6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE

Product Name: 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE
CAS No.: 947248-52-4
Chemical Name: 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE
Synonyms: 2-Amino-6-bromoimidazo[1,2-a]pyridine;6-broMoH-iMidazo[1,2-a]pyridin-2-aMine;IMIDAZO[1,2-A]PYRIDIN-2-AMINE, 6-BROMO-;(6-BroMoiMidazo[1,2-a]pyridin-2-yl)aMine
CBNumber: CB52451917
Molecular Formula: C7H6BrN3
Formula Weight: 212.05
MOL File: 947248-52-4.mol

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6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE Property

Density: 1.87±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2–8 °C
pka: 8.45±0.50(Predicted)
Appearance: Light yellow to brown Solid
InChI: InChI=1S/C7H6BrN3/c8-5-1-2-7-10-6(9)4-11(7)3-5/h1-4H,9H2
InChIKey: LAUJNLOJYLUKCP-UHFFFAOYSA-N
SMILES: C12=NC(N)=CN1C=C(Br)C=C2

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Safety

HS Code: 2933599590

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

TRC

Product number: A607820
Product name: 2-Amino-6-bromoimidazo[1,2-a]pyridine
Packaging: 300mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB162605
Product name: 6-Bromoimidazo[1,2-a]pyridin-2-amine
Packaging: 100mg
Price: $400
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0006683
Product name: 6-BROMOIMIDAZO[1,2-A]PYRIDIN-2-AMINE
Purity: 95.00%
Packaging: 100MG
Price: $635.71
Updated: 2021/12/16

Matrix Scientific

Product number: 081468
Product name: 6-Bromoimidazo[1,2-a]pyridin-2-amine hydrochloride
Purity: 97%
Packaging: 1g
Price: $671
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB162605
Product name: 6-Bromoimidazo[1,2-a]pyridin-2-amine
Packaging: 250mg
Price: $700
Updated: 2021/12/16

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6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE Chemical Properties,Usage,Production

Synthesis

504413-35-8

947248-52-4

General procedure for the synthesis of 2-amino-6-bromoimidazo[1,2-a]pyridine from N-(6-bromoimidazo[1,2-a]pyridin-2-yl)-2,2,2-trifluoroacetamide: N-(6-bromoimidazo[1,2-a]pyridin-2-yl)-2,2,2-trifluoroacetamide (5.5 g, 18.2 mmol) and lithium hydroxide (1.2 g. 27.3 mmol) were dissolved in THF/water (50 mL, 7:3) mixed solvent and the reaction was stirred at room temperature for 24 hours. After completion of the reaction, THF was removed by distillation under reduced pressure and the aqueous phase was extracted with dichloromethane (DCM). The organic layers were combined, washed with saturated brine, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 2-amino-6-bromoimidazo[1,2-a]pyridine (2.9 g, 77% yield) as a light brown solid. The product was analyzed by HPLC (X-Terra column), retention time (Rt): 3.07 min (purity: 97.0%).LC/MS (Atlantis column) showed the molecular ion peak [M+H]+ (ESI): 214.1.1.1H-NMR (DMSO-d6, 400 MHz) δ: 8.58-8.59 (1H, s) , 7.11-7.13 (1H, d), 7.05-7.07 (1H, d), 6.98 (1H, s), 5.19 (2H, s).

References

[1] Patent: WO2010/100144, 2010, A1. Location in patent: Page/Page column 105
[2] Patent: US2009/163489, 2009, A1. Location in patent: Page/Page column 33
[3] Patent: WO2009/10530, 2009, A1. Location in patent: Page/Page column 74
[4] Patent: WO2007/95588, 2007, A1. Location in patent: Page/Page column 65
[5] Patent: WO2018/17435, 2018, A1. Location in patent: Paragraph 00119-00120

6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE Suppliers

China 66 India 1 United Kingdom 4 United States 7 Global 78

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Accela ChemBio Inc.

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947248-52-4, 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINERelated Search:

IMIDAZO[1,2-A]PYRIDIN-2-AMINE 6-BROMO-IMIDAZO[1,2-A]PYRIDIN-2-AMINE

IMIDAZO[1,2-A]PYRIDIN-2-AMINE, 6-BROMO-

2-Amino-6-bromoimidazo[1,2-a]pyridine

(6-BroMoiMidazo[1,2-a]pyridin-2-yl)aMine

6-broMoH-iMidazo[1,2-a]pyridin-2-aMine

947248-52-4