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Acetylthiocholine iodide

Product Name
Acetylthiocholine iodide
CAS No.
1866-15-5
Chemical Name
Acetylthiocholine iodide
Synonyms
Acetylthiocholine io;Acetylthiocholinjodid;acetylthiocholine iodie;Kamovsky-roots solution;ACETYLTHIOCHOLINE IODIDE;Iodine thioacetylcholine;Iodide thioacetylcholine;s-acetylthio-choliniodide;acetylthiocholinediiodide;acethylthiocholine iodide
CBNumber
CB5248470
Molecular Formula
C7H16INOS
Formula Weight
289.18
MOL File
1866-15-5.mol
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Acetylthiocholine iodide Property

Melting point:
205-210 °C(lit.)
Density 
1.4885 (estimate)
storage temp. 
2-8°C
solubility 
H2O: 100 mg/mL
form 
powder
color 
white
Water Solubility 
H2O: 100mg/mL
Sensitive 
Light Sensitive & Hygroscopic
BRN 
3916578
InChI
InChI=1S/C7H16NOS.HI/c1-7(9)10-6-5-8(2,3)4;/h5-6H2,1-4H3;1H/q+1;/p-1
InChIKey
NTBLZMAMTZXLBP-UHFFFAOYSA-M
SMILES
[N+](C)(C)(C)CCSC(=O)C.[I-]
CAS DataBase Reference
1866-15-5(CAS DataBase Reference)
EPA Substance Registry System
Ethanaminium, 2-(acetylthio)-N,N,N-trimethyl-, iodide (1866-15-5)
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Safety

Hazard Codes 
T,Xi
Risk Statements 
21-25-36/37/38
Safety Statements 
26-36
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
FZ9865000
F 
3-8-10
TSCA 
Yes
HazardClass 
6.1
PackingGroup 
III
HS Code 
29309099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
01480
Product name
Acetylthiocholine iodide
Purity
≥99.0% (AT)
Packaging
1g
Price
$50.4
Updated
2024/03/01
Sigma-Aldrich
Product number
01480
Product name
Acetylthiocholine iodide
Purity
≥99.0% (AT)
Packaging
5g
Price
$135
Updated
2024/03/01
TCI Chemical
Product number
A0116
Product name
Acetylthiocholine Iodide
Purity
>98.0%(T)
Packaging
1g
Price
$32
Updated
2024/03/01
TCI Chemical
Product number
A0116
Product name
Acetylthiocholine Iodide
Purity
>98.0%(T)
Packaging
5g
Price
$109
Updated
2024/03/01
Alfa Aesar
Product number
A16802
Product name
S-Acetylthiocholine iodide, 98%
Packaging
1g
Price
$29.5
Updated
2024/03/01
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Acetylthiocholine iodide Chemical Properties,Usage,Production

Description

Acetylthiocholine iodide, also known as ATCI, serves as both an acetylcholinesterase (AChE) substrate and a nicotinic acetylcholine receptor (AChR) agonist. ATCI itself is a colorless and odorless compound. It exhibits solubility in both water and ethanol. It is a synthetic compound extensively employed in laboratory experiments to measure the activity of AChE, a vital enzyme responsible for the breakdown of the neurotransmitter acetylcholine (ACh) in the central and peripheral nervous systems. Additionally, it enables the evaluation of drug effects on AChE activity and facilitates investigations into the impact of toxins on the nervous system. Acetylthiocholine iodide functions as an inhibitor of AChE. By binding to the enzyme′s active site, it prevents AChE from catalyzing the breakdown of ACh. Consequently, ACh accumulates in the synaptic cleft, leading to increased neuron excitability. This inhibition of AChE by ATCI ultimately results in a higher ACh concentration within the synaptic cleft, yielding a range of physiological effects. These effects encompass heightened muscle contraction, increased heart rate and blood pressure, elevated salivation, intensified bronchial secretions, and augmented gastrointestinal activity[1].

Chemical Properties

white crystalline powder

Uses

A nAChR agonist and substrate of acetylcholinesterase

Uses

Acetylthiocholine iodide has been used as a substrate in the preparation of acetylcholine esterase (AChE) assay working solution for AChE activity assay. It has also been used as a component in phosphate buffer (PB) for cholinesterase assay.

Uses

Substrate for the colorimetric determination of acetylcholinesterase activity.

Purification Methods

Recrystallise the iodide from propan-1-ol (or iso-PrOH, or EtOH/Et2O) until almost colourless and dry it in a vacuum desiccator over P2O5. Its solubility in H2O is 1% w/v. A 0.075M (21.7mg/mL) solution in 0.1M phosphate buffer pH 8.0 is stable for 10-15 days if kept refrigerated. Store it away from light. It is commercially available as a 1% solution in H2O. [Ellman et al. Biochemical Pharmacology 7, 88 1961, IR: Hansen Acta Chem Scand 13 151 1959, 11 537 1957, Clin Chim Acta 2 316 1957, Ivin Zh Obshch Khim 22 267 1952, Beilstein 4 III 726, 4 IV 1585.]

References

[1] Madalina-Petruta Bucur, Gabriel-Lucian Radu, Bogdan Bucur. “Critical evaluation of acetylthiocholine iodide and acetylthiocholine chloride as substrates for amperometric biosensors based on acetylcholinesterase.” Sensors 13 2 (2013): 1603–13.

