1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Product Name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- CAS No.
- 50741-36-1
- Chemical Name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Synonyms
- 6-Cyano-1,2,3,4-tetrahydroquinoline;2,3,4-Tetrahydroquinoline-6-carbonitrile;1,2,3,4-Tetrahydro-6-quinolinecarbonitrile;1,2,3,4-Tetrahydroquinoline-6-carbonitrile;6-Quinolinecarbonitrile, 1,2,3,4-tetrahydro-
- CBNumber
- CB52369548
- Molecular Formula
- C10H10N2
- Formula Weight
- 158.2
- MOL File
- 50741-36-1.mol
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Property
- Melting point:
- 77-79 °C
- Boiling point:
- 322.9±31.0 °C(Predicted)
- Density
- 1.14±0.1 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- pka
- 1.76±0.20(Predicted)
- Appearance
- Light yellow to yellow Solid
Safety
- HS Code
- 2933499090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- T304108
- Product name
- 1,2,3,4-tetrahydroquinoline-6-carbonitrile
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- P000351344
- Product name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Purity
- 97%
- Packaging
- 100mg
- Price
- $73
- Updated
- 2021/12/16
- Product number
- P000351344
- Product name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $117
- Updated
- 2021/12/16
- Product number
- OR928761
- Product name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Purity
- 96%
- Packaging
- 100mg
- Price
- $160
- Updated
- 2021/12/16
- Product number
- 6247BB
- Product name
- 1,2,3,4-Tetrahydroquinoline-6-carbonitrile
- Packaging
- 100mg
- Price
- $170
- Updated
- 2021/12/16
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Chemical Properties,Usage,Production
Synthesis
22190-35-8
557-21-1
50741-36-1
General procedure for the synthesis of 1,2,3,4-tetrahydroquinoline-6-carbonitrile from 6-bromo-1,2,3,4-tetrahydroquinoline and zinc cyanide: To a solution of 6-bromo-1,2,3,4-tetrahydroquinoline (10 g, 47.15 mmol) in N,N-dimethylformamide (80 mL) was added tetrakis(triphenylphosphine)palladium (2.8 g, 2.42 mmol) and zinc cyanide (6.4 g, 54.49 mmol), and the reaction was stirred at 120 °C in an oil bath for 2 hours. After the reaction was completed, the reaction was quenched by adding water (400 mL), and the organic layer was extracted with dichloromethane (3×50 mL), the organic phases were combined and concentrated in vacuum to obtain the crude product. The crude product was purified by silica gel column chromatography with the eluent being a petroleum ether solution of 1%-20% ethyl acetate to afford 1,2,3,4-tetrahydroquinoline-6-carbonitrile as a yellow solid (6 g, 80% yield).LC/MS (ESI, m/z): [M + H]+ 159.1.1.1H-NMR (300 MHz, CDCl3) δ7.20-7.23 (m , 2H), 6.40 (d, J = 8.1 Hz, 1H), 3.36-3.40 (t, J = 5.7 Hz, 2H), 2.72-2.77 (t, J = 6.3 Hz, 2H), 1.90-1.97 (m, 2H).
References
[1] Patent: WO2012/94462, 2012, A2. Location in patent: Page/Page column 60-61
[2] Patent: US2004/220206, 2004, A1. Location in patent: Page 24; 32
1,2,3,4-Tetrahydroquinoline-6-carbonitrile Preparation Products And Raw materials
Raw materials
Preparation Products
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