4-Bromo-2-(methylsulfonyl)pyrimidine
- Product Name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- CAS No.
- 1208538-52-6
- Chemical Name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- Synonyms
- 4-Bromo-2-(methylsulfonyl);4-Bromo-2-(methylsulfonyl)pyrimidine;Pyrimidine, 4-bromo-2-(methylsulfonyl)-;4-Bromo-2-(methylsulfonyl)pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB52470123
- Molecular Formula
- C5H5BrN2O2S
- Formula Weight
- 237.07
- MOL File
- 1208538-52-6.mol
4-Bromo-2-(methylsulfonyl)pyrimidine Property
- Melting point:
- 111-112 °C
- Boiling point:
- 393.7±34.0 °C(Predicted)
- Density
- 1.771±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -4.97±0.20(Predicted)
- Appearance
- Off-white to light yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- B697758
- Product name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- HCH0143642
- Product name
- 4-BROMO-2-(METHYLSULFONYL)PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 250MG
- Price
- $376.95
- Updated
- 2021/12/16
- Product number
- 073266
- Product name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- Purity
- 95+%
- Packaging
- 250mg
- Price
- $410
- Updated
- 2021/12/16
- Product number
- X9449
- Product name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- Packaging
- 250mg
- Price
- $204
- Updated
- 2021/12/16
- Product number
- 073266
- Product name
- 4-Bromo-2-(methylsulfonyl)pyrimidine
- Purity
- 95+%
- Packaging
- 1g
- Price
- $919
- Updated
- 2021/12/16
4-Bromo-2-(methylsulfonyl)pyrimidine Chemical Properties,Usage,Production
Synthesis
959236-97-6
1208538-52-6
General procedure for the synthesis of 4-bromo-2-(methylthio)pyrimidine from 2-methylthio-4-bromopyrimidine: ammonium molybdate tetrahydrate (1.09 g, 0.88 mmol, 0.03 eq.) was added in batches to a stirred solution of 30% H2O2 (6 g, 29.4 mmol, 1 eq.) at 0 °C for 20 min. Subsequently, a solution of 4-bromo-2-(methylthio)pyrimidine (6 g, 29.41 mmol, 1 eq.) was slowly added, keeping the reaction temperature at 0 °C. After addition, the reaction mixture was brought to room temperature and stirred for 3 hours. The reaction progress was monitored by TLC. Upon completion of the reaction, the reaction mixture was concentrated to a crude residue, diluted with cold water and then extracted with dichloromethane (DCM, 3 x 100 mL). The organic layers were combined, washed sequentially with 5% H2SO4 solution and water, dried over anhydrous Na2SO4 and concentrated to give the crude product. The crude product was purified by silica gel column chromatography (100-200 mesh) with the eluent being a petroleum ether solution of 0-40% ethyl acetate, resulting in 4-bromo-2-(methylsulfonyl)pyrimidine (6 g, 86% yield) as an off-white solid.LCMS: [M + H]+ 238.84.
References
[1] ChemMedChem, 2016, vol. 11, # 22, p. 2522 - 2533
[2] Organic Letters, 2011, vol. 13, # 19, p. 5000 - 5003
[3] Patent: WO2017/147700, 2017, A1. Location in patent: Paragraph 001095
4-Bromo-2-(methylsulfonyl)pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Bromo-2-(methylsulfonyl)pyrimidine manufacturers
- Product
- 4-Bromo-2-(methylsulfonyl)pyrimidine 1208538-52-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons Min
- Release date
- 2021-12-02
- Product
- 4-Bromo-2-(methylsulfonyl)pyrimidine 1208538-52-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-11
- Product
- 4-Bromo-2-(methylsulfonyl)pyrimidine 1208538-52-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-09