1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
- Product Name
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
- CAS No.
- 364-11-4
- Chemical Name
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE
- Synonyms
- 2-Bromo-5-iodobenzotrifluoride;1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE;Benzene, 1-bromo-4-iodo-2-(trifluoromethyl)-;1-Bromo-4-iodo-2-(trifluoromethyl)benzene, 2-Bromo-5-iodo-alpha,alpha,alpha-trifluorotoluene
- CBNumber
- CB52467048
- Molecular Formula
- C7H3BrF3I
- Formula Weight
- 350.9
- MOL File
- 364-11-4.mol
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Property
- Melting point:
- 78-80℃ (water )
- Boiling point:
- 245.1±35.0℃ (760 Torr)
- Density
- 2.176±0.06 g/cm3 (20 ºC 760 Torr)
- Flash point:
- 102.1±25.9℃
- storage temp.
- Keep in dark place,Sealed in dry,2-8°C
- form
- crystals
- color
- Faint orange/pale salmon (hint of pink)
Safety
- HS Code
- 2903998090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- B685243
- Product name
- 1-Bromo-4-iodo-2-trifluoromethylbenzene
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- PC51000
- Product name
- 2-Bromo-5-iodobenzotrifluoride
- Packaging
- 1g
- Price
- $15
- Updated
- 2021/12/16
- Product number
- 1800-U-X1
- Product name
- 2-Bromo-5-iodobenzotrifluoride
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 094053
- Product name
- 2-Bromo-5-iodobenzotrifluoride
- Purity
- 98%
- Packaging
- 5g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- PC51000
- Product name
- 2-Bromo-5-iodobenzotrifluoride
- Packaging
- 5g
- Price
- $37
- Updated
- 2021/12/16
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Chemical Properties,Usage,Production
Synthesis
393-36-2
364-11-4
The general procedure for the synthesis of 2-bromo-5-iodobenzotrifluoride from 5-amino-2-bromobenzotrifluoride was as follows: first, 4-bromo-3-(trifluoromethyl)aniline (500 mg, 2.08 mmol) was dissolved in a mixture of preheated concentrated sulfuric acid (37% w/w, 0.51 mL, 4.6 eq.) and water (2.3 mL, concentration = 3.4 M). Under vigorous stirring, the reaction mixture was cooled to -10 °C (using an ice-salt bath), at which point the aniline bisulfate precipitated as a slurry. Subsequently, an aqueous solution of sodium nitrite (NaNO2, 158 mg, 1.1 eq.) was added slowly and dropwise (1.06 mL, concentration = 2.15 M). After continued stirring at -8 °C for 40 min, an aqueous solution of potassium iodide (KI, 495 mg, 1.43 equiv) (0.4 mL, concentration = 8 M) and copper powder (4 mg) were added. The reaction mixture was gradually warmed to room temperature (ice bath removed) and stirred for 30 minutes. Next, the reaction was heated to reflux (102 °C) and kept for 1 hour. Upon completion of the reaction, it was cooled to room temperature, diluted with water and the aqueous layer was extracted with dichloromethane (DCM, 3 x 20 mL). The combined organic phases were washed sequentially with saturated sodium thiosulfate (Na2S2O3, 20 mL) and brine (20 mL), dried over anhydrous magnesium sulfate (MgSO4), filtered and concentrated under reduced pressure. The crude product was purified by column chromatography (eluent: hexane) to afford the target compound 2-bromo-5-iodobenzotrifluoride in 93% yield (679 mg) as an orange solid. The structure of the product was confirmed by 1H NMR and 13C NMR.
References
[1] Patent: WO2013/167730, 2013, A1. Location in patent: Page/Page column 90
[2] Angewandte Chemie - International Edition, 2009, vol. 48, # 43, p. 8070 - 8073
[3] Journal of Medicinal Chemistry, 2014, vol. 57, # 21, p. 9096 - 9104
[4] Patent: WO2016/63300, 2016, A1. Location in patent: Page/Page column 8
[5] Journal of Medicinal Chemistry, 2012, vol. 55, # 1, p. 233 - 249
1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE manufacturers
- Product
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE 364-11-4
- Price
- US $1.00/Kg
- Min. Order
- 1Kg
- Purity
- 98%
- Supply Ability
- 20T
- Release date
- 2024-06-11
- Product
- 1-Bromo-4-iodo-2-trifluoromethylbenzene 364-11-4
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 98.5%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 1-BROMO-4-IODO-2-(TRIFLUOROMETHYL)BENZENE 364-11-4
- Price
- US $7.00/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- JD724
- Release date
- 2019-09-02