1H-Imidazol-4-ylmethylamine dihydrochloride
- Product Name
- 1H-Imidazol-4-ylmethylamine dihydrochloride
- CAS No.
- 72631-80-2
- Chemical Name
- 1H-Imidazol-4-ylmethylamine dihydrochloride
- Synonyms
- 1H-Imidazol-5-methanamine, 2HCl;1H-imidazol-3-ium-5-ylmethylazanium;iMidazole-4-MethanaMine dihydrochloride;4-(Aminomethyl)imidazole dihydrochloride;1H-Imidazole-4-methanamine dihydrochloride;1H-Imidazol-4-ylmethylamine dihydrochloride;(1H-IMidazol-4-yl)MethanaMine dihydrochloride;(1H-imidazol-5-yl)methanamine dihydrochloride;1-(1H-Imidazol-4-yl)methanamine dihydrochloride;1H-Imidazole-5-methanamine, hydrochloride (1:2)
- CBNumber
- CB52479979
- Molecular Formula
- C4H9Cl2N3
- Formula Weight
- 170
- MOL File
- 72631-80-2.mol
1H-Imidazol-4-ylmethylamine dihydrochloride Property
- Melting point:
- 246-247 °C
- storage temp.
- Inert atmosphere,Room Temperature
- form
- solid
- color
- Faint orange
- InChI
- InChI=1S/C4H7N3.2ClH/c5-1-4-2-6-3-7-4;;/h2-3H,1,5H2,(H,6,7);2*1H
- InChIKey
- SHZKSYVHYHSHGU-UHFFFAOYSA-N
- SMILES
- NCC1=CNC=N1.[H]Cl.[H]Cl
Safety
- HazardClass
- IRRITANT
- HS Code
- 2933299090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- I577588
- Product name
- (1H-Imidazol-4-yl)methanaminedihydrochloride
- Packaging
- 1g
- Price
- $45
- Updated
- 2021/12/16
- Product number
- I577588
- Product name
- (1H-Imidazol-4-yl)methanaminedihydrochloride
- Packaging
- 5g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- OR938259
- Product name
- 1-(1H-Imidazol-4-yl)methanaminedihydrochloride
- Purity
- 95%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- 3H30-5-AV
- Product name
- 1-(1H-Imidazol-4-yl)methanaminedihydrochloride
- Purity
- 97%
- Packaging
- 250mg
- Price
- $125
- Updated
- 2021/12/16
- Product number
- 027230
- Product name
- 1H-Imidazol-4-ylmethylamine dihydrochloride
- Packaging
- 500mg
- Price
- $138
- Updated
- 2021/12/16
1H-Imidazol-4-ylmethylamine dihydrochloride Chemical Properties,Usage,Production
Synthesis
3034-50-2
66247-84-5
General procedure for the synthesis of (1H-imidazol-4-yl)methanamine hydrochloride from 4-imidazolecarboxaldehyde: 12.0 g (124 mmol) of 4-formylimidazole with 750 mg of Nguyenne nickel catalyst was added to 1000 mL of ammonia in a methanolic solution and shaken for 30 min at 40 °C. Subsequently, the mixture was transferred to a Parr reactor and hydrogenated under hydrogen atmosphere at 5 bar pressure and 40 °C for 14 hours. Upon completion of the reaction, 750 mg of Nguyenay nickel catalyst was added additionally and the reaction conditions were adjusted to 50 °C and 5 bar hydrogen pressure and the hydrogenation was continued for 14 hours. At the end of the reaction, the mixture was filtered and concentrated under reduced pressure. Methanol, toluene and ethanol were sequentially added to the residue and each addition was concentrated under reduced pressure to completely remove the solvent. Subsequently, the residue was mixed with a methanolic solution of ether hydrochloric acid and concentrated again under reduced pressure. Finally, the residue was mixed with methanol and dichloromethane, respectively, and concentrated under reduced pressure after each addition. The product 21.2 g (quantitative yield) was obtained with an Rt value of 0.49 min (D). The molecular formula of the product was C4H7N3-2HCl (molecular weight: 170.04/97.12), and the (M+H)+ peak was detected by mass spectrometry with m/z=98.
References
[1] Patent: US2008/51578, 2008, A1. Location in patent: Page/Page column 34
1H-Imidazol-4-ylmethylamine dihydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1H-Imidazol-4-ylmethylamine dihydrochloride manufacturers
- Product
- 1H-Imidazol-4-ylmethylamine dihydrochloride 72631-80-2
- Price
- US $5.50/IU
- Min. Order
- 1ASSAYS
- Purity
- 98%min
- Supply Ability
- 1kg-100kg
- Release date
- 2020-01-10