2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- Product Name
- 2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- CAS No.
- 111992-61-1
- Chemical Name
- 2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- Synonyms
- 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione;2-(3-bromo-2,2-dimethylpropyl)isoindoleline-1,3-dione;2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione;1H-isoindole-1,3(2H)-dione, 2-(3-bromo-2,2-dimethylpropyl)-;2-(3-bromo-2, 2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione
- CBNumber
- CB52132537
- Molecular Formula
- C13H14BrNO2
- Formula Weight
- 296.16
- MOL File
- 111992-61-1.mol
2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
Safety
- HazardClass
- IRRITANT
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B997783
- Product name
- 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione
- Packaging
- 250mg
- Price
- $310
- Updated
- 2021/12/16
- Product number
- FB120070
- Product name
- 2-(3-Bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- Packaging
- 250mg
- Price
- $85
- Updated
- 2021/12/16
- Product number
- FB120070
- Product name
- 2-(3-Bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- Packaging
- 500mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- 040990
- Product name
- 2-(3-Bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione
- Packaging
- 500mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- 2124AA
- Product name
- 2-(3-Bromo-2,2-dimethylpropyl)isoindoline-1,3-dione
- Packaging
- 1g
- Price
- $253
- Updated
- 2021/12/16
2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione Chemical Properties,Usage,Production
Synthesis
136918-14-4
40894-00-6
111992-61-1
The general procedure for the synthesis of 2-(3-bromo-2,2-dimethylpropyl)isoindoline-1,3-dione from 3-hydroxy-1H-isoindol-1-one and 3-bromo-2,2-dimethylpropan-1-ol was as follows: first, 2,3-dihydro-1H-isoindoline-1,3-dione (3.1 g, 21.07 mmol, 1.00 equiv.) and 3-bromo-2,2- dimethylpropan-1-ol (3.4 g, 23.2 mmol) was dissolved in an appropriate amount of solvent. A solution of triphenylphosphine (10.9 g, 41.56 mmol, 2.00 eq.) in tetrahydrofuran (THF, 100 mL) was slowly added dropwise at 0 °C and under nitrogen protection, followed by diisopropyl azodicarboxylate (8.3 g, 41.09 mmol, 2.00 eq.). The reaction mixture was stirred at 25 °C for 12 hours. After completion of the reaction, the mixture was concentrated under reduced pressure to remove the solvent. The crude product was purified by silica gel column chromatography using ethyl acetate/petroleum ether (1:50 v/v) as eluent. The final product was 3.2 g of 2-(3-bromo-2,2-dimethylpropyl)-2,3-dihydro-1H-isoindole-1,3-dione in 51% yield as a colorless oil.
References
[1] Angewandte Chemie - International Edition, 2017, vol. 56, # 37, p. 11242 - 11247
[2] Angew. Chem., 2017, vol. 129, # 37, p. 11394 - 11399,6
[3] Patent: WO2012/158764, 2012, A1. Location in patent: Page/Page column 227
[4] Patent: WO2014/22569, 2014, A1. Location in patent: Page/Page column 107
[5] Patent: US8673925, 2014, B1. Location in patent: Page/Page column 251
2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione Preparation Products And Raw materials
Raw materials
Preparation Products
2-(3-bromo-2,2-dimethylpropyl)-1H-isoindole-1,3(2H)-dione Suppliers
- Tel
- 86-027-67849912
- Fax
- 86-027-87531808
- sales@chemwish.com
- Country
- China
- ProdList
- 35896
- Advantage
- 56
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-87782433 18021532344
- Fax
- 025-87782433
- 1345332203@qq.com
- Country
- China
- ProdList
- 4166
- Advantage
- 58
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 025-58859352 15955137747
- Fax
- 02557626880
- sales01@aikonchem.com
- Country
- China
- ProdList
- 16027
- Advantage
- 58
- Tel
- 15026866316
- 180642609@qq.com
- Country
- China
- ProdList
- 4968
- Advantage
- 58
- Tel
- 13331045123
- Fax
- 86-10-80339217
- 2559355526@qq.com
- Country
- China
- ProdList
- 14190
- Advantage
- 58
- Tel
- 025-57027686 17372956142
- Fax
- 025-57027686
- li_lan@syntitan.com
- Country
- China
- ProdList
- 9999
- Advantage
- 58
- Tel
- 021-57171708 18721745940
- Fax
- QQ1139783351
- sales@api-chem.com
- Country
- China
- ProdList
- 1961
- Advantage
- 58