7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE
- Product Name
- 7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE
- CAS No.
- 62484-12-2
- Chemical Name
- 7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE
- Synonyms
- 7-Methoxyquinazoline-2,4-diol;7-Methoxy-1H-quinazoline-2,4-dione;7-Methoxy-2,4(1H,3H)-quinazolinedione;7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE;2,4(1H,3H)-Quinazolinedione, 7-Methoxy-;7-Methoxy-1,2,3,4-tetrahydroquinazoline-2,4-dione
- CBNumber
- CB52459054
- Molecular Formula
- C9H8N2O3
- Formula Weight
- 192.17
- MOL File
- 62484-12-2.mol
7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE Property
- Melting point:
- 299-301℃
- Density
- 1.322
- storage temp.
- Sealed in dry,Room Temperature
- Appearance
- Off-white to light brown Solid
Safety
- HS Code
- 2933998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- Q990053
- Product name
- 7-Methoxy-2,4(1H,3H)-quinazolinedione
- Packaging
- 500mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- OR927579
- Product name
- 7-Methoxyquinazoline-2,4-diol
- Purity
- 95%
- Packaging
- 1g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- OR927579
- Product name
- 7-Methoxyquinazoline-2,4-diol
- Purity
- 95%
- Packaging
- 5g
- Price
- $595
- Updated
- 2021/12/16
- Product number
- 126476
- Product name
- 7-Methoxyquinazoline-2,4-diol
- Purity
- >95%
- Packaging
- 1g
- Price
- $864
- Updated
- 2021/12/16
- Product number
- 126476
- Product name
- 7-Methoxyquinazoline-2,4-diol
- Purity
- >95%
- Packaging
- 5g
- Price
- $2430
- Updated
- 2021/12/16
7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE Chemical Properties,Usage,Production
Synthesis
57-13-6
4294-95-5
62484-12-2
The general procedure for the synthesis of 7-methoxy-2,4(1H,3H)-quinazolinediones from urea and 2-amino-4-methoxybenzoic acid was as follows: 2-amino-4-methoxybenzoic acid (1 g, 5.98 mmol) was mixed with urea (7.18 g, 120 mmol), and the reaction was stirred for 16 hours at 155 °C. After the reaction was completed, the mixture was cooled to 100 °C and 3 mL of water was added. Continued cooling to room temperature was followed by filtration. To the filtrate, 30 mL of 1 mol/L NaOH aqueous solution was added to dissolve the precipitate. after 1 h, 4.2 mL of acetic acid was slowly added dropwise to produce a light brown precipitate, which was filtered and dried to afford the target product, 7-methoxy-2,4(1H,3H)-quinazolinedione (0.55 g, 2.9 mmol, 48% yield). The product characterization data were as follows: 1H NMR (500 MHz, DMSO) δ 11.10 (brs, 1H, NH), 10.55 (brs, 1H, NH), 7.8 (d, J = 8.63 Hz, 1H, Ar-H), 6.77 (dd, J = 2.44, 8.84 Hz, 1H, Ar-H), 6.64 (d, J = 2.43 Hz, 1H, Ar-H), 3.82 (s, 3H, OCH3).13C NMR (125 MHz, DMSO) δ 164.8, 162.8, 151.0, 143.3, 129.3, 111.0, 108.2, 98.8, 56.1. HRMS-ESI (m/z) Calculated Value C9H8N2O3 [M + H]+ : 193.0489, measured value: 193.0511.
References
[1] Patent: WO2016/151144, 2016, A1. Location in patent: Page/Page column 55; 56
[2] Journal of Medicinal Chemistry, 2014, vol. 57, # 12, p. 5141 - 5156
7-METHOXYQUINAZOLINE-2,4(1H,3H)-DIONE Preparation Products And Raw materials
Raw materials
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