ChemicalBook > CAS DataBase List > 2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER

2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER

Product Name
2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER
CAS No.
788081-99-2
Chemical Name
2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER
Synonyms
Methyl 2-(broMoMethyl)-5-Methoxybenzoate;2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER;Benzoic acid, 2-(bromomethyl)-5-methoxy-, methyl ester
CBNumber
CB52460827
Molecular Formula
C10H11BrO3
Formula Weight
259.1
MOL File
788081-99-2.mol
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2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER Property

Boiling point:
342.5±32.0 °C(Predicted)
Density 
1.432±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific
Product number
2336AC
Product name
Methyl2-(bromomethyl)-5-methoxybenzoate
Packaging
25g
Price
$691
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0030254
Product name
BENZOIC ACID, 2-(BROMOMETHYL)-5-METHOXY-, METHYL ESTER
Purity
95.00%
Packaging
1G
Price
$1089.05
Updated
2021/12/16
AK Scientific
Product number
2336AC
Product name
Methyl2-(bromomethyl)-5-methoxybenzoate
Packaging
100g
Price
$2051
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0030254
Product name
BENZOIC ACID, 2-(BROMOMETHYL)-5-METHOXY-, METHYL ESTER
Purity
95.00%
Packaging
5G
Price
$2233.89
Updated
2021/12/16
Crysdot
Product number
CD12030904
Product name
Methyl2-(bromomethyl)-5-methoxybenzoate
Purity
98%
Packaging
25g
Price
$2075
Updated
2021/12/16
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2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER Chemical Properties,Usage,Production

Synthesis

73502-03-1

788081-99-2

General procedure for the synthesis of methyl 2-bromomethyl-5-methoxybenzoate from methyl 2-methyl-5-methoxybenzoate: Preparation of intermediate 12: Compound 11 (4.4 g, 24.2 mmol) was dissolved in carbon tetrachloride (80 mL) and N-bromosuccinimide (4.48 g, 24.2 mmol) and benzoyl peroxide (276 mg 1.13 mmol). The reaction mixture was heated to reflux and stirred for 3 hours. After completion of the reaction, the solid insoluble material was removed by filtration and the filter cake was washed with ether. The organic phases were combined, washed with water, dried over anhydrous sodium sulfate and concentrated under reduced pressure to give the target product 12 (6.1 g, 98% yield). Product characterization data: mass spectrum (LCMS) m/z 260 ([M+H]+), 1H NMR (CDCl3) δ 4.50 (2H, s, CH2Br), 3.73 (3H, s, OCH3), 3.88 (3H, s, CO2CH3), 6.86-7.50 (m, 3H, Ar-H).

References

[1] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 17, p. 5286 - 5289
[2] Patent: WO2009/14637, 2009, A2. Location in patent: Page/Page column 70
[3] Patent: WO2010/54279, 2010, A1. Location in patent: Page/Page column 100
[4] Bioorganic and Medicinal Chemistry Letters, 2010, vol. 20, # 24, p. 7283 - 7287
[5] Patent: WO2006/138549, 2006, A1. Location in patent: Page/Page column 73

2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER Preparation Products And Raw materials

Raw materials

Preparation Products

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2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER Suppliers

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788081-99-2, 2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTERRelated Search:


  • 2-BROMOMETHYL-5-METHOXY-BENZOIC ACID METHYL ESTER
  • Benzoic acid, 2-(bromomethyl)-5-methoxy-, methyl ester
  • Methyl 2-(broMoMethyl)-5-Methoxybenzoate
  • 788081-99-2