(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL
- Product Name
- (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL
- CAS No.
- 887707-21-3
- Chemical Name
- (6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL
- Synonyms
- 6-chloro-5-methyl-3-Pyridinemethanol;3-Pyridinemethanol, 6-chloro-5-methyl-;(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL;2-Chloro-5-hydroxymethyl-3-methylpyridine
- CBNumber
- CB52449354
- Molecular Formula
- C7H8ClNO
- Formula Weight
- 157.6
- MOL File
- 887707-21-3.mol
(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL Property
- Boiling point:
- 292.7±35.0 °C(Predicted)
- Density
- 1.263±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- 13.34±0.10(Predicted)
Safety
- HS Code
- 2933399990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H320Causes eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- C993360
- Product name
- (6-Chloro-5-methylpyridin-3-yl)methanol
- Packaging
- 500mg
- Price
- $265
- Updated
- 2021/12/16
- Product number
- OR310307
- Product name
- (6-Chloro-5-methylpyridin-3-yl)methanol
- Packaging
- 1g
- Price
- $290
- Updated
- 2021/12/16
- Product number
- FC143563
- Product name
- (6-Chloro-5-methylpyridin-3-yl)methanol
- Packaging
- 100mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- FC143563
- Product name
- (6-Chloro-5-methylpyridin-3-yl)methanol
- Packaging
- 250mg
- Price
- $200
- Updated
- 2021/12/16
- Product number
- FC143563
- Product name
- (6-Chloro-5-methylpyridin-3-yl)methanol
- Packaging
- 500mg
- Price
- $300
- Updated
- 2021/12/16
(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL Chemical Properties,Usage,Production
Synthesis
176433-43-5
887707-21-3
To a solution of 6-chloro-5-methylnicotinaldehyde (3.20 g, 20.7 mmol) in methanol (22 mL) was slowly added sodium borohydride (863 mg, 22.7 mmol) at 0 °C. The reaction mixture was stirred at room temperature for 2 hours. Subsequently, saturated aqueous ammonium chloride solution (20 mL) was added and the mixture continued to be stirred for 0.5 hours. Upon completion of the reaction, the solvent was removed by distillation under reduced pressure and the residue was washed with water (50 mL) and extracted with dichloromethane (50 mL x 3). The organic layers were combined, dried over anhydrous sodium sulfate and concentrated. The resulting residue was purified by silica gel column chromatography (eluent ratio of petroleum ether/ethyl acetate=2/1) to afford the target product (6-chloro-5-methylpyridin-3-yl)methanol (3.2 g, 88% yield) as a light yellow solid.1H NMR (400 MHz, CDCl3) δ 8.09 (s, 1H), 7.56 (s, 1H), 4.65 (s 2H), 2.33 (s, 3H).
References
[1] European Journal of Medicinal Chemistry, 2016, vol. 108, p. 154 - 165
[2] Patent: WO2006/114213, 2006, A1. Location in patent: Page/Page column 30
(6-CHLORO-5-METHYLPYRIDIN-3-YL)METHANOL Preparation Products And Raw materials
Raw materials
Preparation Products
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