5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
- Product Name
- 5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
- CAS No.
- 943552-31-6
- Chemical Name
- 5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
- Synonyms
- 5-Bromo-2-thiophenylboronate MIDA ester;5-Bromothiophene-2-boronic acid MIDA este;5-Bromo-2-thiophenylboronic acid MIDA ester;5-Bromo-2-thiophenylboronic acid MIDA ester 95%;5-Bromothiophene-2-boronic acid methyliminodiacetic acid ester;2-(5-bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione;8-(5-Bromothiophen-2-yl)-4-methyl-2,6-dioxohexahydro-[1,3,2]oxazaborolo[2,3-b][1,3,2]oxazaborol-4-ium-8-uide;5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione
- CBNumber
- CB52100206
- Molecular Formula
- C9H9BBrNO4S
- Formula Weight
- 317.95206
- MOL File
- 943552-31-6.mol
5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione Property
- Melting point:
- 151-156 °C
- storage temp.
- 2-8°C, stored under nitrogen
- Appearance
- Off-white to light brown Solid
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- BOR0002740
- Product name
- 5-BROMO-2-THIOPHENYLBORONIC ACID MIDA ESTER
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $674.53
- Updated
- 2021/12/16
- Product number
- A753492
- Product name
- 5-Bromo-2-thiophenylboronic acid MIDA ester
- Purity
- 95%
- Packaging
- 25g
- Price
- $1290
- Updated
- 2021/12/16
- Product number
- A753492
- Product name
- 5-Bromo-2-thiophenylboronic acid MIDA ester
- Purity
- 95%
- Packaging
- 250mg
- Price
- $35
- Updated
- 2021/12/16
- Product number
- A753492
- Product name
- 5-Bromo-2-thiophenylboronic acid MIDA ester
- Purity
- 95%
- Packaging
- 1g
- Price
- $90
- Updated
- 2021/12/16
- Product number
- A753492
- Product name
- 5-Bromo-2-thiophenylboronic acid MIDA ester
- Purity
- 95%
- Packaging
- 5g
- Price
- $305
- Updated
- 2021/12/16
5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione Chemical Properties,Usage,Production
Uses
MIDA boronates as stable boronic acid surrogates for classically challenging cross-couplings
Suzuki Cross-Coupling with MIDA Boronates
Synthesis
162607-17-2
4408-64-4
943552-31-6
The general procedure for the synthesis of 5-bromo-2-thiophene-2-boronic acid and N-methyliminodiacetic acid as raw materials for the synthesis of 5-bromo-2-thienylboronic acid methyliminodiacetic ester was as follows: (The synthetic route and products were provided by the team of Dr. Congze He from Fudan University) 5-bromothiophene-2-boronic acid (1.3 kg, 10 mol) and N-methyliminodiacetic acid (1.6 kg, 11 mol) were dissolved in a a solvent mixture of toluene and dimethyl sulfoxide (10:1, v/v) and the reaction was refluxed at 120°C for 4 hours. After completion of the reaction, it was slowly cooled to room temperature and the toluene was removed by distillation under reduced pressure. The residual solution was diluted by adding a large amount of water and a yellowish solid precipitate was precipitated. The resulting solid was dissolved in a solvent mixture of acetonitrile and dimethylformamide (5:1, v/v), and N-bromosuccinimide (1.8 kg, 10 mol) was slowly added under light protection and low temperature. The reaction mixture was stirred at room temperature overnight. At the end of the reaction, the acetonitrile was removed by distillation under reduced pressure and subsequently precipitated in water to give a yellowish solid product. Finally, the target compound 5-bromo-2-thienylboronic acid methyliminodiacetate was obtained by drying at high temperature.
5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Bromothiophene-2-boronic acid MIDA ester, 2-(5-Bromothiophen-2-yl)-6-methyl-1,3,6,2-dioxazaborocane-4,8-dione manufacturers
- Product
- 5-Bromothiophene-2-boronic acid MIDA este 943552-31-6
- Price
- US $5.90-3.90/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- g-kg-tons, free sample is available
- Release date
- 2025-06-13