ChemicalBook > CAS DataBase List > BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE

Product Name
BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
CAS No.
166953-64-6
Chemical Name
BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
Synonyms
4-Bromo-N<;BUTTPARK 93\50-52;4-BROMO-N-Z-PIPERIDINE;1-Cbz-4-broMopiperidine;N-CBZ-4-BROMO-PIPERIDINE;4-bromo-n-cbz piperidine;4-BROMO-N-Z-PIPERIDINE,96%;4-BroMo-N-Z-piperidine 96%;4-Bromo-N-Z-piperidine;4-Bromopiperidine, N-CBZ protected
CBNumber
CB5240126
Molecular Formula
C13H16BrNO2
Formula Weight
298.18
MOL File
166953-64-6.mol
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BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Property

Boiling point:
144 °C
Density 
1.374 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.5590(lit.)
Flash point:
>230 °F
storage temp. 
Inert atmosphere,Room Temperature
pka
-2.82±0.40(Predicted)
Appearance
Colorless to light yellow Liquid
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Safety

Hazard Codes 
Xi
WGK Germany 
3
Hazard Note 
Irritant
HS Code 
29333999
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
569224
Product name
4-Bromo-N-Z-piperidine
Purity
96%
Packaging
5g
Price
$119.7
Updated
2025/07/31
Sigma-Aldrich
Product number
569224
Product name
4-Bromo-N-Z-piperidine
Purity
96%
Packaging
1g
Price
$72.6
Updated
2023/06/20
TRC
Product number
B130338
Product name
Benzyl4-Bromopiperidine-1-carboxylate
Packaging
10mg
Price
$45
Updated
2021/12/16
TRC
Product number
B130338
Product name
Benzyl4-Bromopiperidine-1-carboxylate
Packaging
50mg
Price
$60
Updated
2021/12/16
Biosynth Carbosynth
Product number
FB50985
Product name
N-Z-4-Bromo-piperidine
Packaging
1g
Price
$70
Updated
2021/12/16
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BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Chemical Properties,Usage,Production

Synthesis

90633-18-4

501-53-1

166953-64-6

To a reaction flask was added 4-bromopiperidine hydrobromide (5.0 g, 20.4 mmol) and dichloromethane (80 mL) followed by saturated sodium bicarbonate solution (160 mL) and benzyl chloroformate (3.7 mL, 24.5 mmol). The reaction mixture was stirred at 23 °C for 22 hours. Upon completion of the reaction, the mixture was transferred to a partition funnel and the product was extracted with dichloromethane. The organic phases were combined, washed with brine, dried over anhydrous sodium sulfate, filtered and concentrated. Purification by silica gel column chromatography (eluent: hexane/ethyl acetate = 8:1) afforded benzyl 4-bromopiperidine-1-carboxylate (3.02 g, 10.1 mmol, 50% yield) as a colorless oil. Mass spectrum (MS): m/e 298.

References

[1] Patent: WO2003/103669, 2003, A1. Location in patent: Page 44-45

BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Preparation Products And Raw materials

Raw materials

Preparation Products

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BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Suppliers

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166953-64-6, BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATERelated Search:

1-Cbz-3-(broMoMethyl)piperidine 3-IodoMethyl-piperidine-1-carboxylic acid benzyl ester BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE Benzyl (3-bromopropyl)carbamate 4-BROMO-N-METHYL PIPERIDINE

  • N-CBZ-4-BROMO-PIPERIDINE
  • 4-Bromo-N-Cbz-piperidine, Benzyl 4-bromopiperidine-1-carboxylate
  • 4-Bromopiperidine-1-carboxylic acid benzyl ester
  • BUTTPARK 93\50-52
  • BENZYL 4-BROMOTETRAHYDRO-1(2H)-PYRIDINECARBOXYLATE
  • 4-Bromopiperidine, N-CBZ protected
  • 4-BROMO-N-Z-PIPERIDINE,96%
  • 4-bromo-n-cbz piperidine
  • Benzyl 4-bromotetrahydro-1(2H)-pyridinecarboxylate, 90+%
  • Benzyl 4-bromopiperidine-1-carboxylate
  • 4-BROMO-N-Z-PIPERIDINE
  • 1-Piperidinecarboxylic acid, 4-broMo-, phenylMethyl ester
  • 1-Cbz-4-broMopiperidine
  • 4-BroMo-N-Z-piperidine 96%
  • benzyl 4-bromo-1-piperidinecarboxylate
  • 4-Bromo-<I>N<
  • 4-Bromo-<i>N</i>-Z-piperidine
  • benzyl 4-bromopiperidine-1-carboxylate - [B83507]
  • 166953-64-6
  • Building Blocks
  • Piperidines
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • C12 to C13
  • Building Blocks
  • C13
  • API intermediates
  • Chemical Synthesis
  • Halogenated Heterocycles
  • Heterocyclic Building Blocks
  • Piperidines