ChemicalBook > CAS DataBase List > 1-(2-Chloro-6-hydroxyphenyl)ethanone
1-(2-Chloro-6-hydroxyphenyl)ethanone
- Product Name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- CAS No.
- 55736-04-4
- Chemical Name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Synonyms
- oro-6-hydroxyphenyL;1-(2-Chloro-6-hydroxyphenyl);2’-Chloro-6’-hydroxyacetophenone;2'-Chloro-6'-hydroxyacetophenone;1-(2-Chloro-6-hydroxyphenyl)ethanone;Ethanone, 1-(2-chloro-6-hydroxyphenyl)-;1-(2-Chloro-6-hydroxyphenyl)ethan-1-one 97+%
- CBNumber
- CB52470017
- Molecular Formula
- C8H7ClO2
- Formula Weight
- 170.59
- MOL File
- 55736-04-4.mol
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1-(2-Chloro-6-hydroxyphenyl)ethanone Property
- Boiling point:
- 225.4±20.0 °C(Predicted)
- Density
- 1.298±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 9.20±0.10(Predicted)
- Appearance
- Off-white to yellow Solid
- InChI
- InChI=1S/C8H7ClO2/c1-5(10)8-6(9)3-2-4-7(8)11/h2-4,11H,1H3
- InChIKey
- RUSSVKYJPIADHS-UHFFFAOYSA-N
- SMILES
- C(=O)(C1=C(O)C=CC=C1Cl)C
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Safety
- HS Code
- 2914500090
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
TRC
- Product number
- C585620
- Product name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
TRC
- Product number
- C585620
- Product name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Packaging
- 100mg
- Price
- $75
- Updated
- 2021/12/16
TRC
- Product number
- C585620
- Product name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Packaging
- 500mg
- Price
- $165
- Updated
- 2021/12/16
AK Scientific
- Product number
- J94265
- Product name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Packaging
- 250mg
- Price
- $30
- Updated
- 2021/12/16
AK Scientific
- Product number
- J94265
- Product name
- 1-(2-Chloro-6-hydroxyphenyl)ethanone
- Packaging
- 1g
- Price
- $75
- Updated
- 2021/12/16
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1-(2-Chloro-6-hydroxyphenyl)ethanone Chemical Properties,Usage,Production
Uses
1-(2-Chloro-6-hydroxyphenyl)ethanone is used for synthesis and structure-activity relationship of novel spiropiperidine-based stearoyl-CoA desaturase-1 inhibitors.
Preparation
Preparation by diazotization of 2-amino-6-chloro-acetophenone, followed by hydrolysis of the obtained diazonium salt (55%).
Synthesis
89999-90-6
75-16-1
55736-04-4
1. To a solution of 2-chloro-6-hydroxybenzonitrile (614 mg, 4 mmol) in tetrahydrofuran (THF, 10 mL) under argon protection is slowly added a solution of methylmagnesium bromide in toluene/THF (3:1, 1.4 M, 6.4 mL, 9 mmol). Note: Gas escapes during the reaction. 2. Stir the reaction mixture at room temperature until the escape of gas ceases. 3. Transfer the reaction mixture to a sealed tube and stir overnight at 65°C. 4. 4. upon completion of the reaction, the reaction is quenched with water and acidified with aqueous hydrochloric acid. 5. The organic layer containing 1-(2-chloro-6-hydroxyphenyl)ethanone was extracted with dichloromethane (DCM). 6. The product was purified by column chromatography using dichloromethane/hexane (1:1) as eluent to afford 1-(2-chloro-6-hydroxyphenyl)ethanone (100 mg, 15% yield).
References
[1] Patent: WO2010/56631, 2010, A1. Location in patent: Page/Page column 132-134
1-(2-Chloro-6-hydroxyphenyl)ethanone Preparation Products And Raw materials
Raw materials
Preparation Products
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