5-CHLOROTHIENO[3,2-B]PYRIDINE

Product Name: 5-CHLOROTHIENO[3,2-B]PYRIDINE
CAS No.: 65977-55-1
Chemical Name: 5-CHLOROTHIENO[3,2-B]PYRIDINE
Synonyms: 5-CHLOROTHIENO[3,2-B]PYRIDINE;Thieno[3,2-b]pyridine, 5-chloro-
CBNumber: CB52452853
Molecular Formula: C7H4ClNS
Formula Weight: 169.63
MOL File: 65977-55-1.mol

More

Less

5-CHLOROTHIENO[3,2-B]PYRIDINE Property

storage temp.: 2-8°C(protect from light)
Appearance: White to off-white Solid
InChI: InChI=1S/C7H4ClNS/c8-7-2-1-6-5(9-7)3-4-10-6/h1-4H
InChIKey: DINNLDMXTNAIQE-UHFFFAOYSA-N
SMILES: C12C=CSC1=CC=C(Cl)N=2

More

Less

Safety

HS Code: 2934999090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

TRC

Product number: C611325
Product name: 5-chlorothieno[3,2-b]pyridine
Packaging: 1g
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0050506
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 100mg
Price: $68
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC165736
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 50mg
Price: $80
Updated: 2021/12/16

ChemScene

Product number: CS-0050506
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 250mg
Price: $113
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC165736
Product name: 5-Chlorothieno[3,2-b]pyridine
Packaging: 100mg
Price: $125
Updated: 2021/12/16

More

Less

5-CHLOROTHIENO[3,2-B]PYRIDINE Chemical Properties,Usage,Production

Synthesis

59445-83-9

65977-55-1

The reaction was carried out with 1-(3-thienyl)ethanone oxime (250 mg, 1.77 mmol) in polyphosphoric acid (1.5 mL) at 100 °C with stirring for 30 min. After completion of the reaction, the reaction solution was poured into saturated aqueous sodium carbonate solution and extracted twice with ethyl acetate. The organic phases were combined, washed sequentially with water and saturated saline, and concentrated. The residue was purified by silica gel column chromatography with ethyl acetate:hexane (3:1) as eluent, and the fraction containing the target product was collected and concentrated. The concentrated residue was dissolved in 1,2-dichloroethane (1.5 mL), and a solution of phosphoryl chloride (225 μL, 2.24 mmol) and N,N-dimethylformamide (63 μL, 0.81 mmol) in 1,2-dichloroethane (0.5 mL), which had been pre-cooled to 0 °C, was slowly added. The reaction solution was stirred for 15 min at room temperature and then heated and refluxed for 16 hr. At the end of the reaction, the reaction solution was poured into water (10 mL) containing sodium acetate (550 mg, 4.05 mmol) and the mixture was stirred at 100 °C for 20 min. After cooling, water (25 mL) was added and extracted twice with ethyl acetate. The organic phases were combined, washed sequentially with saturated aqueous sodium bicarbonate and saturated saline, dried over anhydrous sodium sulfate and concentrated to afford 5-chlorothieno[3,2-b]pyridine 115 mg (38% yield) as a light yellow oil, which solidified on standing. The product was characterized by 1H NMR (400 MHz, CDCl3) and ESI-LCMS: 1H NMR δ 8.12 (d, J = 9 Hz, 1H), 7.80 (d, J = 5 Hz, 1H), 7.50 (d, J = 5 Hz, 1H), 7.28 (d, J = 9 Hz, 1H); ESI-LCMS m/z 170 ([M+H]+) .

References

[1] Patent: WO2008/157270, 2008, A1. Location in patent: Page/Page column 90-91

5-CHLOROTHIENO[3,2-B]PYRIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

5-CHLOROTHIENO[3,2-B]PYRIDINE Suppliers

China 51 India 1 United Kingdom 1 United States 6 Global 59

Xi'an Chengyuan Pharmaceutical Technology Co., Ltd

Tel: 17792872120
Email: 3665789492@qq.com
Country: China
ProdList: 476
Advantage: 58

Shanghai Synthfine Chemical Co.,Ltd

Tel: 15921303235
Fax: QQ489466966
Email: sales@synthfine.com
Country: China
ProdList: 1042
Advantage: 58

Shanghai Xiannuo Biotechnology Co., Ltd.

Tel: 021-50718719 13918719472
Fax: 021-50718719
Country: China
ProdList: 979
Advantage: 58

Shanghai Jian Chao Chemical Technology Co., Ltd.

Tel: 150-2103-5486 18017383231
Fax: qq：2817624287
Email: 983544897@qq.com
Country: China
ProdList: 9342
Advantage: 55

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39966
Advantage: 60

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

NovoChemy Ltd.

Tel: 86-(0)21-31261262 373522135
Fax: 86-(0)21-33250524
Email: sales@novochemy.com
Country: China
ProdList: 6498
Advantage: 58

JW & Y Pharmlab Co., Ltd.

Tel: 021-64340559 13651849907;
Fax: 021- 64345308
Email: xinyu_shi@jwypharmlab.com.cn
Country: China
ProdList: 12000
Advantage: 58

Shanghai RenYue Chemical Technology Co., Ltd.

Tel: 021-62219190; 18321139117
Email: 316441092@qq.com
Country: China
ProdList: 2905
Advantage: 55

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

65977-55-1, 5-CHLOROTHIENO[3,2-B]PYRIDINERelated Search:

5-CHLOROTHIENO[3,2-B]PYRIDINE 5,7-DICHLORO-2-METHYLTHIENO[3,2-B]PYRIDINE METHYL 5-CHLORO-2-METHYL-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE METHYL 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLATE 5-CHLORO-7-METHOXYTHIENO[3,2-B]PYRIDINE 5-CHLORO-7-(TRIFLUOROMETHYL)THIENO[3,2-B]PYRIDINE-3-CARBOXYLIC ACID 5,7-DICHLORO-3-METHYLTHIENO[3,2-B]PYRIDINE 5,7-DICHLOROTHIENO[3,2-B]PYRIDINE AKOS 93181

5-CHLOROTHIENO[3,2-B]PYRIDINE

Thieno[3,2-b]pyridine, 5-chloro-

65977-55-1