ChemicalBook > CAS DataBase List > CHOLIC ACID METHYL ESTER
CHOLIC ACID METHYL ESTER
- Product Name
- CHOLIC ACID METHYL ESTER
- CAS No.
- 1448-36-8
- Chemical Name
- CHOLIC ACID METHYL ESTER
- Synonyms
- METHYL CHOLATE;NSC 126794;Methyl cholatesee;Cholic acid methyl;Methyl Cholate >Methyl cholate, 98+%;Methyl Cholate, ≥ 97.0%;CHOLIC ACID METHYL ESTER;Cholic Αcid Μethyl Εster;Methyl Cholate See C432610
- CBNumber
- CB5208377
- Molecular Formula
- C25H42O5
- Formula Weight
- 422.6
- MOL File
- 1448-36-8.mol
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CHOLIC ACID METHYL ESTER Property
- Melting point:
- 155-156°C
- Boiling point:
- 541.6±50.0 °C(Predicted)
- Density
- 1.141±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly)
- form
- Solid
- pka
- 14?+-.0.70(Predicted)
- color
- White to Off-White
- Water Solubility
- Insoluble in water. Soluble in medium polarity organic solvents.
- Merck
- 14,2203
- BRN
- 2226989
- CAS DataBase Reference
- 1448-36-8(CAS DataBase Reference)
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
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N-Bromosuccinimide Price
TRC
- Product number
- M294475
- Product name
- MethylCholate
- Packaging
- 1g
- Price
- $60
- Updated
- 2021/12/16
Matrix Scientific
- Product number
- 098798
- Product name
- Methyl cholate
- Purity
- 95+%
- Packaging
- 10g
- Price
- $76
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC58659
- Product name
- Cholic acid methyl ester
- Packaging
- 2g
- Price
- $84.38
- Updated
- 2021/12/16
AK Scientific
- Product number
- 7142AA
- Product name
- Methylcholate
- Packaging
- 25g
- Price
- $119
- Updated
- 2021/12/16
Biosynth Carbosynth
- Product number
- FC58659
- Product name
- Cholic acid methyl ester
- Packaging
- 5G
- Price
- $135
- Updated
- 2021/12/16
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CHOLIC ACID METHYL ESTER Chemical Properties,Usage,Production
Chemical Properties
Off-White Solid
Uses
Protected Cholic Acid
Uses
Methyl cholate, is used as a bile acid derivative as anti-inflammatory and antitumor agent.
Uses
A bile acid derivative as anti-inflammatory and antitumor agent.
Definition
ChEBI: Cholic Acid Methyl Ester is a bile acid.
Synthesis
67-56-1
81-25-4
1448-36-8
To a mixed toluene/methanol (30 ml, V/V=2:1) solution of cholic acid (2.0 g, 4.9 mmol) was added trimethylsilyl diazomethane (3.67 ml, 7.34 mmol), and the reaction was stirred for 2 h at 20 °C. The reaction was monitored by thin layer chromatography (TLC, spreader ratio of methanol/dichloromethane=1:10). The progress of the reaction was monitored by thin layer chromatography (TLC, spreading agent ratio methanol/dichloromethane=1:10) to confirm complete consumption of cholic acid and generation of new spots. Upon completion of the reaction, the reaction mixture was concentrated to afford (R)-methyl 4-((3R,5S,7R,8R,9S,10S,12S,13R,14S,17R)-3,7,12-trihydroxy-10,13-dimethyl-hexadecahydro-1H-cyclopenta[a]phenanthracen-17-yl)pentanoate (2.08 g, 100% yield) as a white foamy solid. Its hydrogen NMR spectrum (400MHz, CDCl3) data were as follows: δ 3.98(m, 1H, C12-H), 3.85(m, 1H, C7-H), 3.45(m, 1H, C3-H), 3.66(s, 3H, OCH3), 0.98(d, 3H, 21-Me), 0.89(s, 3H, 19-Me), 0.69 (s, 3H, 18-Me).
References
[1] Drug Metabolism and Disposition, 2017, vol. 45, # 7, p. 721 - 733
[2] Patent: WO2009/146218, 2009, A2. Location in patent: Page/Page column 141
[3] Tetrahedron Letters, 2010, vol. 51, # 1, p. 93 - 95
[4] Steroids, 2010, vol. 75, # 10, p. 701 - 709
[5] Tetrahedron Letters, 2011, vol. 52, # 52, p. 7128 - 7131
CHOLIC ACID METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from CHOLIC ACID METHYL ESTER manufacturers
Zhuozhou Wenxi import and Export Co., Ltd
- Product
- CHOLIC ACID METHYL ESTER 1448-36-8
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-06-27
Career Henan Chemical Co
- Product
- CHOLIC ACID METHYL ESTER 1448-36-8
- Price
- US $6.60-0.00/g
- Min. Order
- 500g
- Purity
- 98%
- Supply Ability
- 500G ,1KG , 100KG
- Release date
- 2019-12-23
1448-36-8, CHOLIC ACID METHYL ESTERRelated Search:
CHOLIC ACID METHYL ESTER
5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL ETHYL ESTER
METHYL DESOXYCHOLATE
(3a,5b,7a,12a)-3-Amino-7,12-dihydroxycholan-24-oic acid methyl ester
METHYL CHENODEOXYCHOLATE
HYODEOXYCHOLIC ACID METHYL ESTER
Cholic acid
Methyl3a,7a,12a-trimethacryloyloxy-5b-cholan-24-ate
Methyl 3α-methacryloyloxy-7α,12α-dihydroxy-5β-cholan-24-ate
LITHOCHOLIC ACID METHYLESTER(RG)
Methyl3a-Acryloyloxy7a,12a-dihydroxy-5b-cholan–24-ate
CHOLIC ACID METHYL ESTER(RG)
CHOLIC ACID METHYL ESTER = METHYL CHOLATE
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL 3-ETHOXYCARBONYL, METHYL ESTER
CHOLIC ACID METHYL ESTER 3,7,12-TRI-HEMISUCCINATE
CHOLIC ACID METHYL ESTER 3-TOSYLATE
5-BETA-CHOLANIC ACID-3-ALPHA, 7-ALPHA, 12-ALPHA-TRIOL 3,7-DIACETATE METHYL ESTER
5BETA-CHOLANIC ACID-3ALPHA,7ALPHA,12ALPHA-TRIOL 3-CARBETHOXYLATE METHYL ESTER