimethyl Ester Impurity)
  • NICARDIPINE DIMETHYL ESTER ANALOG
  • Nicardipine Related Compound C (Nicardipine Dimethyl Ester Analog/ m-Nifedipine/ Nitrendipine EP Impurity B)
  • Lercanidipine Dimethyl Ester Impurity (Nitrendipine EP Impurity B/ Nicardipine Related Compound C/ Nicardipine Dimethyl Ester Analog/ m-Nifedipine)
  • Nicardipine Impurity89
  • Nicardipine EP Impurity C
  • Nicardipine dimethyl esterQ: What is Nicardipine dimethyl ester Q: What is the CAS Number of Nicardipine dimethyl ester Q: What is the storage condition of Nicardipine dimethyl ester Q: What are the applications of Nicardipine dimethyl ester
  • Nicardipine Related Compound C
  • NICARDIPINE DIMETHYL ESTER ALOG
  • Benidipine Impurity D(Nitrendipine EP Impurity B)
  • Nicardipine EP Impurity C (Nicardipine USP Related Compound C, Nitrendipine EP Impurity B)
  • Nicardipine EP Impurity C（Nitrendipine EP Impurity B、Benidipine impurity D、Lercanidipine Impurity F）
  • Nicardipine Hydrochloride Impurity C
  • Nitrendipine Impurity 2 (Nitrendipine EP Impurity B)
  • Nicardipine EP Impurity 3
  • Nicardipine Impurity 03
  • NICARELATED COMPOUND IPINE DIMETHYL ESTER
  • 21881-77-6
  • (intermediate of benidipine hcl)