6-(BENZYLOXY)NICOTINALDEHYDE
- Product Name
- 6-(BENZYLOXY)NICOTINALDEHYDE
- CAS No.
- 635712-99-1
- Chemical Name
- 6-(BENZYLOXY)NICOTINALDEHYDE
- Synonyms
- 6-(BENZYLOXY)NICOTINALDEHYDE;6-Benzyloxypyridine-3-carboxaldehyde;6-Phenylmethoxypyridine-3-carbaldehyde;3-Pyridinecarboxaldehyde, 6-(phenylmethoxy)-
- CBNumber
- CB52454488
- Molecular Formula
- C13H11NO2
- Formula Weight
- 213.23
- MOL File
- 635712-99-1.mol
6-(BENZYLOXY)NICOTINALDEHYDE Property
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
N-Bromosuccinimide Price
- Product number
- B288083
- Product name
- 6-(Benzyloxy)nicotinaldehyde
- Packaging
- 500mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- FB142625
- Product name
- 6-(Benzyloxy)nicotinaldehyde
- Packaging
- 500mg
- Price
- $50
- Updated
- 2021/12/16
- Product number
- FB142625
- Product name
- 6-(Benzyloxy)nicotinaldehyde
- Packaging
- 1g
- Price
- $89
- Updated
- 2021/12/16
- Product number
- 9701AB
- Product name
- 6-(Benzyloxy)nicotinaldehyde
- Packaging
- 1g
- Price
- $138
- Updated
- 2021/12/16
- Product number
- FB142625
- Product name
- 6-(Benzyloxy)nicotinaldehyde
- Packaging
- 2g
- Price
- $154
- Updated
- 2021/12/16
6-(BENZYLOXY)NICOTINALDEHYDE Chemical Properties,Usage,Production
Synthesis
83664-33-9
68-12-2
635712-99-1
General procedure for the synthesis of 6-(benzyloxy)nicotinaldehyde from 2-benzyloxy-5-bromopyridine and N,N-dimethylformamide: n-butyllithium (2.5 M hexane solution, 2.61 mL, 1.05 eq.) was slowly added to a tetrahydrofuran solution (25 mL, -78 °C) of 2-benzyloxy-5-bromopyridine (1.64 g, 6.2 mmol). After 1 hour of reaction at -78 °C, N,N-dimethylformamide (0.97 mL, 2 eq.) was added and stirring was continued at -78 °C for 30 minutes. The reaction mixture was rapidly poured into a stirring 5% aqueous sodium bicarbonate solution (50 mL) and extracted with ether (3 x 50 mL). The organic phases were combined, washed with saturated brine, dried over anhydrous magnesium sulfate, filtered and concentrated to give a crude product of 1.16 g (quantitative yield), which could be used in the next reaction without further purification. Mass spectrometry analysis showed a molecular ion peak of 186.34 ([MH]+) for the target compound.
References
[1] Patent: WO2003/104236, 2003, A1. Location in patent: Page 169
[2] Polyhedron, 2013, vol. 52, p. 755 - 760
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 6, p. 2536 - 2548
[4] Patent: WO2004/92145, 2004, A1. Location in patent: Page 149
[5] Patent: US2009/82403, 2009, A1. Location in patent: Page/Page column 66
6-(BENZYLOXY)NICOTINALDEHYDE Preparation Products And Raw materials
Raw materials
Preparation Products
6-(BENZYLOXY)NICOTINALDEHYDE Suppliers
- Tel
- 021-50182298 021-50180596
- Fax
- +86-21-57758967
- sales@boylechem.com
- Country
- China
- ProdList
- 2208
- Advantage
- 55
- Tel
- 13526569071
- sales@leadmedpharm.com
- Country
- China
- ProdList
- 7892
- Advantage
- 64
- Tel
- 0319-5801333-8008 15630992918
- sales@summedchem.com
- Country
- China
- ProdList
- 965
- Advantage
- 58
- Tel
- 86(21)68097365
- Fax
- 86(21)33321566
- sales@anpharma.net
- Country
- China
- ProdList
- 4891
- Advantage
- 55
- Tel
- 0519-85528066 13775048983
- Fax
- 0519-85528066
- sales@hopschem.com
- Country
- China
- ProdList
- 31553
- Advantage
- 55
- Tel
- 400-685-9117
- Fax
- 021-51816740
- market@bepharm.com
- Country
- China
- ProdList
- 15081
- Advantage
- 60
- Tel
- 571-89925085
- Fax
- 0086-571-89925065
- sales@amadischem.com
- Country
- China
- ProdList
- 131957
- Advantage
- 58
- Tel
- 025-66096098 3165145969
- Fax
- QQ3165145969
- sales@accoronpharm.com
- Country
- China
- ProdList
- 3924
- Advantage
- 55
- Tel
- 400-711-5280 86-571-81025280
- Fax
- 86-571-85806285
- sales@molcore.com
- Country
- China
- ProdList
- 9967
- Advantage
- 58
- Tel
- 028-65791793 18140026355
- Fax
- QQ568470422
- 568470422@qq.com
- Country
- China
- ProdList
- 9997
- Advantage
- 58