Acetylthiocholine iodide Preparation Products And Raw materials

Raw materials

Acetic anhydride Acetone 2-DIMETHYLAMINOETHANETHIOL HYDROCHLORIDE 2-Dimethylaminoethanol Diethyl ether Ethyl acetate Hydrochloric acid Sodium bicarbonate Dichloromethane Sodium hydroxide Thionyl chloride Potassium thioacetate Iodomethane Thiourea

Preparation Products

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View Lastest Price from Acetylthiocholine iodide manufacturers

WUHAN FORTUNA CHEMICAL CO., LTD
Product
Acetylthiocholine iodide 1866-15-5
Price
US $0.00/G
Min. Order
500G
Purity
98%min
Supply Ability
30kg/month
Release date
2023-02-02
Hebei Yanxi Chemical Co., Ltd.
Product
ACETYLTHIOCHOLINE IODIDE 1866-15-5
Price
US $20.00-1.00/kg
Min. Order
1kg
Purity
0.99
Supply Ability
20 tons
Release date
2023-09-15
Hebei Chuanghai Biotechnology Co., Ltd
Product
ACETYLTHIOCHOLINE IODIDE 1866-15-5
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500000kg
Release date
2024-10-28

1866-15-5, Acetylthiocholine iodideRelated Search:

S-Butyrylthiocholine Iodide THIOCHOLINE IODIDE ETHYLTRIMETHYLAMMONIUM IODIDE ethyl ethanethioate Choline hydroxide Ammonium iodide CHOLINE IODIDE PROPIONYL-BETA-METHYL-THIOCHOLINE IODIDE BENZOYLTHIOCHOLINE IODIDE S-BUTYRYL-BETA-METHYLTHIOCHOLINE IODIDE ACETYLTHIOCHOLINE IODIDE ACETYL-BETA-(METHYLTHIO) CHOLINE IODIDE PROPIONYLTHIOCHOLINE IODIDE

  • Acetylthiocholinjodid
  • S-ACETYLTHIOCHOLINE IODIDE extrapure AR substrate for acetylcholinesterase
  • S-Acetylthiocholine iodide,98%
  • acetylthiocholinediiodide
  • Ethanaminium,2-(acetylthio)-N,N,N-trimethyl-,iodide
  • S-[2-(trimethyl-lambda<sup>5</sup>-azanyl)ethyl] ethanethioate hydroiodide
  • s-acetylthio-choliniodide
  • (2-MERCAPTOETHYL)TRIMETHYLAMMONIMUM IODIDE ACETATE
  • (2-MERCAPTOETHYL)TRIMETHYLAMMONIUM IODIDE ACETATE
  • 2-ACETOTHIOETHYLTRIMETHYLAMMONIUM IODIDE
  • [2-(ACETYLTHIO)ETHYL](TRIMETHYL)AMMONIUM IODIDE
  • 2-(THIOACETYLOXY)-N,N,N-TRIMETHYLETHANAMINIUM IODIDE
  • 2-(acetylsulfanyl)-N,N,N-trimethylethanaminium iodide
  • Acetylthiocholine iodide ,98%
  • Acetylthiocholine iodide,(2-Mercaptoethyl)trimethylammonium iodide acetate
  • Acetylthiocholine io
  • S-Acetylthiocholine iodide, 98% 1GR
  • S-Acetylthiocholine iodide, 98% 5GR
  • acetylthiocholine iodie
  • acethylthiocholine iodide
  • 2-acetylsulfanylethyl(trimethyl)azanium,iodide
  • INDICATOR PAPER PH 4,5-10 100 STRIPS
  • (2-mercaptoethyl)trimethyl-ammoniuiodideacetate
  • 2-(acetylthio)-n,n,n-trimethyl-ethanaminiuiodide
  • 2-(acetylthio)-n,n,n-trimethylethanaminiumiodide
  • S-ACETYLTHIOCHOLINE IODIDE
  • N-(2-MERCAPTOETHYL)TRIMETHYLAMMONIUM IODIDE ACETATE
  • THIOCHOLINE IODIDE ACETATE
  • Acetylthiocholine iodide≥ 98% (HPLC)
  • ACETYLTHIOCHOLINE IODIDE
  • AcetylthiocholineIodide&gt
  • S-Acetylthiocholine Iodide extrapure AR, 99%
  • 2-acetylsulfanylethyl(trimethyl)azanium
  • Iodine thioacetylcholine
  • 2-(Acetylthio)-N,N,N-trimethylethan-1-aminium iodide
  • Kamovsky-roots solution
  • Iodide thioacetylcholine
  • 1866-15-5
  • CH3COSCH2CH2NCH33I
  • C7H16SNOI
  • C7H16NOSI
  • C7H16INOS
  • Substrates by Enzyme
  • Acetylcholinesterase
  • Enzyme Substrates
  • Enzymes, Inhibitors, and Substrates
  • Ligand-Gated Ion Channels
  • Ion Channels
  • Nicotinic Acetylcholine Receptor Modulators
  • Cell Biology
  • Cell Signaling and Neuroscience
  • Ammonium Iodides (Quaternary)
  • Quaternary Ammonium Compounds
  • BioChemical
  • Biochemicals and Reagents
  • susbtrate
  • Substrates
  • Ammonium Iodides (Quaternary)