ChemicalBook > CAS DataBase List > (R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE

(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE

Product Name
(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE
CAS No.
460746-46-7
Chemical Name
(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE
Synonyms
ABT 239;ABT-239 (ABT239;ABT-239, 10 mM in DMSO;(R)-4-[2-[2-(2-Methylpyrrolidinyl)ethyl]benzofuran-5-yl]benzonitrile;(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE;(R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)- ethyl)benzofuran-5-yl)benzonitril;Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-;4-(2-{2-[(2R)-2-Methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile
CBNumber
CB52468757
Molecular Formula
C22H22N2O
Formula Weight
330.42
MOL File
460746-46-7.mol
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(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE Property

Boiling point:
493.5±40.0 °C(Predicted)
Density 
1.18±0.1 g/cm3(Predicted)
storage temp. 
2-8°C
solubility 
DMSO: ≥ 100 mg/mL (302.65 mM); Water: < 0.1 mg/mL (insoluble)
pka
10.13±0.40(Predicted)
form 
Solid
color 
Light yellow to khaki
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P310Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-5904
Product name
ABT-239
Purity
99.06%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-5904
Product name
ABT-239
Purity
99.06%
Packaging
10mg
Price
$250
Updated
2021/12/16
Matrix Scientific
Product number
093492
Product name
(R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)-ethyl)benzofuran-5-yl)benzonitrile
Purity
95+%
Packaging
250mg
Price
$756
Updated
2021/12/16
Biorbyt Ltd
Product number
orb611652
Product name
ABT-239
Packaging
100mg
Price
$765
Updated
2021/12/16
ChemScene
Product number
CS-5904
Product name
ABT-239
Purity
99.06%
Packaging
50mg
Price
$950
Updated
2021/12/16
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(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE Chemical Properties,Usage,Production

Uses

ABT-239 is a novel, highly efficacious, non-imidazole class of H3R antagonist and a transient receptor potential vanilloid type 1 (TRPV1) antagonist.

in vivo

ABT-239 (3 mg/kg, i.p.) significantly delays onset of seizure, reduces behavioral seizures elicited by KA, and reduces in the incidence of head bobbing and forelimb clonus in mice. ABT-239 (1 mg/kg, i.p.) in conbination with sub-therapeutic dose of SVP (150 mg/kg, i.p.), significantly decreases the number of immobility, head bobbing and forelimb clonus, where as a higher dose combination of ABT-239 (3 mg/kg, i.p.) causes enhanced reduction in all the stages. ABT-239 (3 mg/kg, i.p.) and TDZD-8 (10 mg/kg, i.p.) have more powerful reduction in the number of pyknotic neurons in mice hippocampi. The high dose combination of ABT-239 and TDZD-8 produces the most pronounced increase in Bcl-2 expression as well as decrease in the level of Bax[1]. ABT-239 (3 mg/kg, i.p.) administration transforms a short-term learning event into a long-term remembered experience in WT but not in histamine-depleted mice[2]. Concomitant administration of either ABT-239 (1 and 3 mg/kg, i.p.) and nicotine (0.035 mg/kg, i.p.), or ABT-239 (0.1 mg/kg, i.p.) and nicotine (0.0175 mg/kg, i.p.) further increases nicotine-induced improvement in both memory acquisition and consolidation[3].

IC 50

H3 receptor

References

[1] Bhowmik M, et al. Histamine H3 receptor antagonism by ABT-239 attenuates kainic acid induced excitotoxicity in mice. Brain Res. 2014 Sep 18;1581:129-40. DOI:10.1016/j.brainres.2014.06.012
[2] Provensi G, et al. Donepezil, an acetylcholine esterase inhibitor, and ABT-239, a histamine H3 receptor antagonist/inverse agonist, require the integrity of brain histamine system to exert biochemical and procognitive effects in the mouse. Neuropharmacolo DOI:10.1016/j.neuropharm.2016.06.010
[3] Kruk M, e tal. Effects of the histamine H2 receptor antagonist ABT-239 on cognition and nicotine-induced memory enhancement in mice. Pharmacol Rep. 2012;64(6):1316-25. DOI:10.1016/s1734-1140(12)70929-5
[4] Munari L, et al. Selective brain region activation by histamine H2 receptor antagonist/inverse agonist ABT-239 enhances acetylcholine and histamine release and increases c-Fos expression. Neuropharmacology. 2013 Jul;70:131-40. DOI:10.1016/j.neuropharm.2013.01.021

(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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(R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE Suppliers

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460746-46-7, (R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILERelated Search:


  • (R)-4-(2-(2-(2-METHYLPYRROLIDIN-1-YL)ETHYL)BENZOFURAN-5-YL)BENZONITRILE
  • ABT 239
  • 4-(2-{2-[(2R)-2-Methyl-1-pyrrolidinyl]ethyl}-1-benzofuran-5-yl)benzonitrile
  • (R)-4-(2-(2-(2-Methylpyrrolidin-1-yl)- ethyl)benzofuran-5-yl)benzonitril
  • (R)-4-[2-[2-(2-Methylpyrrolidinyl)ethyl]benzofuran-5-yl]benzonitrile
  • ABT-239 (ABT239
  • Benzonitrile, 4-[2-[2-[(2R)-2-methyl-1-pyrrolidinyl]ethyl]-5-benzofuranyl]-
  • ABT-239, 10 mM in DMSO
  • 460746-46-7