1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE

Product Name: 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE
CAS No.: 791846-40-7
Chemical Name: 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE
Synonyms: tert-Butyl 4-(4-bromo-2-cyanophenyl);1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE;TERT-BUTYL 4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE-1-CARBOXYLATE;4-(4-Bromo-2-cyano-phenyl)-piperazine-1-carboxylic acid tert-butyl ester;1-Piperazinecarboxylic acid, 4-(4-bromo-2-cyanophenyl)-, 1,1-dimethylethyl ester
CBNumber: CB52453764
Molecular Formula: C16H20BrN3O2
Formula Weight: 366.25
MOL File: 791846-40-7.mol

More

Less

1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Property

storage temp.: Sealed in dry,Room Temperature

More

Less

Hazard and Precautionary Statements (GHS)

More

Less

N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FB144043
Product name: tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate
Packaging: 250mg
Price: $62.5
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144043
Product name: tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate
Packaging: 500mg
Price: $110
Updated: 2021/12/16

AK Scientific

Product number: W8485
Product name: 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine
Packaging: 250mg
Price: $111
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FB144043
Product name: tert-Butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate
Packaging: 1g
Price: $189
Updated: 2021/12/16

Matrix Scientific

Product number: 072475
Product name: 1-Boc-4-(4-Bromo-2-cyanophenyl)piperazine
Purity: 95+%
Packaging: 250mg
Price: $231
Updated: 2021/12/16

More

Less

1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Chemical Properties,Usage,Production

Synthesis

179897-89-3

57260-71-6

791846-40-7

General procedure for the synthesis of 1-BOC-4-(4-bromo-2-cyanophenyl)piperazine from 2-fluoro-5-bromobenzonitrile and N-BOC-piperazine: in a pressure tube, 5-bromo-2-fluorobenzonitrile (2,500 mg, 12.5 mmol), tert-butyl piperazine-1-carboxylate (2,444.45 mg, 13.12 mmol) and triethylamine (5.23 mL. 37.5 mmol) were dissolved in dimethyl sulfoxide (10 mL) and the reaction was refluxed at 100 °C. After completion of the reaction, the mixture was cooled and separated by extraction with ethyl acetate and saturated aqueous sodium bicarbonate. The organic phase was dried with anhydrous sodium sulfate and concentrated under reduced pressure. The crude product was purified by fast column chromatography on silica gel, eluting with a 5-60% ethyl acetate/hexane gradient to afford the light brown oily product tert-butyl 4-(4-bromo-2-cyanophenyl)piperazine-1-carboxylate (3660 mg, 80% yield).

References

[1] Patent: KR2016/37198, 2016, A. Location in patent: Paragraph 2392-2394
[2] Bioorganic and Medicinal Chemistry Letters, 2004, vol. 14, # 20, p. 5095 - 5098
[3] Patent: WO2017/38909, 2017, A1. Location in patent: Paragraph 0290; 0291
[4] Patent: WO2009/79593, 2009, A1. Location in patent: Page/Page column 120

1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE Suppliers

China 29 India 1 United Kingdom 1 United States 6 Global 37

Pure Chemistry Scientific Inc.

Tel: 001-857-928-2050 or 1-888-588-9418
Fax: 001-617-206-9595
Email: sales@chemreagents.com
Country: United States
ProdList: 10186
Advantage: 62

Shanghai Hanhong Scientific Co.,Ltd.

Tel: 021-54306202 13764082696
Email: info@hanhongsci.com
Country: China
ProdList: 42934
Advantage: 64

SynAsst Chemical.

Tel: 021-60343070
Fax: 021-35122006
Country: China
ProdList: 12740
Advantage: 55

ShangHai KenEn Chemical Technology Co., Ltd.

Tel: 13120367189
Fax: 021-50315529
Email: mychess007@163.com
Country: China
ProdList: 1994
Advantage: 55

ShangHai AmK Pharmaceutical Technology Co., Ltd.

Tel: 微信 17321281695 18019252918
Fax: 17321281695
Email: sale@amkchem.com
Country: China
ProdList: 15136
Advantage: 55

Cool Pharm, Ltd

Tel: 021-60455363 18019463053
Fax: 50966098
Email: sales@coolpharm.com
Country: China
ProdList: 12346
Advantage: 58

Amadis Chemical Company Limited

Tel: 571-89925085
Fax: 0086-571-89925065
Email: sales@amadischem.com
Country: China
ProdList: 131957
Advantage: 58

Hangzhou Molcore Biopharmatech Co.,Ltd

Tel: 400-711-5280 86-571-81025280
Fax: 86-571-85806285
Email: sales@molcore.com
Country: China
ProdList: 9967
Advantage: 58

Aikon International Limited

Tel: 025-58851090 15955137747
Fax: (6)02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15949
Advantage: 58

Suzhou Nuoouman Biological Technology Co., Ltd.

Tel: 15026866316
Email: 180642609@qq.com
Country: China
ProdList: 4967
Advantage: 58

791846-40-7, 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINERelated Search:

2-(4-METHYLPIPERAZIN-1-YL)BENZONITRILE 1-(4-BROMO-2-CYANOPHENYL)PIPERAZINE 2-AMINO-5-BROMOBENZONITRILE TERT-BUTYL 4-(2-CYANOPHENYL)PIPERAZINE-1-CARBOXYLATE 1-(2-CYANOPHENYL)PIPERAZINE 4-(4-BROMO-PHENYL)-PIPERAZINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER 1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE

1-BOC-4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE

TERT-BUTYL 4-(4-BROMO-2-CYANOPHENYL)PIPERAZINE-1-CARBOXYLATE

tert-Butyl 4-(4-bromo-2-cyanophenyl)

4-(4-Bromo-2-cyano-phenyl)-piperazine-1-carboxylic acid tert-butyl ester

1-Piperazinecarboxylic acid, 4-(4-bromo-2-cyanophenyl)-, 1,1-dimethylethyl ester

791846-40-7