5-BROMO-3-FORMYL-4-METHYLPYRIDINE
- Product Name
- 5-BROMO-3-FORMYL-4-METHYLPYRIDINE
- CAS No.
- 351457-86-8
- Chemical Name
- 5-BROMO-3-FORMYL-4-METHYLPYRIDINE
- Synonyms
- 5-BroMo-4-Methylnicotinaldehyde;5-BROMO-3-FORMYL-4-METHYLPYRIDINE;5-Bromo-4-methyl-pyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 5-bromo-4-methyl-
- CBNumber
- CB52452873
- Molecular Formula
- C7H6BrNO
- Formula Weight
- 200.03
- MOL File
- 351457-86-8.mol
5-BROMO-3-FORMYL-4-METHYLPYRIDINE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H303May be harmfulif swallowed
H320Causes eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- B613615
- Product name
- 5-Bromo-4-methylnicotinaldehyde
- Packaging
- 2.5g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- Z0536
- Product name
- 5-Bromo-3-formyl-4-methylpyridine
- Packaging
- 100mg
- Price
- $109
- Updated
- 2021/12/16
- Product number
- HCH0359374
- Product name
- 5-BROMO-4-METHYLNICOTINALDEHYDE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $292.95
- Updated
- 2021/12/16
- Product number
- 153235
- Product name
- 5-Bromo-4-methylnicotinaldehyde
- Purity
- 95%
- Packaging
- 250mg
- Price
- $315
- Updated
- 2021/12/16
- Product number
- 35272
- Product name
- 5-Bromo-4-methylnicotinaldehyde
- Purity
- 95+%
- Packaging
- 1g
- Price
- $680
- Updated
- 2021/12/16
5-BROMO-3-FORMYL-4-METHYLPYRIDINE Chemical Properties,Usage,Production
Synthesis
3430-23-7
68-12-2
351457-86-8
(a) Synthesis of Intermediate 1a (5-bromo-3-formyl-4-methylpyridine): 3,5-dibromo-4-methylpyridine (3.8 g, 15.1 mmol) was dissolved in anhydrous tetrahydrofuran (150 mL) under argon protection and cooled to -100 °C (using a liquid nitrogen/ether bath). Slowly n-butyllithium (2.5 M hexane solution, 6.2 mL, 15.4 mmol) was added dropwise and the reaction mixture was stirred at -100 °C for 5 min. Subsequently, N,N-dimethylformamide (1.8 mL, 23.2 mmol) was added and stirring was continued at -100 °C for 20 min. The reaction mixture was then warmed to -78 °C and kept for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated aqueous sodium bicarbonate and aqueous ammonium chloride and extracted with ether. The organic phases were combined, washed with saturated saline, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography (eluent: 20% ethyl acetate/hexane) afforded Intermediate 1a (2.18 g, 72% yield) as a clear oil, which solidified slowly. The product was characterized by 1H NMR (300 MHz, CDCl3): δ 10.25 (s, 1H), 8.84 (s, 1H), 8.83 (s, 1H), 2.76 (s, 3H). Elemental analysis (C7H6BrNO) is consistent with theoretical values.
References
[1] Patent: WO2006/54151, 2006, A1. Location in patent: Page/Page column 8
[2] Bioorganic and Medicinal Chemistry Letters, 2007, vol. 17, # 15, p. 4297 - 4302
5-BROMO-3-FORMYL-4-METHYLPYRIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
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