FMOC-12-AMINODODECANOIC ACID
- Product Name
- FMOC-12-AMINODODECANOIC ACID
- CAS No.
- 128917-74-8
- Chemical Name
- FMOC-12-AMINODODECANOIC ACID
- Synonyms
- FMOC-12-ADO-OH;FMOC-NH-(CH2)11-COOH;FMOC-12-AMINOLAURIC ACID;FMOC-12-AMINODODECANOIC ACID;Fmoc-12-Ado-OH >=98.0% (TLC);12-(FMOC-AMINO)DODECANOIC ACID;12-N-FMOC-Aminododecanoic acid;FMOC-12-AMINODODECANOIC ACID USP/EP/BP;Fmoc-12-aminododecanoic acid≥ 95% (HPLC);(9H-Fluoren-9-yl)MethOxy]Carbonyl 12-Ado-OH
- CBNumber
- CB5225453
- Molecular Formula
- C27H35NO4
- Formula Weight
- 437.57
- MOL File
- 128917-74-8.mol
FMOC-12-AMINODODECANOIC ACID Property
- Melting point:
- 102 °C
- Boiling point:
- 628.8±28.0 °C(Predicted)
- Density
- 1.119±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C
- pka
- 4.78±0.10(Predicted)
- form
- powder
- color
- white
- BRN
- 9593537
Safety
- Safety Statements
- 22-24/25
- WGK Germany
- 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- F472460
- Product name
- 12-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)dodecanoicAcid
- Packaging
- 5G
- Price
- $330
- Updated
- 2021/12/16
- Product number
- 277178
- Product name
- Fmoc-12-aminododecanoic acid
- Packaging
- 2g
- Price
- $333
- Updated
- 2021/12/16
- Product number
- AAA0005020
- Product name
- FMOC-12-ADO-OH
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $740
- Updated
- 2021/12/16
- Product number
- 05103
- Product name
- Fmoc-12-aminododecanoicacid,95%(HPLC)
- Purity
- 95%(HPLC)
- Packaging
- 25G
- Price
- $991.2
- Updated
- 2021/12/16
- Product number
- AAA0005020
- Product name
- FMOC-12-ADO-OH
- Purity
- 95.00%
- Packaging
- 5G
- Price
- $1024.78
- Updated
- 2021/12/16
FMOC-12-AMINODODECANOIC ACID Chemical Properties,Usage,Production
Description
Fmoc-12-aminododecanoic acid is an alkane chian with terminal Fmoc-protected amine and carboxylic acid groups. The compound can be used as a PROTAC linker in the synthesis of PROTACs. The Fmoc group can be deprotected under basic condition to obtain the free amine which can be used for further conjugations. The terminal carboxylic acid can react with primary amine groups in the presence of activators (e.g. EDC, or HATU) to form a stable amide bond.
Chemical Properties
White to off-white powder
Uses
12-((((9H-Fluoren-9-yl)methoxy)carbonyl)amino)dodecanoic Acid has been used as a reactant for the preparation of pro-apoptotic peptide functionalized gold nanoparticles as a new anti-cancer strategy of damaging mitochondria.
reaction suitability
reaction type: Fmoc solid-phase peptide synthesis
Synthesis
82911-69-1
693-57-2
128917-74-8
GENERAL STEPS: 9-Fluorenylmethyl-N-succinimidyl carbonate (Fmoc-OSu, 6.55 g, 21.9 mmol) and sodium bicarbonate (NaHCO3, 2.39 g, 28.5 mmol) were added to a mixture of acetone (90 mL) and water (90 mL) of 12-aminodododecanoic acid (4.71 g, 21.9 mmol). The reaction mixture was stirred at room temperature for 20 hours. Upon completion of the reaction, the pH was adjusted to 4-5 with concentrated hydrochloric acid (HCl) to quench the reaction, followed by extraction of the resulting precipitate with ethyl acetate (EtOAc, 3 x 50 mL). The organic phases were combined, dried over anhydrous sodium sulfate (Na2SO4), filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography (eluent: hexane-ethyl acetate, 3:1) to afford FMOC-12-aminododecanoic acid (4.20 g, 43% yield) as a white solid. The structure of the product was confirmed by 1H NMR and 13C NMR [28].
References
[1] Molecules, 2018, vol. 23, # 6,
FMOC-12-AMINODODECANOIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from FMOC-12-AMINODODECANOIC ACID manufacturers
- Product
- FMOC-12-AMINODODECANOIC ACID 128917-74-8
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-15
- Product
- FMOC-12-AMINODODECANOIC ACID 128917-74-8
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100KG
- Release date
- 2018-08-15