ChemicalBook > CAS DataBase List > 15D-PGJ2
15D-PGJ2
- Product Name
- 15D-PGJ2
- CAS No.
- 87893-55-8
- Chemical Name
- 15D-PGJ2
- Synonyms
- 15D-PGJ2;15d-PGJ?;15-deoxy-Δ-12;15-deoxy-Δdelta12,14-Pgj 2;15-Deoxy-Delta12;14-Prostaglandin J2;15-Deoxy-Δ12,14-PGJ2;12,14-prostaglandin J2;15-DEOXY-DELTA12,14-PGJ2
- CBNumber
- CB5206904
- Molecular Formula
- C20H28O3
- Formula Weight
- 316.43
- MOL File
- 87893-55-8.mol
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15D-PGJ2 Property
- Flash point:
- -9℃
- storage temp.
- -20°C
- solubility
- Soluble in Methyl acetate (supplied pre-dissolved - 1mg/ml)
- form
- methyl acetate solution
- color
- Colorless to light yellow
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Safety
- Hazard Codes
- F,Xi
- Risk Statements
- 11-36/38-66-67-36
- Safety Statements
- 16-26-29-33-36/37/39
- RIDADR
- UN 1231 3/PG 2
- WGK Germany
- 1
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H225Highly Flammable liquid and vapour
H319Causes serious eye irritation
H336May cause drowsiness or dizziness
- Precautionary statements
-
P210Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- D8440
- Product name
- 15-Deoxy-Δ12,14-prostaglandin J2
- Purity
- ≥95%(HPLC),1?mg/mLinmethylacetate
- Packaging
- 100μg
- Price
- $47.4
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 538927
- Product name
- 15d-PGJ?
- Packaging
- 1mg
- Price
- $196
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- J67427
- Product name
- 15-Deoxy-delta12,14-prostaglandin J2, 97%
- Packaging
- 1mg
- Price
- $196
- Updated
- 2021/12/16
Cayman Chemical
- Product number
- 18570
- Product name
- 15-deoxy-Δ12,14-Prostaglandin J2
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $32
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 10007235
- Product name
- 15-deoxy-Δ12,14-Prostaglandin J2 MaxSpec? Standard
- Purity
- ≥95%
- Packaging
- 100μg
- Price
- $66
- Updated
- 2023/06/20
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15D-PGJ2 Chemical Properties,Usage,Production
Uses
15-Deoxy-Δ12,14-prostaglandin J2 has been used:
- to study its effect on lipid accumulation, viability/mitochondrial activity, and amount of vasculature in vascularized adipose tissue model
- as a peroxisome proliferator-activated receptor (PPARγ) agonist to activate intestinal fatty acid binding protein (I-FABP)-PPARγ pathway
- as a supplement in culture medium for induced neural stem/progenitor cells (NSPCs) differentiation
Definition
ChEBI: 15-deoxy-Delta(12,14)-prostaglandin J2 is a prostaglandin J derivative comprising prostaglandin J2 lacking the 15-hydroxy group and having C=C double bonds at the 12- and 14-positions. It has a role as a metabolite, an electrophilic reagent and an insulin-sensitizing drug. It is functionally related to a prostaglandin J2. It is a conjugate acid of a 15-deoxy-Delta(12,14)-prostaglandin J2(1-).
General Description
A metabolite of PGD2 that has recently been identified as a natural ligand for PPARγ-dependent adipogenesis in transfected 3T3 cells and for PPARγ response element (PPRE) in CV-1 cells. Competes with thiazolidinediones for PPARγ binding.
Biological Activity
Selective PPAR γ agonist that induces adipocyte differentiation in C3H10Y1/2 fibroblasts (EC 50 = 7 μ M).
Biochem/physiol Actions
15-Deoxy-Δ12,14-prostaglandin J2 (15d-PGJ2) regulates inflammatory response in vivo. 15d-PGJ2 also elicits PPARγ-independent inhibition of nuclear factor (NF)-κB dependent transcription. It acts as an anti-angiogenic factor and triggers endothelial cell apoptosis.
15D-PGJ2 Preparation Products And Raw materials
Raw materials
Preparation Products
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