(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE

Product Name: (S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE
CAS No.: 876379-22-5
Chemical Name: (S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE
Synonyms: -1-Cbz-3-Boc-Aminopiperidine;(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE;Benzyl (3S)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate;benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate;1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester, (3S)-;(3S)-3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-piperidinecarboxylic acid (phenylmethyl) ester
CBNumber: CB52457782
Molecular Formula: C18H26N2O4
Formula Weight: 334.41
MOL File: 876379-22-5.mol

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(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE Property

Boiling point:: 471.9±44.0 °C(Predicted)
Density: 1.15±0.1 g/cm3(Predicted)
storage temp.: 2-8°C
pka: 12.25±0.20(Predicted)

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-37
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: B233205
Product name: Benzyl(S)-3-{[(tert-butoxy)carbonyl]amino}piperidine-1-carboxylate
Packaging: 50mg
Price: $105
Updated: 2021/12/16

TRC

Product number: B233205
Product name: Benzyl(S)-3-{[(tert-butoxy)carbonyl]amino}piperidine-1-carboxylate
Packaging: 100mg
Price: $165
Updated: 2021/12/16

Frontier Specialty Chemicals

Product number: JK997574
Product name: (S)-1-Cbz-3-N-Boc-aminopiperidine
Purity: 95%
Packaging: 250mg
Price: $245
Updated: 2021/12/16

AK Scientific

Product number: W8999
Product name: (S)-1-Cbz-3-Boc-Aminopiperidine
Packaging: 250mg
Price: $259
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: CCH0001357
Product name: (S)-3-TERT-BUTOXYCARBONYLAMINO-PIPERIDINE-1-CARBOXYLIC ACID BENZYL ESTER
Purity: 95.00%
Packaging: 250MG
Price: $351.75
Updated: 2021/12/16

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(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE Chemical Properties,Usage,Production

Synthesis

501-53-1

216854-23-8

876379-22-5

To a 200 mL round bottom flask was added (S)-3-Boc-aminopiperidine (2.02 g, 10.09 mmol) followed by dichloromethane (40 mL) as solvent. Triethylamine (2.25 mL, 16.1 mmol) was added dropwise to the system under stirring. The resulting colorless solution was cooled to 0 °C and then benzyl chloroformate (1.70 mL, 11.9 mmol) was added slowly and dropwise. The reaction mixture was stirred at 0 °C and gradually warmed to room temperature. After completion of the reaction (monitored by TLC), the mixture was extracted by partitioning with dichloromethane and water. The aqueous phase was further extracted with dichloromethane and the combined organic phases were washed with saturated brine and dried over anhydrous sodium sulfate. After filtration, the organic phase was concentrated under reduced pressure to afford (S)-1-Cbz-3-N-Boc-aminopiperidine as a colorless viscous oil, which was crystallized after standing under vacuum (3.35 g, 99% yield).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2012, vol. 22, # 4, p. 1690 - 1694
[2] Patent: EP2842939, 2015, A1. Location in patent: Paragraph 1593
[3] Patent: EP2842946, 2015, A1. Location in patent: Paragraph 1681
[4] Patent: WO2012/58645, 2012, A1. Location in patent: Page/Page column 103-104

(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE Suppliers

China 21 India 2 United Kingdom 1 United States 5 Global 29

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876379-22-5, (S)-1-CBZ-3-N-BOC-AMINOPIPERIDINERelated Search:

(S)-1-CBZ-3-N-BOC-AMINOPIPERIDINE

Benzyl (3S)-3-[(tert-butoxycarbonyl)amino]piperidine-1-carboxylate

-1-Cbz-3-Boc-Aminopiperidine

(3S)-3-[[(2-methylpropan-2-yl)oxy-oxomethyl]amino]-1-piperidinecarboxylic acid (phenylmethyl) ester

1-Piperidinecarboxylic acid, 3-[[(1,1-dimethylethoxy)carbonyl]amino]-, phenylmethyl ester, (3S)-

benzyl (3S)-3-[(2-methylpropan-2-yl)oxycarbonylamino]piperidine-1-carboxylate

876379-22-5