(22R)-5α-Lanosta-8,24-diene-3β,22-diol
- Product Name
- (22R)-5α-Lanosta-8,24-diene-3β,22-diol
- CAS No.
- 35963-37-2
- Chemical Name
- (22R)-5α-Lanosta-8,24-diene-3β,22-diol
- Synonyms
- Inotodiol;Inonotus obliquus alcohol;(22R)-5α-Lanosta-8,24-diene-3β,22-diol;Lanosta-8,24-diene-3,22-diol, (3β,22R)-;(3beta,5xi,22R)-lanosta-8,24-diene-3,22-diol
- CBNumber
- CB52400667
- Molecular Formula
- C30H50O2
- Formula Weight
- 442.73
- MOL File
- 35963-37-2.mol
(22R)-5α-Lanosta-8,24-diene-3β,22-diol Property
- Melting point:
- 191-193 °C
- Boiling point:
- 534.3±50.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- 4°C, away from moisture and light
- pka
- 14.97±0.20(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- KKWJCGCIAHLFNE-BJKKHWFXNA-N
- SMILES
- C[C@]12CC[C@H](O)C(C)(C)[C@]1([H])CCC1[C@@]3(CC[C@]([H])([C@H](C)[C@H](O)CC=C(C)C)[C@@]3(C)CCC2=1)C |&1:1,4,9,14,17,19,21,28,r|
N-Bromosuccinimide Price
- Product number
- CFN92367
- Product name
- Inotodiol
- Packaging
- 5mg
- Price
- $426
- Updated
- 2021/12/16
(22R)-5α-Lanosta-8,24-diene-3β,22-diol Chemical Properties,Usage,Production
Uses
Inotodiol activates p53 signaling pathway, inhibits MMP-2/9, and exhibits antitumor activity in cancer cell HeLa. Inotodiol inhibits the generation of ROS and exhibits antioxidant and neuroprotective effects. Inotodiol inhibits the activation of MAPK and NF-κB signaling pathway, and exhibits anti-inflammatory activity. Inotodiol inhibits TLR-4 mediated TNF-α production (IC50 in BMMC and BMDM is 0.7 μM and 3.0 μM), inhibits the degranulation in mast cell, exhibits anti-allergic activity. Inotodiol is orally active[1][2][3][4][5].
in vivo
Inotodiol (2-20 mpk, po, once daily for 3-5 days) inhibits allergic reactions in passive systemic anaphylaxis and passive cutaneous anaphylaxis, exhibits antiasthmatic activity in mouse models[5].
| Animal Model: | Mouse passive anaphylaxis models[5] |
| Dosage: | 2-20 mpk |
| Administration: | po, once daily for 3-5 days |
| Result: | Reduced the decrease in body temperature and ear swelling. |
References
[1] Nakata T, et al. Structure determination of inonotsuoxides A and B and in vivo anti-tumor promoting activity of inotodiol from the sclerotia of Inonotus obliquus. Bioorg Med Chem. 2007;15(1):257-264. DOI:10.1016/j.bmc.2006.09.064
[2] Zhang SD, et al., Inotodiol inhibits cells migration and invasion and induces apoptosis via p53-dependent pathway in HeLa cells. Phytomedicine. 2019 Jul;60:152957. DOI:10.1016/j.phymed.2019.152957
[3] Li Y, et al. Inotodiol protects PC12 cells against injury induced by oxygen and glucose deprivation/restoration through inhibiting oxidative stress and apoptosis[J]. Journal of Applied Biomedicine, 2018, 16(2): 126-132.
[4] Lee SH, et al., Antiaging effect of inotodiol on oxidative stress in human dermal fibroblasts. Biomed Pharmacother. 2022 Sep;153:113311. DOI:10.1016/j.biopha.2022.113311
[5] Liu Y, et al., Inotodiol, an antiasthmatic agent with efficacy and safety, preferentially impairs membrane-proximal signaling for mast cell activation. Int Immunopharmacol. 2023 Apr;117:109854. DOI:10.1016/j.intimp.2023.109854
(22R)-5α-Lanosta-8,24-diene-3β,22-diol Preparation Products And Raw materials
Raw materials
Preparation Products
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