ChemicalBook > CAS DataBase List > 1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone

Product Name
1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone
CAS No.
96969-83-4
Chemical Name
1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone
Synonyms
BML-266;JFD00244;JFD00244,JFD-00244;1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone;1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione;9,10-Anthracenedione, 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-
CBNumber
CB52092329
Molecular Formula
C30H26N2O4
Formula Weight
478.54
MOL File
96969-83-4.mol
More
Less

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone Property

Boiling point:
780.2±60.0 °C(Predicted)
Density 
1.370±0.06 g/cm3(Predicted)
storage temp. 
Room temp
solubility 
DMSO: ≥10mg/mL
pka
9.76±0.15(Predicted)
form 
solid
color 
violet
More
Less

Safety

Hazard Codes 
N
Risk Statements 
50/53
Safety Statements 
60-61
RIDADR 
UN 3077 9/PG 3
WGK Germany 
3
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H400Very toxic to aquatic life

Precautionary statements

P273Avoid release to the environment.

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
14648
Product name
JFD00244
Purity
≥95%
Packaging
1mg
Price
$32
Updated
2024/03/01
Cayman Chemical
Product number
14648
Product name
JFD00244
Purity
≥95%
Packaging
5mg
Price
$70
Updated
2024/03/01
Cayman Chemical
Product number
14648
Product name
JFD00244
Purity
≥95%
Packaging
10mg
Price
$109
Updated
2024/03/01
TRC
Product number
B595908
Product name
BML-266
Packaging
1mg
Price
$45
Updated
2021/12/16
ChemScene
Product number
CS-0033891
Product name
JFD00244
Purity
>98.0%
Packaging
1mg
Price
$50
Updated
2021/12/16
More
Less

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone Chemical Properties,Usage,Production

Description

Human sirtuin 2 (SIRT2) is a NAD+-dependent protein deacetylase with diverse targets, including α-tubulin, phosphoenolpyruvate carboxykinase, and forkhead box protein O1. JFD00244 is an inhibitor of SIRT2 (IC50= 56.7 μM). At 5 μM, JFD00244 induces granulocytic differentiation in the acute promyelocytic leukemia cell line NB4.

Uses

BML-266 is an inhibitor of SIRT2.

Definition

ChEBI: 1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione is an anthraquinone.

in vitro

in a previou study, the molecular modeling and virtual screening were utilized to identify potential compounds, which were then subjected to experimental tests for their sirt2 inhibitory activity. five of the 15 tested compounds including jfd00244 displayed inhibitory activity toward sirt2, resulting in a hit ratio of 33% in a micromolar level. jfd00244 and another analog of the five compounds yielded in vitro ic(50) values of 56.7 and 74.3 microm, respectively. on the basis of these results, a phenol moiety on the active compounds including jfd00244 was suggested to be critical for sirt2 inhibitory activity. this phenol group, together with a hydrophobic moiety and hydrogen-bonding features, was thus recommended to form an active sirt2 pharmacophore [1].

IC 50

56.7 μm

References

[1] tervo aj, kyrylenko s, niskanen p, salminen a, leppnen j, nyrnen th, jrvinen t, poso a. an in silico approach to discovering novel inhibitors of human sirtuin type 2. j med chem. 2004 dec 2;47(25):6292-8.

