1-(5-Bromo-2-chloropyridin-3-yl)ethanone

Product Name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
CAS No.: 886365-47-5
Chemical Name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
Synonyms: 2-chloro-5-bromo-3-acetylpyridine;1-(5-Bromo-2-chloro-3-pyridyl)ethanone;1-(5-Bromo-2-chloropyridin-3-yl)ethanone;Ethanone, 1-(5-bromo-2-chloro-3-pyridinyl)-;1-(5-bromo-2-chloropyridin-3-yl)ethan-1-one
CBNumber: CB52482302
Molecular Formula: C7H5BrClNO
Formula Weight: 234.48
MOL File: 886365-47-5.mol

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1-(5-Bromo-2-chloropyridin-3-yl)ethanone Property

Boiling point:: 282.5±40.0 °C(Predicted)
Density: 1.647±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
form: solid
pka: -4.03±0.10(Predicted)
Appearance: Light yellow to yellow Liquid
InChI: InChI=1S/C7H5BrClNO/c1-4(11)6-2-5(8)3-10-7(6)9/h2-3H,1H3
InChIKey: SQKOULMBBLJIKX-UHFFFAOYSA-N
SMILES: C(=O)(C1=CC(Br)=CN=C1Cl)C

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Safety

WGK Germany: WGK 3
HazardClass: IRRITANT
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral
Eye Irrit. 2
Skin Irrit. 2
STOT SE 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: ADE000790
Product name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
Purity: Aldrich
Packaging: 1g
Price: $817
Updated: 2025/07/31

TRC

Product number: B684693
Product name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
Packaging: 500mg
Price: $70
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-D-46
Product name: 1-(5-Bromo-2-chloropyridin-3-yl)ethan-1-one
Purity: 97.0%
Packaging: 250mg
Price: $115
Updated: 2021/12/16

AK Scientific

Product number: 1939AF
Product name: 1-(5-Bromo-2-chloropyridin-3-yl)ethanone
Packaging: 5g
Price: $237
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H56-D-46
Product name: 1-(5-Bromo-2-chloropyridin-3-yl)ethan-1-one
Purity: 97.0%
Packaging: 1g
Price: $290
Updated: 2021/12/16

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1-(5-Bromo-2-chloropyridin-3-yl)ethanone Chemical Properties,Usage,Production

Synthesis

1111638-41-5

886365-47-5

Procedure for the synthesis of 1-(5-bromo-2-chloropyridin-3-yl)ethanone (D-2-5): pyridine (13 g, 0.165 mol) was dissolved in dichloromethane (200 mL) at 0 °C, and chromium trioxide (CrO3, 8.25 g, 0.083 mol) and silica gel (20 mL) were added in batches with stirring. After addition, the reaction mixture was continued to be stirred for 10 minutes. Subsequently, 1-(5-bromo-2-chloropyridin-3-yl)ethanol (D-2-4, 6.5 g, 27.5 mmol) was added and the resulting mixture was stirred at room temperature overnight. The progress of the reaction was monitored by thin layer chromatography (TLC, unfolding agent: petroleum ether/ethyl acetate, 8:1) and it was confirmed that most of the raw material D-2-4 was converted. The reaction mixture was filtered and the filtrate was concentrated under reduced pressure to obtain the crude product D-2-5, which was further purified by column chromatography (silica gel, eluent: petroleum ether/ethyl acetate, 20:1) to obtain the pure D-2-5 (5 g, 77% yield) as a yellow oil.

References

[1] Patent: WO2009/16460, 2009, A2. Location in patent: Page/Page column 104-105

1-(5-Bromo-2-chloropyridin-3-yl)ethanone Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(5-Bromo-2-chloropyridin-3-yl)ethanone Suppliers

China 65 India 2 United States 7 Global 74

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886365-47-5, 1-(5-Bromo-2-chloropyridin-3-yl)ethanoneRelated Search:

1-(5-Bromo-2-chloropyridin-3-yl)ethanone

1-(5-bromo-2-chloropyridin-3-yl)ethan-1-one

1-(5-Bromo-2-chloro-3-pyridyl)ethanone

Ethanone, 1-(5-bromo-2-chloro-3-pyridinyl)-

2-chloro-5-bromo-3-acetylpyridine

886365-47-5