7-bromo-3,4-dihydroquinazolin-2(1H)-one

Product Name: 7-bromo-3,4-dihydroquinazolin-2(1H)-one
CAS No.: 1207175-68-5
Chemical Name: 7-bromo-3,4-dihydroquinazolin-2(1H)-one
Synonyms: 7-Bromo-3,4-dihydroquinazolin-2(1H);7-BroMo-3,4-dihydro-2(1H)-quinazolinone;7-bromo-3,4-dihydroquinazolin-2(1H)-one;2(1H)-Quinazolinone, 7-bromo-3,4-dihydro-
CBNumber: CB52470512
Molecular Formula: C8H7BrN2O
Formula Weight: 227.06
MOL File: 1207175-68-5.mol

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7-bromo-3,4-dihydroquinazolin-2(1H)-one Property

Boiling point:: 294.0±40.0 °C(Predicted)
Density: 1.610
storage temp.: Sealed in dry,Room Temperature
pka: 13.11±0.20(Predicted)
Appearance: White to off-white Powder

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

AK Scientific

Product number: 8526DG
Product name: 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
Packaging: 10g
Price: $2535
Updated: 2021/12/16

Crysdot

Product number: CD11331911
Product name: 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
Purity: 97+%
Packaging: 100mg
Price: $79
Updated: 2021/12/16

Crysdot

Product number: CD11331911
Product name: 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
Purity: 97+%
Packaging: 250mg
Price: $127
Updated: 2021/12/16

Abosyn

Product number: 61-5330
Product name: 7-bromo-3,4-dihydroquinazolin-2(1H)-one
Purity: 98%
Packaging: 1g
Price: $200
Updated: 2021/12/16

Crysdot

Product number: CD11331911
Product name: 7-Bromo-3,4-dihydroquinazolin-2(1H)-one
Purity: 97+%
Packaging: 1g
Price: $317
Updated: 2021/12/16

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7-bromo-3,4-dihydroquinazolin-2(1H)-one Chemical Properties,Usage,Production

Synthesis

624813-49-6

530-62-1

1207175-68-5

At room temperature, 2-(aminomethyl)-5-bromoaniline (0.90 g, 4.5 mmol) was dissolved in tetrahydrofuran (10 mL), followed by the addition of N,N'-carbonyldiimidazole (0.80 g, 4.9 mmol). The reaction mixture was heated to 80 °C with continuous stirring for 6 hours. Upon completion of the reaction, the mixture was cooled to room temperature, the resulting solid was collected by filtration and washed with ether to afford 7-bromo-3,4-dihydroquinazolin-2(1H)-one (0.73 g, 72% yield) as an off-white solid.IR (KBr) νmax/cm-1 : 3308, 3158 (NH), 3022 (Ar-H), 1682 (C=O). 1514, 1411 (C=C).1H NMR (500 MHz, DMSO-d6) δ: 5.25 (s, 2H, CH2); 6.82 (d, 1H, J=8.2 Hz, H-5); 7.42 (m, 2H, H-4, H-6); 10.29 (br.s, 1H, NH).13C NMR (125.7 MHz. DMSO-d6) δ: 66.85 (CH2), 113.70 (C-10), 115.70 (C-8), 121.03 (C-7), 127.52 (C-6), 131.41 (C-5), 135.88 (C-9), 151.42 (C=O). Elemental analysis calculated values (%) C8H7BrN2O (225.97): C: 42.32, H: 3.11, N: 12.34; measured values (%): C: 42.27, H: 3.16, N: 12.28.

References

[1] Medicinal Chemistry, 2014, vol. 10, # 5, p. 484 - 496
[2] Patent: US8916704, 2014, B1. Location in patent: Page/Page column 9

7-bromo-3,4-dihydroquinazolin-2(1H)-one Preparation Products And Raw materials

Raw materials

Preparation Products

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