2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Product Name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- CAS No.
- 938443-20-0
- Chemical Name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Synonyms
- 100232;2,4,7-Trichloropyrido[2,3...;2,4,7-Trichloropyrido[2,3-d]pyrimidine;Pyrido[2,3-d]pyriMidine, 2,4,7-trichloro-;2,4,7-Trichloropyrido[2,3-d]pyrimidine ISO 9001：2015 REACH
- CBNumber
- CB52474792
- Molecular Formula
- C7H2Cl3N3
- Formula Weight
- 234.47
- MOL File
- 938443-20-0.mol
2,4,7-Trichloropyrido[2,3-d]pyrimidine Property
- Boiling point:
- 316.4±42.0 °C(Predicted)
- Density
- 1.685±0.06 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- pka
- -2.53±0.30(Predicted)
- Appearance
- White to off-white Solid
- InChI
- InChI=1S/C7H2Cl3N3/c8-4-2-1-3-5(9)12-7(10)13-6(3)11-4/h1-2H
- InChIKey
- DNFDLCRLLQVUQK-UHFFFAOYSA-N
- SMILES
- C1(Cl)=NC(Cl)=C2C=CC(Cl)=NC2=N1
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H318Causes serious eye damage
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- SYX00244
- Product name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Purity
- Aldrich
- Packaging
- 1g
- Price
- $1490
- Updated
- 2023/01/07
- Product number
- T773910
- Product name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Packaging
- 100mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- T773910
- Product name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Packaging
- 1g
- Price
- $1055
- Updated
- 2021/12/16
- Product number
- 070083
- Product name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Purity
- 95%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
- Product number
- 6004AC
- Product name
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine
- Packaging
- 250mg
- Price
- $203
- Updated
- 2021/12/16
2,4,7-Trichloropyrido[2,3-d]pyrimidine Chemical Properties,Usage,Production
Uses
2,4,7-Trichloropyrido[2,3-d]pyrimidine is used in the synthetic preparation of dual mTORC1/mTORC2 inhibitors and the discovery of AZD8055 and AZD2014 as potential antitumor agents.
Synthesis
938443-19-7
938443-20-0
The general procedure for the synthesis of 2,4,7-trichloropyrido[2,3-d]pyrimidine (Inter.5) using 7-chloropyrido[2,3-d]pyrimidine-2,4(1H,3H)-dione (Inter.4) as a starting material is as follows: To a stirred anhydrous toluene suspension of 0.5 M Inter.4 (1 equiv.) in an inert atmosphere was slowly added diisopropylethylamine (3 equivalent). The reaction mixture was heated to 70 °C and maintained for 30 min and subsequently cooled to room temperature. Next, phosphorous oxychloride (POCl3, 3 eq.) was added and the reaction mixture was heated to 100 °C for 2.5 hours. Upon completion of the reaction, the mixture was cooled and concentrated under vacuum to give a crude product slurry. The crude product was suspended in ethyl acetate (EtOAc) and filtered through a thin diatomaceous earth pad. The filtrate was concentrated under vacuum to give a brown oil. The oily substance was dissolved in dichloromethane (CH2Cl2) and stirred on silica gel for 30 minutes. Afterwards, the silica gel was removed by filtration and the filtrate was concentrated. The crude product was purified by fast chromatography (silica gel, SiO2) to afford analytically pure 2,4,7-trichloropyrido[2,3-d]pyrimidine (48% yield, 96% purity). Mass spectrometry (LC-MS, ESP) analysis resulted in: m/z 234 [M + H]+, retention time (R/T) = 4.21 min.
References
[1] Patent: WO2007/60404, 2007, A1. Location in patent: Page/Page column 57; 59
[2] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 101
[3] Bioorganic and Medicinal Chemistry Letters, 2013, vol. 23, # 5, p. 1212 - 1216
[4] Patent: WO2008/23161, 2008, A1. Location in patent: Page/Page column 102-103
[5] Patent: CN102887895, 2016, B. Location in patent: Paragraph 0310; 0313; 0314
2,4,7-Trichloropyrido[2,3-d]pyrimidine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2,4,7-Trichloropyrido[2,3-d]pyrimidine manufacturers
- Product
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine 938443-20-0
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1Ton
- Release date
- 2022-09-22
- Product
- 2,4,7-trichloropyrido[2,3-d]pyrimidine 938443-20-0
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20T
- Release date
- 2019-12-27
- Product
- 2,4,7-Trichloropyrido[2,3-d]pyrimidine 938443-20-0
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons min
- Release date
- 2021-09-03