ChemicalBook > CAS DataBase List > 2-CHLORO-5-PHENYLTHIAZOLE

2-CHLORO-5-PHENYLTHIAZOLE

Product Name
2-CHLORO-5-PHENYLTHIAZOLE
CAS No.
62124-43-0
Chemical Name
2-CHLORO-5-PHENYLTHIAZOLE
Synonyms
2-CHLORO-5-PHENYLOXAZOLE;2-CHLORO-5-PHENYLTHIAZOLE;Oxazole, 2-chloro-5-phenyl-;2-CHLORO-5-PHENYL-1,3-OXAZOLE;6-BroMo-2-Methyl-3h-IMidazol[4,5-B]Pyridine
CBNumber
CB5216033
Molecular Formula
C9H6ClNO
Formula Weight
179.6
MOL File
62124-43-0.mol
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2-CHLORO-5-PHENYLTHIAZOLE Property

storage temp. 
Sealed in dry,Store in freezer, under -20°C
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Safety

HS Code 
2934999090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C993958
Product name
2-Chloro-5-phenyloxazole
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
C993958
Product name
2-Chloro-5-phenyloxazole
Packaging
50mg
Price
$65
Updated
2021/12/16
Apolloscientific
Product number
OR927050
Product name
2-Chloro-5-phenyloxazole
Purity
97%
Packaging
100mg
Price
$115
Updated
2021/12/16
AK Scientific
Product number
Z4955
Product name
2-Chloro-5-phenyloxazole
Packaging
100mg
Price
$120
Updated
2021/12/16
Apolloscientific
Product number
OR927050
Product name
2-Chloro-5-phenyloxazole
Purity
97%
Packaging
250mg
Price
$200
Updated
2021/12/16
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2-CHLORO-5-PHENYLTHIAZOLE Chemical Properties,Usage,Production

Uses

2-Chloro-5-phenyloxazole is a useful research chemical.

Synthesis

1006-68-4

62124-43-0

General procedure for the synthesis of 2-chloro-5-phenyloxazole from 5-phenyloxazole: 5-phenyloxazole (1.0 g, 6.89 mmol) and anhydrous THF (10 mL) were added to a round bottom flask. The reaction system was cooled to -78 °C. At -78 °C, 2.5 M n-butyllithium (nBuLi, 3.03 mL, 7.58 mmol) was slowly added dropwise to the reaction solution, which turned dark red. After keeping the reaction at -78 °C for 15 min, hexachloroethane (1.170 mL, 10.33 mmol) was added. Subsequently, the reaction system was slowly warmed to room temperature over a period of 2 h. The reaction solution was then quenched by pouring it into ice water. The aqueous phase was extracted with ethyl acetate (EtOAc, 2 x 30 mL). The organic phases were combined, washed with saturated aqueous sodium chloride (NaCl), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (ISCO system) using 0-100% ethyl acetate/hexane gradient elution to afford the target product 2-chloro-5-phenyloxazole (600 mg, 3.34 mmol, 49% yield) as a colorless liquid. The product was analyzed by mass spectrometry (calculated value: C9H6ClNO m/z 179.1, measured value: 180.1 [M+H]+); 1H NMR (500 MHz, CDCl3) δ 7.60 (d, J=7.15 Hz, 2H), 7.43 (t, J=7.42 Hz, 2H), 7.38-7.33 (m, 1H), 7.29 (s, 1H). 1H); 13C NMR (126 MHz, CDCl3) δ 153.78, 146.16, 129.01, 126.93, 124.03, 123.31.

References

[1] Organic Letters, 2005, vol. 7, # 15, p. 3351 - 3354
[2] Patent: WO2018/64119, 2018, A1. Location in patent: Paragraph 0819
[3] Patent: WO2013/12827, 2013, A1. Location in patent: Paragraph 00208
[4] Journal of Organic Chemistry, 1996, vol. 61, # 16, p. 5192 - 5193

2-CHLORO-5-PHENYLTHIAZOLE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-CHLORO-5-PHENYLTHIAZOLE Suppliers

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62124-43-0, 2-CHLORO-5-PHENYLTHIAZOLERelated Search:

5-PHENYLOXAZOLE 2-CHLORO-4-PHENYLTHIAZOLE SALOR-INT L168653-1EA 2-CHLORO-5-PHENYLTHIAZOLE 2-Chloroxazole 2-CHLORO-5-METHYLOXAZOLE

  • 2-CHLORO-5-PHENYL-1,3-OXAZOLE
  • 2-CHLORO-5-PHENYLOXAZOLE
  • 2-CHLORO-5-PHENYLTHIAZOLE
  • 6-BroMo-2-Methyl-3h-IMidazol[4,5-B]Pyridine
  • Oxazole, 2-chloro-5-phenyl-
  • 62124-43-0