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone Suppliers

China 31 Switzerland 1 United States 7 USA 1 Global 40
Shanghai EFE Biological Technology Co., Ltd.
Tel
021-65675885 18964387627
Fax
021-65675885
Email
info@efebio.com
Country
China
ProdList
9709
Advantage
58
Fan De(Beijing) Biotechnology Co., Ltd.
Tel
15911056312
Email
liming@bio-fount.com
Country
China
ProdList
9730
Advantage
58
ChemeGen(Shanghai) Biotechnology Co.,Ltd.
Tel
18818260767
Fax
QQ 3610331285
Email
sales@chemegen.com
Country
China
ProdList
11289
Advantage
58
MedBioPharmaceutical Technology Inc
Tel
021-69568360 18916172912
Email
order@med-bio.cn
Country
China
ProdList
8141
Advantage
58
Changzhou Furuisi Biotechnology Co., Ltd
Tel
0519-85524369
Email
3477467573@qq.com
Country
China
ProdList
8618
Advantage
58
Beijing Jin Ming Biotechnology Co., Ltd.
Tel
010-60605840
Email
psaitong@jm-bio.com
Country
China
ProdList
29778
Advantage
58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24018
Advantage
58
Shanghai Tachizaki Biomedical Research Center
Tel
18014399201
Email
sales@chemlab-tachizaki.com
Country
China
ProdList
2491
Advantage
58
RD International Technology Co., Limited
Tel
18024082417
Email
market@ubiochem.com
Country
China
ProdList
9180
Advantage
58
Beijing Baiao Innovation Technology Co., Ltd.
Tel
--
Fax
--
Email
3007606172@qq.com
Country
CHINA
ProdList
6005
Advantage
58
Shanghai Ziqi Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
2453006496@qq.com
Country
CHINA
ProdList
6192
Advantage
58
Beijing Bai Ao Si Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
yangmei@bioneeds.net
Country
CHINA
ProdList
6999
Advantage
58
Shanghai Minmin Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1914109725@qq.com
Country
CHINA
ProdList
6530
Advantage
58
Morning Student Science and Technology (Guangzhou) Co., Ltd.
Tel
--
Fax
--
Email
chenxue_gz@163.com
Country
CHINA
ProdList
6618
Advantage
58
Xiamen Research Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1562893815@qq.com
Country
CHINA
ProdList
6942
Advantage
58
Shanghai Yaoyun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
912529879@qq.com
Country
CHINA
ProdList
6852
Advantage
58
Shenzhen Xinbosheng Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
service@neobioscience.com
Country
CHINA
ProdList
6164
Advantage
58
Beijing Fubo Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
info@f-biology.com
Country
CHINA
ProdList
6039
Advantage
58
Boao Pike
Tel
--
Fax
--
Email
lyn@biopike.com.cn
Country
CHINA
ProdList
6629
Advantage
58
Guangzhou Weijia Technology Co., Ltd.
Tel
--
Fax
--
Email
WHIGA22@126.COM
Country
CHINA
ProdList
6748
Advantage
58
Beijing Bolide Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1985563437@qq.com
Country
CHINA
ProdList
6172
Advantage
58
Beijing Dongge Boye Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
1861586486@qq.com
Country
CHINA
ProdList
6652
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
shxiyuanbio@163.com
Country
CHINA
ProdList
6921
Advantage
58
Shanghai Hao Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
market@xlswkj.com
Country
CHINA
ProdList
6805
Advantage
58
Shanghai Hao Zhun Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
info@zzsrm.com
Country
CHINA
ProdList
6846
Advantage
58
Shanghai Weiwei Biological Technology Co., Ltd.
Tel
--
Fax
--
Email
sales@wheybio.com
Country
CHINA
ProdList
4398
Advantage
58
Shanghai Benrui Biotechnology Co., Ltd.
Tel
--
Fax
--
Email
john.st@163.com
Country
CHINA
ProdList
1472
Advantage
58

96969-83-4, 1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinoneRelated Search:

Acetyl-trans-resveratrol SIRTINOL Aristoforin 6-CHLORO-2,3,4,9-TETRAHYDRO-1H-CARBAZOLE-1-CARBOXAMIDE FLAVOXATE

  • 1,4-Bis[(p-hydroxyphenethyl)amino]-anthraquinone
  • JFD00244
  • BML-266
  • 1,4-bis[2-(4-hydroxyphenyl)ethylamino]anthracene-9,10-dione
  • 9,10-Anthracenedione, 1,4-bis[[2-(4-hydroxyphenyl)ethyl]amino]-
  • JFD00244,JFD-00244
  • 96969-83-4