6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE
- Product Name
- 6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE
- CAS No.
- 207306-50-1
- Chemical Name
- 6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE
- Synonyms
- TB 21007;6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE;Benzo[c]thiophen-4(5H)-one, 6,7-dihydro-3-[(2-hydroxyethyl)thio]-6,6-dimethyl-1-(2-thiazolyl)-;3-(2-hydroxyethylsulfanyl)-6,6-dimethyl-1-(1,3-thiazol-2-yl)-5,7-dihydro-2-benzothiophen-4-one
- CBNumber
- CB52454332
- Molecular Formula
- C15H17NO2S3
- Formula Weight
- 339.5
- MOL File
- 207306-50-1.mol
6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE Property
- Melting point:
- 175-177 °C
- Boiling point:
- 544.9±60.0 °C(Predicted)
- Density
- 1.39±0.1 g/cm3(Predicted)
- storage temp.
- Store at +4°C
- solubility
- DMSO: 100 mM; Ethanol: 25 mM
- form
- A solid
- pka
- 14.22±0.10(Predicted)
- color
- white to beige
N-Bromosuccinimide Price
- Product number
- SML3300
- Product name
- TB21007
- Purity
- ≥98% (HPLC)
- Packaging
- 5MG
- Price
- $78.52
- Updated
- 2025/07/31
- Product number
- SML3300
- Product name
- TB21007
- Purity
- ≥98% (HPLC)
- Packaging
- 25MG
- Price
- $386
- Updated
- 2025/07/31
- Product number
- 27674
- Product name
- TB 21007
- Packaging
- 5mg
- Price
- $110
- Updated
- 2024/03/01
- Product number
- 27674
- Product name
- TB 21007
- Packaging
- 25mg
- Price
- $459
- Updated
- 2024/03/01
- Product number
- 27674
- Product name
- TB 21007
- Packaging
- 10mg
- Price
- $195
- Updated
- 2024/03/01
6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE Chemical Properties,Usage,Production
Description
TB 21007 is an inverse agonist of α5β3γ2 subunit-containing GABAA receptors (Ki = 1.6 nM). It selectively inhibits α5β3γ2 subunit-containing GABAA receptors over α1-4 and α6 subunit-containing GABAA receptors that also contain β3 and γ2 subunits (Kis = 20, 16, 20, 106, and 1,800 nM, respectively). TB 21007 reduces the latency to find the hidden platform in a matching-to-place variant of the Morris water maze, indicating enhanced spatial memory, in rats when administered at a dose of 0.3 mg/kg. It reduces paw tactile allodynia induced by reserpine in a rat model of fibromyalgia-like pain when administered intrathecally at doses of 1.5, 15, and 150 nmol.
Uses
TB 21007 is a selective GABAA α5 receptor inverse agonist which enhances cognition.
Biological Activity
GABA A receptor inverse agonist selective for the α 5 -subtype (K i values are 1.6, 16, 20 and 20 nM for α 5, α 2, α 1 and α 3 subtypes respectively). Brain penetrant; enhances cognitive performance in rats in the delayed matching-to-place morris water maze test following i.p. administration.
storage
Store at +4°C
References
[1] MARK S. CHAMBERS. Identification of a Novel, Selective GABAA α5 Receptor Inverse Agonist Which Enhances Cognition[J]. Journal of Medicinal Chemistry, 2003, 46 11: 2227-2240. DOI: 10.1021/jm020582q
[2] L. BUCHWALDT H G. Phytotoxicity of destruxin B and its possible role in the pathogenesis of Alternaria brassicae[J]. Plant Pathology, 1992, 41 1: 55-63. DOI: 10.1111/j.1365-3059.1992.tb02316.x
6,7-DIHYDRO-3-[(2-HYDROXYETHYL)THIO]-6,6-DIMETHYL-1-(2-THIAZOLYL)-BENZO[C]THIOPHEN-4(5H)-ONE Preparation Products And Raw materials
Raw materials
Preparation Products
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