ChemicalBook > CAS DataBase List > (R)-SLV 319

(R)-SLV 319

Product Name
(R)-SLV 319
CAS No.
656827-86-0
Chemical Name
(R)-SLV 319
Synonyms
(R)-SLV 319;SLV 319, (R)-(+)-;(4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide;4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide;1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)-
CBNumber
CB52453032
Molecular Formula
C23H20Cl2N4O2S
Formula Weight
487.4
MOL File
656827-86-0.mol
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(R)-SLV 319 Property

Boiling point:
623.2±65.0 °C(Predicted)
Density 
1.38±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
≤30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide
form 
crystalline solid
pka
11?+-.0.60(Predicted)
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
10009227
Product name
(R)-SLV 319
Purity
≥98%
Packaging
1mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
10009227
Product name
(R)-SLV 319
Purity
≥98%
Packaging
5mg
Price
$317
Updated
2024/03/01
Cayman Chemical
Product number
10009227
Product name
(R)-SLV 319
Purity
≥98%
Packaging
10mg
Price
$475
Updated
2024/03/01
Cayman Chemical
Product number
10009227
Product name
(R)-SLV 319
Purity
≥98%
Packaging
50mg
Price
$1344
Updated
2021/12/16
ApexBio Technology
Product number
C5122
Product name
(R)-SLV319
Packaging
50mg
Price
$1863
Updated
2021/12/16
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(R)-SLV 319 Chemical Properties,Usage,Production

Description

Central cannabinoid (CB1) receptor antagonists may have potential in the treatment of a number of diseases such as neuroinflammatory disorders, cognitive disorders, septic shock, obesity, psychosis, addiction, and gastrointestinal disorders. (R)-SLV 319 is the inactive enantiomer of SLV 319 with 100-fold less affinity for the CB1 receptor. SLV 319 is a potent and selective CB1 receptor antagonist with Ki values of 7.8 and 7,943 nM for CB1 and peripheral cannabinoid (CB2) receptors, respectively. SLV 319 is less lipophilic (log P = 5.1) and therefore more water soluble than other known CB1 receptor ligands.

in vitro

(r)-slv 319 is the inactive enantiomer of slv 319 with 100-fold less affinity for the cb1 receptor. slv 319 was identified as a potent and selective cb1 receptor antagonist with ki values of 7.8 and 7,943 nm for cb1 and peripheral cannabinoid (cb2) receptors, respectively. slv 319 was found to be less lipophilic and thus more water soluble than other known cb1 receptor ligands [1,2].

in vivo

a previous animal study examined the chronic effects of slv 319 in hyperinsulinemic zucker rats to determine their chronic effects on insulinemia. results showed that r slv 319 at 10 mg·kg-1·day-1 elicited body weight-independent improvements in insulinemia and glycemia during 10 wk of chronic treatment. moreover, slv 319 treatment caused glucose intolerance in cb1 but not sur1-ko mice [3].

References

[1] lange, j. h.m.,coolen, h.k.a.c.,van stuivenberg, h.h., et al. synthesis, biological properties, and molecular modeling investigations of novel 3,4-diarylpyrazolines as potent and selective cb1 cannabinoid receptor antagonists. journal of medicinal chemistry 47(3), 627-643 (2004).
[2] lange, j. h.m.,van stuivenberg, h.h.,veerman, w., et al. novel 3,4-diarylpyrazolines as potent cannabinoid cb1 receptor antagonists with lower lipophilicity. bioorganic & medicinal chemistry letters 15, 4794-4798 (2005).
[3] lynch cj, zhou q, shyng sl, heal dj, cheetham sc, dickinson k, gregory p, firnges m, nordheim u, goshorn s, reiche d, turski l, antel j. some cannabinoid receptor ligands and their distomers are direct-acting openers of sur1 k(atp) channels. am j physiol endocrinol metab. 2012 mar 1;302(5):e540-51.

(R)-SLV 319 Preparation Products And Raw materials

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656827-86-0, (R)-SLV 319Related Search:

(R)-SLV 319 3-(4-CHLOROPHENYL)-4-PHENYL-1H PYRAZOLE

  • (R)-SLV 319
  • (4R)-5-(4-chlorophenyl)-N-(4-chlorophenyl)sulfonyl-N'-methyl-4-phenyl-3,4-dihydropyrazole-2-carboximidamide
  • 4-chloro-N-{[3-(4-chloro-phenyl)-4-phenyl-4,5-dihydro-pyrazol-1-yl]-methylamino-methylene}-benzenesulfonamide
  • 1H-Pyrazole-1-carboximidamide, 3-(4-chlorophenyl)-N-[(4-chlorophenyl)sulfonyl]-4,5-dihydro-N'-methyl-4-phenyl-, (4R)-
  • SLV 319, (R)-(+)-
  • 656827-86-0