PIK-75
- Product Name
- PIK-75
- CAS No.
- 372196-67-3
- Chemical Name
- PIK-75
- Synonyms
- CS-669;PIK 75;PIK75(HCl salt);PIK-75, free base;PIK-75 Hydrochloride;PI3-Kinase a Inhibitor VIII;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;(Z)-N'-((6-bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide;2-Methyl-5-nitro-1-benzenesulfonic acid 2-[(6-bromoimidazo[1,2-a]pyridin-3-yl)methylene]-1-methylhydrazide
- CBNumber
- CB52484861
- Molecular Formula
- C16H14BrN5O4S
- Formula Weight
- 452.28
- MOL File
- 372196-67-3.mol
PIK-75 Property
- Melting point:
- >203°C (dec.)
- Density
- 1.66±0.1 g/cm3(Predicted)
- storage temp.
- 2-8°C
- solubility
- Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly, Heated)
- form
- Solid
- pka
- 2.08±0.50(Predicted)
- color
- Light Yellow to Yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 462617
- Product name
- PIK-75
- Packaging
- 1mg
- Price
- $312
- Updated
- 2021/12/16
- Product number
- P437670
- Product name
- PIK-75
- Packaging
- 50mg
- Price
- $340
- Updated
- 2021/12/16
- Product number
- orb181090
- Product name
- PIK-75
- Purity
- >98%
- Packaging
- 250mg
- Price
- $912.9
- Updated
- 2021/12/16
- Product number
- 132629
- Product name
- (E)-N'-((6-Bromoimidazo[1,2-a]pyridin-3-yl)methylene)-N,2-dimethyl-5-nitrobenzenesulfonohydrazide
- Purity
- 97%
- Packaging
- 100mg
- Price
- $1080
- Updated
- 2021/12/16
- Product number
- SYN-1067-M005
- Product name
- PIK-75
- Purity
- ≥95%
- Packaging
- 5mg
- Price
- $70
- Updated
- 2021/12/16
PIK-75 Chemical Properties,Usage,Production
Uses
PIK-75 is a p110α inhibitor, isoform-specific mutants at Ser773, and also potently inhibits DNA-PK.
Definition
ChEBI: N-[(6-bromo-3-imidazo[1,2-a]pyridinyl)methylideneamino]-N,2-dimethyl-5-nitrobenzenesulfonamide is a sulfonamide.
Enzyme inhibitor
This novel phosphoinositide-3 kinase p110α inhibitor (F.Wt. = 488.74; CAS 372196-67-3; Solubility (25°C): 98 mg/mL DMSO, <1 mg/mL Water), also known as (E)-N'-((6-bromoH-imidazo[1,2-a]pyridin-3-yl)methylene)-N,2- dimethyl-5-nitrobenzenesulfonohydrazide-HCl, competes with respect to a substrate (phosphatidylinositol, PI), unlike most other PI3K inhibitors, which bind at or near the ATP site. PIK-75 exhibits impressive isoform selectivity, with an IC50 value of 5.8 nM for p110α, while the corresponding IC50 values are 1300 nM, 76 nM and 510 nM for p110β, p110γ, and p110δ, respectively.
PIK-75 Preparation Products And Raw materials
Raw materials
Preparation Products
PIK-75 Suppliers
- Tel
- --
- Fax
- --
- info@activate-scientific.com
- Country
- Germany
- ProdList
- 2856
- Advantage
- 61