Azeliragon
- Product Name
- Azeliragon
- CAS No.
- 603148-36-3
- Chemical Name
- Azeliragon
- Synonyms
- TTP488;CRL 40G;TTP 488;TTP-488;CS-2071;AZELIRAGON;PF04494700;PF 04494700;PF-04494700;Neoprene latex
- CBNumber
- CB52123238
- Molecular Formula
- C32H38ClN3O2
- Formula Weight
- 532.12
- MOL File
- 603148-36-3.mol
Azeliragon Property
- Boiling point:
- 667.7±65.0 °C(Predicted)
- Density
- 1.11±0.1 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO:50.33(Max Conc. mg/mL);94.58(Max Conc. mM)
DMF:5.0(Max Conc. mg/mL);9.4(Max Conc. mM)
DMF:PBS (pH 7.2) (1:2):0.33(Max Conc. mg/mL);0.62(Max Conc. mM)
Ethanol:50.5(Max Conc. mg/mL);94.9(Max Conc. mM) - form
- A crystalline solid
- pka
- 10.16±0.25(Predicted)
- color
- White to light yellow
- InChIKey
- KJNNWYBAOPXVJY-UHFFFAOYSA-N
- SMILES
- C(N(CC)CC)CCOC1=CC=C(C2=CN(C3=CC=C(OC4=CC=C(Cl)C=C4)C=C3)C(CCCC)=N2)C=C1
Safety
- WGK Germany
- WGK 3
- Storage Class
- 11 - Combustible Solids
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 24678
- Product name
- Azeliragon
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 24678
- Product name
- Azeliragon
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 24678
- Product name
- Azeliragon
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $166
- Updated
- 2024/03/01
- Product number
- CS-5117
- Product name
- Azeliragon
- Purity
- 98.79%
- Packaging
- 10mg
- Price
- $228
- Updated
- 2021/12/16
- Product number
- CS-5117
- Product name
- Azeliragon
- Purity
- 98.79%
- Packaging
- 5mg
- Price
- $144
- Updated
- 2021/12/16
Azeliragon Chemical Properties,Usage,Production
Uses
Azeliragon (TTP488) is an orally bioavailable inhibitor of the receptor for advanced glycation end products (RAGE) in development as a potential treatment to slow disease progression in patients with mild Alzheimer’s disease (AD)[1]. Azeliragon also can cross the blood-brain barrier (BBB)[2].
Biological Activity
Azeliragon (TTP488, PF-04494700) is an orally bioavailable small molecule inhibitor that inhibits the receptor for advanced glycation end products (RAGE). RAGE is an immunoglobulin-like cell surface receptor that is overexpressed in the brains of Alzheimer's patients.
in vivo
Azeliragon (100 mcg/d; intraperitoneal injection; every day) treatment reduces syngeneic islet graft and islet allograft in NOD and B6 mice (Islets were isolated from young prediabetic NOD/LtJ mice and transplanted into NOD mice with spontaneous diabetes; islets were isolated from WT BALB/c mice and transplanted into B6 mice with diabetes)[3].
| Animal Model: | Prediabetic NOD/LtJ (6-7 week old) mice, NOD mice with spontaneous diabetes, WT BALB/c mice (8-10 week old) and B6 mice with diabetes [3]. |
| Dosage: | 100 mcg/d |
| Administration: | Intraperitoneal injection; every day |
| Result: | Prolonged islet auto and allograft survival. |
target
| Target | Value |
| RAGE () |