ChemicalBook > CAS DataBase List > 2-Chloro-1,5-naphthyridine

2-Chloro-1,5-naphthyridine

Product Name: 2-Chloro-1,5-naphthyridine
CAS No.: 7689-62-5
Chemical Name: 2-Chloro-1,5-naphthyridine
Synonyms: 2-Chloro-1,5-naphthyridine;1,5-Naphthyridine, 2-chloro-
CBNumber: CB52484715
Molecular Formula: C8H5ClN2
Formula Weight: 164.59
MOL File: 7689-62-5.mol

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2-Chloro-1,5-naphthyridine Property

Melting point:: 109-111℃
Boiling point:: 281℃
Density: 1.349
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
pka: 1.32±0.10(Predicted)
Appearance: White to off-white Solid
InChI: InChI=1S/C8H5ClN2/c9-8-4-3-6-7(11-8)2-1-5-10-6/h1-5H
InChIKey: JUYRQGHDOBBUEA-UHFFFAOYSA-N
SMILES: N1C2C(=NC=CC=2)C=CC=1Cl

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Safety

HS Code: 2933998090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H332Harmful if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P321Specific treatment (see … on this label).

P322Specific measures (see …on this label).

P330Rinse mouth.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P362Take off contaminated clothing and wash before reuse.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: C368783
Product name: 2-Chloro-1,5-naphthyridine
Packaging: 100mg
Price: $60
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141303
Product name: 2-Chloro-1,5-naphthyridine
Packaging: 100mg
Price: $84
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: HCH0363408
Product name: 2-CHLORO-1,5-NAPHTHYRIDINE
Purity: 95.00%
Packaging: 5MG
Price: $503.45
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC141303
Product name: 2-Chloro-1,5-naphthyridine
Packaging: 1g
Price: $506.25
Updated: 2021/12/16

AK Scientific

Product number: Z5113
Product name: 2-Chloro-1,5-naphthyridine
Packaging: 5g
Price: $586
Updated: 2021/12/16

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2-Chloro-1,5-naphthyridine Chemical Properties,Usage,Production

Synthesis

27305-48-2

7689-62-5

7689-63-6

(2) Synthesis of 2-chloro-1,5-diazanaphthalene. A 50 mL round bottom flask was charged with 1,5-diazanaphthalene N-oxide (98 mg, 1.355 mmol) and phosphorochloride (2 mL, 21.457 mmol). The reaction mixture was placed in an oil bath at 100 °C and the reaction was stirred for 8 hours. After completion of the reaction, the solvent was removed by rotary evaporator under reduced pressure. The residue was neutralized with saturated NaHCO3 solution (2 mL) and extracted with ethyl acetate (2 x 20 mL). The organic phases were combined, washed with saturated NaCl solution (2 mL), dried over anhydrous Na2SO4, filtered and concentrated under reduced pressure. The crude product was purified by silica gel column chromatography with 60% ethyl acetate/hexane as eluent to afford 2-chloro-1,5-diazanaphthalene (78 mg, 35% yield). Mass spectrum (ESI positive ion mode) m/z: calculated value C8H5ClN2 [M+H]+ 165.0, measured value 165.0. 1H NMR (300 MHz, CDCl3) δ ppm: 7.64 (d, J=8.77 Hz, 1H), 7.66-7.72 (m, J=4.38 Hz, 1H), 8.35 (t, J=8.77 Hz, 2H), 8.99 (dd, J=4.17,1.68Hz, 1H). 4-Chloro-1,5-diazaphthalene (86 mg, 39% yield) was also isolated. Mass spectrum (ESI positive ion mode) m/z: calculated value C8H5ClN2 [M+H]+ 165.0, measured value 165.0. 1H NMR (300 MHz, CDCl3) δ ppm: 7.75 (dd, J=8.55,4.17Hz, 1H), 7.79 (d, J=4.68Hz, 1H), 8.47 (dd, J=8.62,1.68Hz, 1H), 8.47 (dd, J=8.62,1.62Hz, 1.68Hz, 1H). 8.62,1.61Hz, 1H), 8.87 (d, J=4.68Hz, 1H), 9.11 (dd, J=4.09,1.61Hz, 1H).

References

[1] Journal of Medicinal Chemistry, 2011, vol. 54, # 13, p. 4735 - 4751
[2] Patent: WO2009/155121, 2009, A2. Location in patent: Page/Page column 104

2-Chloro-1,5-naphthyridine Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 2-Chloro-1,5-naphthyridine manufacturers

Nanjing jinheyou Trading Co., Ltd.

Product: 2-Chloro-1,5-naphthyridine 7689-62-5
Price: US $0.00/g
Min. Order: 1g
Purity: 95%min
Supply Ability: 20kg/month
Release date: 2019-12-30

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