ARZOXIFENE

Product Name: ARZOXIFENE
CAS No.: 182133-25-1
Chemical Name: ARZOXIFENE
Synonyms: SERMIII;ARZOXIFENE;2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol;2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol;Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-;3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol
CBNumber: CB52451290
Molecular Formula: C28H29NO4S
Formula Weight: 475.6
MOL File: 182133-25-1.mol

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ARZOXIFENE Property

Melting point:: 174-176°
Boiling point:: 656.4±55.0 °C(Predicted)
Density: 1.234
pka: 9.20±0.40(Predicted)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: A779700
Product name: Arzoxifene
Packaging: 0.5mg
Price: $195
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: API0005130
Product name: ARZOXIFENE
Purity: 95.00%
Packaging: 5MG
Price: $504.41
Updated: 2021/12/16

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ARZOXIFENE Chemical Properties,Usage,Production

Uses

Arzoxifene is a selective estrogen receptor modulator. It is a potent estrogen antagonist in mammary and uterine tissue while acting as an estrogen agonist to maintain bone density and lower serum cholesterol.

Clinical Use

Arzoxifene is a third-generation SERM currently in Phase III clinical trials for the treatm ent of ER-positive recurrent/metastatic breast cancer. Similar to raloxifene, it is an ER antagonist in both breast and uterine tissues and an ER agonist on bone and the cardiovascular system. Arzoxifene is able to both preserve and build bone mineral density, which makes it a viable candidate for the treatment of osteoporosis. Ample evidence from early clinical trials indicates that arzoxifene also can be utilized as a chemopreventive agent against breast cancer.

Side effects

Adverse effects include hot flashes (major) and headache, nausea, vomiting, and constipation (minor).

ARZOXIFENE Preparation Products And Raw materials

Raw materials

Preparation Products

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ARZOXIFENE Suppliers

China 16 India 1 United States 4 Global 21

American Custom Chemicals Corporation

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Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

Waterstone Technology, LLC

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Email: sales@waterstonetech.com
Country: United States
ProdList: 6786
Advantage: 30

United States Biological

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Email: chemicals@usbio.net
Country: United States
ProdList: 6214
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NE Scientific

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Country: United States
ProdList: 5030
Advantage: 55

182133-25-1, ARZOXIFENERelated Search:

2-(4-METHOXY PHENYL)BENZOTHIOPHENE-6-OL 4-(2-(PIPERIDIN-1-YL)ETHOXY)PHENOL 2-(4-Methoxyphenyl)benzothiophene ARZOXIFENE

ARZOXIFENE

2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]benzo[b]thiophene-6-ol

Benzo[b]thiophene-6-ol, 2-(4-Methoxyphenyl)-3-[4-[2-(1-piperidinyl)ethoxy]phenoxy]-

2-(4-methoxyphenyl)-3-[4-(2-piperidin-1-ylethoxy)phenoxy]-1-benzothiophen-6-ol

3-[(4-{[2-(hexahydropyridin-1-yl)ethyl]oxy}phenyl)oxy]-2-(4-methoxyphenyl)benzo[b]thiophen-6-ol

SERMIII

182133-25-1