ChemicalBook > CAS DataBase List > Hemopressin (human, bovine, porcine)
Hemopressin (human, bovine, porcine)
- Product Name
- Hemopressin (human, bovine, porcine)
- CAS No.
- 1314035-51-2
- Chemical Name
- Hemopressin (human, bovine, porcine)
- Synonyms
- Hemopressin (human, bovine, porcine);H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH;L-Histidine, L-prolyl-L-valyl-L-asparaginyl-L-phenylalanyl-L-lysyl-L-leucyl-L-leucyl-L-seryl-
- CBNumber
- CB52476877
- Molecular Formula
- C50H79N13O12
- Formula Weight
- 1054.24
- MOL File
- 1314035-51-2.mol
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Hemopressin (human, bovine, porcine) Property
- Boiling point:
- 1491.3±65.0 °C(Predicted)
- Density
- 1.258±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- pka
- 2.77±0.10(Predicted)
- form
- Powder
- color
- White to off-white
- Water Solubility
- Soluble to 1 mg/ml in water
- Sequence
- H-Pro-Val-Asn-Phe-Lys-Leu-Leu-Ser-His-OH
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N-Bromosuccinimide Price
ApexBio Technology
- Product number
- B5476
- Product name
- Hemopressin(human,mouse)
- Packaging
- 1mg
- Price
- $266
- Updated
- 2021/12/16
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Hemopressin (human, bovine, porcine) Chemical Properties,Usage,Production
Uses
Hemopressin is a nonapeptide derived from the α1-chain of hemoglobin, is originally isolated from rat brain homogenates. Hemopressin is orally active, selective and inverse agonist of CB1 cannabinoid receptors. Hemopressin exerts antinociceptive action in inflammatory pain models[1][2].
in vivo
Hemopressin causes hypotension in anesthetized rats and is metabolized in vivo and in vitro by endopeptidase 24.15 (EP24.15), neurolysin (EP24.16), and angiotensin-converting enzyme (ACE)[1].
Oral administration of Hemopressin inhibits mechanical hyperalgesia of CCI-rats up to 6h. Hemopressin treatment also decreases Egr-1 immunoreactivity (Egr-1Ir) in the superficial layer of the dorsal horn of the spinal cord of CCI rats[2].
storage
Store at -20°C
References
[1] Garron T Dodd, et al. The peptide hemopressin acts through CB1 cannabinoid receptors to reduce food intake in rats and mice. J Neurosci. 2010 May 26;30(21):7369-76. DOI:10.1523/JNEUROSCI.5455-09.2010
[2] Elaine F Toniolo, et al. Hemopressin, an inverse agonist of cannabinoid receptors, inhibits neuropathic pain in rats. Peptides. 2014 Jun;56:125-31. DOI:10.1016/j.peptides.2014.03.016
Hemopressin (human, bovine, porcine) Preparation Products And Raw materials
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