Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Product Name
- Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- CAS No.
- 105486-72-4
- Chemical Name
- Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Synonyms
- Ethyl 5-bromo-1-methyl-1h-pyrazole-4-formate;ethyl 5-bromo-1-methyl-pyrazole-4-carboxylate;Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate;5-Bromo-1-methyl-1H-pyrazole-4-carboxylic acid ethyl ester;1H-PYRAZOLE-4-CARBOXYLIC ACID, 5-BROMO-1-METHYL-, ETHYL ESTER;5-bromo-1-methyl-1H-Pyrazole-4-carboxylic acid ethyl ester (9CI ACI);1H-Pyrazole-4-carboxylic acid, 5-bromo-1-methyl-, ethyl ester (9CI, ACI)
- CBNumber
- CB52471504
- Molecular Formula
- C7H9BrN2O2
- Formula Weight
- 233.06
- MOL File
- 105486-72-4.mol
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Property
- Boiling point:
- 290.7±20.0 °C(Predicted)
- Density
- 1.58±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -1.13±0.10(Predicted)
- Appearance
- White to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- HCH0368923
- Product name
- ETHYL-5-BROMO-1-METHYL-1H-PYRAZOLE-4-CARBOXYLATE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $500.6
- Updated
- 2021/12/16
- Product number
- 1249AA
- Product name
- Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Packaging
- 1g
- Price
- $284
- Updated
- 2021/12/16
- Product number
- A155081
- Product name
- Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95%
- Packaging
- 5g
- Price
- $464
- Updated
- 2021/12/16
- Product number
- 105486724
- Product name
- 5-Bromo-1-methyl-1h-pyrazole-4-carboxylicacidethylester
- Packaging
- 5g
- Price
- $507.91
- Updated
- 2021/12/16
- Product number
- CD11359068
- Product name
- Ethyl5-bromo-1-methyl-1H-pyrazole-4-carboxylate
- Purity
- 95+%
- Packaging
- 5g
- Price
- $535
- Updated
- 2021/12/16
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Chemical Properties,Usage,Production
Synthesis
31037-02-2
105486-72-4
General procedure for the synthesis of ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate from ethyl 5-amino-1-methylpyrazole-4-carboxylate: Intermediate 1: (5-bromo-1-methyl-1H-pyrazol-4-yl)-(octahydro-quinolin-1-yl)methanone; Step 1: To a mixed solution containing tert-butyl nitrite (29.5 mL, 221.5 mmol), copper bromide (39.7 g, 177.5 mmol), and acetonitrile, ethyl 5-amino-1-methyl-1H-pyrazole-4-carboxylate (25 g, 148 mmol) was slowly added over a 30-minute period. The reaction mixture was stirred at room temperature for 2 hours, followed by warming up to 65 °C and continued stirring for 1 hour. After completion of the reaction, the mixture was poured into 6N HCl (400 mL) and extracted with dichloromethane. The organic phase was concentrated in vacuum and the resulting crude product was purified by fast chromatography using a 0-20% ethyl acetate/hexane gradient elution to give ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate (28 g, 81% yield).
References
[1] Patent: US2006/223852, 2006, A1. Location in patent: Page/Page column 10
[2] Patent: WO2013/189904, 2013, A1. Location in patent: Page/Page column 49
[3] Patent: US2012/214791, 2012, A1. Location in patent: Page/Page column 23
[4] Journal of Medicinal Chemistry, 2018, vol. 61, # 3, p. 1001 - 1018
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Preparation Products And Raw materials
Raw materials
Preparation Products
Ethyl 5-bromo-1-methyl-1H-pyrazole-4-carboxylate Suppliers
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