ChemicalBook > CAS DataBase List > 2,7-NAPHTHYRIDINE, 1-CHLORO-

2,7-NAPHTHYRIDINE, 1-CHLORO-

Product Name
2,7-NAPHTHYRIDINE, 1-CHLORO-
CAS No.
69042-30-4
Chemical Name
2,7-NAPHTHYRIDINE, 1-CHLORO-
Synonyms
1-Chlorocopyrine;1-Chloro-2,7-naphthyri;1-CHLORO-2,7-NAPHTHYRIDINE;1-Chloro-[2,7]naphthyridi...;2,7-NAPHTHYRIDINE, 1-CHLORO-
CBNumber
CB52463611
Molecular Formula
C8H5ClN2
Formula Weight
164.59
MOL File
69042-30-4.mol
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2,7-NAPHTHYRIDINE, 1-CHLORO- Property

Boiling point:
326.4±22.0 °C(Predicted)
Density 
1.349
storage temp. 
Inert atmosphere,Room Temperature
pka
2.52±0.30(Predicted)
form 
solid
color 
Light yellow to yellow
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Safety

HS Code 
2933998090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C588190
Product name
1-Chloro-2,7-naphthyridine
Packaging
50mg
Price
$65
Updated
2021/12/16
SynQuest Laboratories
Product number
3H32-5-C2
Product name
1-Chloro-[2,7]naphthyridine
Packaging
250mg
Price
$128
Updated
2021/12/16
Matrix Scientific
Product number
068666
Product name
1-Chloro-[2,7]naphthyridine
Purity
>95%
Packaging
250mg
Price
$190
Updated
2021/12/16
Matrix Scientific
Product number
068666
Product name
1-Chloro-[2,7]naphthyridine
Purity
>95%
Packaging
500mg
Price
$293
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC46880
Product name
1-Chloro-2,7-naphthyridine
Packaging
250mg
Price
$300
Updated
2021/12/16
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2,7-NAPHTHYRIDINE, 1-CHLORO- Chemical Properties,Usage,Production

Synthesis

369648-60-2

69042-30-4

General procedure for the synthesis of 1-chloro-2,7-naphthyridine from 2,7-naphthyridin-1(2H)-one hydrochloride: intermediate 2 (5.2 g, 28 mmol) was reacted with phosphorus trichloride (75 ml) for 24 h at 110°C with stirring. After completion of the reaction, the volatiles were removed by distillation under reduced pressure to give a dark colored oily substance. The oily substance was slowly poured into a mixture of saturated aqueous sodium bicarbonate (100 ml, containing 20 g of solid sodium bicarbonate) and ethyl acetate (100 ml) in a pre-cooled ice bath. After separation of the aqueous layer, the aqueous layer was re-extracted with ethyl acetate (2 x 75 ml). All organic phases were combined, washed with brine (15 ml), dried over anhydrous sodium sulfate and concentrated under reduced pressure to give 1-chloro-2,7-naphthyridine as a yellow solid (4.0 g, 85% yield).1H NMR (CDCl3) δ: 9.45 (1H, s), 8.81 (1H, d, J = 5.7 Hz), 8.47 (1H, d, J = 5.7 Hz), 7.66 (1H, d, J = 5.7 Hz), 7.60 (1H, d, J = 5.7 Hz); m/z (ES+, 70V) 165 and 167 (MH+).

References

[1] Patent: WO2004/7494, 2004, A1. Location in patent: Page 15-16
[2] Patent: US2009/221828, 2009, A1. Location in patent: Page/Page column 7
[3] Patent: WO2004/7428, 2004, A1. Location in patent: Page 44

2,7-NAPHTHYRIDINE, 1-CHLORO- Preparation Products And Raw materials

Raw materials

Preparation Products

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2,7-NAPHTHYRIDINE, 1-CHLORO- Suppliers

China 69 Germany 1 India 1 United Kingdom 1 United States 8 Global 80
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Shanghai Apichemical CO.,LTD
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View Lastest Price from 2,7-NAPHTHYRIDINE, 1-CHLORO- manufacturers

Nanjing jinheyou Trading Co., Ltd.
Product
2,7-NAPHTHYRIDINE, 1-CHLORO- 69042-30-4
Price
US $0.00/g
Min. Order
1g
Purity
95%min
Supply Ability
20kg/month
Release date
2019-12-30

69042-30-4, 2,7-NAPHTHYRIDINE, 1-CHLORO-Related Search:

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