3(2H)-Isoquinolinone, 6-fluoro-
- Product Name
- 3(2H)-Isoquinolinone, 6-fluoro-
- CAS No.
- 51463-15-1
- Chemical Name
- 3(2H)-Isoquinolinone, 6-fluoro-
- Synonyms
- 6-Fluoroisoquinolin-3-ol;6-Fluoroisoquinolin-3(2H)-one;6-fluoro-2H-isoquinolin-3-one;6-Fluoro-3-hydroxyisoquinoline;3(2H)-Isoquinolinone, 6-fluoro-
- CBNumber
- CB52129896
- Molecular Formula
- C9H6FNO
- Formula Weight
- 163.15
- MOL File
- 51463-15-1.mol
3(2H)-Isoquinolinone, 6-fluoro- Property
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F592133
- Product name
- 6-Fluoroisoquinolin-3-ol
- Packaging
- 250mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- PC902157
- Product name
- 6-Fluoroisoquinolin-3-ol
- Purity
- 98%
- Packaging
- 1g
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CHM0386249
- Product name
- 6-FLUOROISOQUINOLIN-3-OL
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $503
- Updated
- 2021/12/16
- Product number
- PC902157
- Product name
- 6-Fluoroisoquinolin-3-ol
- Purity
- 98%
- Packaging
- 5g
- Price
- $595
- Updated
- 2021/12/16
- Product number
- V6327
- Product name
- 6-Fluoroisoquinolin-3-ol
- Packaging
- 10g
- Price
- $791
- Updated
- 2021/12/16
3(2H)-Isoquinolinone, 6-fluoro- Chemical Properties,Usage,Production
Synthesis
1175272-50-0
51463-15-1
Compound B-42 (1.0 g, 6.6 mmol) was mixed with concentrated sulfuric acid (1.4 mL) and the reaction was stirred at 85 °C for 5 min. Upon completion of the reaction, the mixture was cooled to room temperature, slowly poured into ice water (40 mL) and neutralized with saturated aqueous sodium bicarbonate to pH=7-8. Subsequently, the mixture was diluted by addition of dichloromethane (100 mL) and stirred for 12 hr at 20 °C. Upon completion of the reaction, the precipitated product was collected by filtration. The resulting solid was further purified by silica gel column with eluent ratio of dichloromethane: methanol = 10:1, resulting in compound B-43 (0.9 g, 63% yield) as a yellow solid.1H-NMR (CDCl3, 400 MHz) data were as follows: δ 8.67 (s, 1H), 7.90 (q, J=8.0 Hz, 1H), 7.23 (dd, J =4.0 Hz, J=12Hz, 1H), 7.07-7.02 (m, 1H), 6.82 (s, 1H).
References
[1] Patent: WO2017/69980, 2017, A1. Location in patent: Paragraph 00357; 00358
3(2H)-Isoquinolinone, 6-fluoro- Preparation Products And Raw materials
Raw materials
Preparation Products
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