TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE
- Product Name
- TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE
- CAS No.
- 166104-19-4
- Chemical Name
- TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE
- Synonyms
- 1-BOC-5-nitro indole;1-Boc-5-nitro-1H-indole;1-Boc-5-nitro-1H-indole;tert-Butyl 5-nitroindole-1-carboxylate;TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE;5-nitro-1-indolecarboxylic acid tert-butyl ester;5-Nitro-indole-1-carboxylic acid tert-butyl ester;1H-Indole-1-carboxylic acid, 5-nitro-, 1,1-diMethylethyl ester
- CBNumber
- CB52453173
- Molecular Formula
- C13H14N2O4
- Formula Weight
- 262.26
- MOL File
- 166104-19-4.mol
TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE Property
- Melting point:
- 115℃
- storage temp.
- 2-8°C
- form
- solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- VBP00189
- Product name
- 1-Boc-5-nitro-1H-indole
- Packaging
- 1g
- Price
- $259
- Updated
- 2025/07/31
- Product number
- FB140481
- Product name
- tert-Butyl 5-nitro-1H-indole-1-carboxylate
- Packaging
- 5G
- Price
- $348
- Updated
- 2021/12/16
- Product number
- W3612
- Product name
- tert-butyl5-nitro-1H-indole-1-carboxylate
- Packaging
- 5g
- Price
- $451
- Updated
- 2021/12/16
- Product number
- FB140481
- Product name
- tert-Butyl 5-nitro-1H-indole-1-carboxylate
- Packaging
- 500mg
- Price
- $55
- Updated
- 2021/12/16
- Product number
- FB140481
- Product name
- tert-Butyl 5-nitro-1H-indole-1-carboxylate
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE Chemical Properties,Usage,Production
Synthesis
24424-99-5
6146-52-7
166104-19-4
Di-tert-butyl dicarbonate (524 mg, 2.4 mmol) and 5-nitro-1H-indole (325 mg, 2.0 mmol) were used as raw materials and stirred in dichloromethane (6 mL) for 5 min at 0 °C. Subsequently, a catalytic amount of 4-dimethylaminopyridine (3 mg, 0.025 mmol) was added and stirring was continued for 30 min at room temperature. Upon completion of the reaction, the reaction was quenched by the addition of water (2 mL) and extracted with dichloromethane (15 mL x 3). The organic phases were combined, washed sequentially with water (20 mL) and saturated brine (15 mL × 2) and dried over anhydrous sodium sulfate. The solvent was removed by distillation under reduced pressure to afford the gray solid product tert-butyl 5-nitro-1H-indole-1-carboxylate (526 mg, 100% yield), which could be used in the next reaction without further purification.
References
[1] Journal of Medicinal Chemistry, 2013, vol. 56, # 15, p. 6273 - 6277
[2] Patent: CN104311541, 2017, B. Location in patent: Paragraph 0162; 0163
[3] Synthesis, 2009, # 21, p. 3617 - 3632
[4] Patent: WO2016/176460, 2016, A1. Location in patent: Page/Page column 96
[5] Patent: US2009/247568, 2009, A1. Location in patent: Page/Page column 35-36
TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE Preparation Products And Raw materials
Raw materials
Preparation Products
TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE Suppliers
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View Lastest Price from TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE manufacturers
- Product
- TERT-BUTYL 5-NITRO-1H-INDOLE-1-CARBOXYLATE 166104-19-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 100KG
- Release date
- 2020-01-12