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(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid

Product Name
(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
CAS No.
167837-43-6
Chemical Name
(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid
Synonyms
-3-(6-Aminopyridin-3-yl);3-(6-Amino-pyridin-3-yl)-acrylic acid;(E)-3-(6-AMino-3-pyridyl)acrylic Acid;(E)-3-(6-AMinopyridin-3-yl)acrylic acid;3-(6-amino-3-pyridinyl)-2-propenoic acid; (2E)-3-(6-Amino-3-pyridinyl)acrylic acid;(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid;(2E)-3-(6-aMinopyridin-3-yl)prop-2-enoic acid;2-Propenoic acid,3-(6-amino-3-pyridinyl)-, (2E)-
CBNumber
CB52485035
Molecular Formula
C8H8N2O2
Formula Weight
164.16
MOL File
167837-43-6.mol
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(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Property

Boiling point:
394.9±32.0 °C(Predicted)
Density 
1.361
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
pka
3.07±0.10(Predicted)
Appearance
Yellow to brown Solid
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
A636618
Product name
(E)-3-(6-Amino-3-pyridyl)acrylicAcid
Packaging
50mg
Price
$45
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151600
Product name
(2e)-3-(6-Amino-3-pyridinyl)-2-propenoicacid
Packaging
2mg
Price
$59
Updated
2021/12/16
AK Scientific
Product number
W3656
Product name
(E)-3-(6-Aminopyridin-3-yl)acrylicacid
Packaging
250mg
Price
$82
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151600
Product name
(2e)-3-(6-Amino-3-pyridinyl)-2-propenoicacid
Packaging
5mg
Price
$117
Updated
2021/12/16
Biosynth Carbosynth
Product number
FA151600
Product name
(2e)-3-(6-Amino-3-pyridinyl)-2-propenoicacid
Packaging
10mg
Price
$203
Updated
2021/12/16
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(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Chemical Properties,Usage,Production

Synthesis

1072-97-5

79-10-7

167837-43-6

(a) Synthesis of (E)-3-(6-aminopyridin-3-yl)acrylic acid: To an aqueous (600mL) solution of 2-amino-5-bromopyridine (25.92g, 0.15mol) was slowly added an aqueous solution of acrylic acid (23mL, 0.33mol) and sodium carbonate (Na2CO3, 55.64g, 0.53mol). Subsequently, palladium dichloride (PdCl2, 0.53 g, 0.003 mol) was added as a catalyst and the reaction mixture was heated to reflux. After 24 hours of reaction, it was cooled to room temperature and filtered to remove insoluble material. The filtrate was adjusted to pH 6 with aqueous hydrochloric acid, and water (0.5 L) was added to improve mixing, and stirring was continued for 1 hour. The pH was again adjusted to 6 and the precipitated solid product was collected by diafiltration. The solid was washed sequentially with water (2 × 0.5 L), cold anhydrous ethanol (EtOH, 100 mL) and ether (Et2O, 2 × 250 mL). Finally, the target product (E)-3-(6-amino-3-pyridinyl)acrylic acid (15.38 g, 62% yield) was obtained as a brown solid by drying at high temperature under high vacuum. The product was confirmed by 1H NMR (300 MHz, DMSO-d6) and mass spectrometry (MS): 1H NMR δ 8.11 (d, J = 2.0 Hz, 1H), 7.75 (dd, J = 8.7,2.0 Hz, 1H), 7.43 (d, J = 15.8 Hz, 1H), 6.53 (s, 2H), 6.45 (d, J = 8.7 Hz. 1H), 6.22 (d, J = 15.8 Hz, 1H); MS (ES) m/e 165 (M + H)+.

References

[1] Journal of Medicinal Chemistry, 2002, vol. 45, # 15, p. 3246 - 3256
[2] Patent: EP1226138, 2004, B1
[3] RSC Advances, 2018, vol. 8, # 42, p. 23698 - 23710

(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Preparation Products And Raw materials

Raw materials

Preparation Products

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(2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid Suppliers

China 58 India 1 United Kingdom 3 United States 6 Global 68
Accela ChemBio Inc.
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+1(858) 699-3322
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+1(858) 876-1948
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Accela ChemBio Inc.
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+1-858-6993322
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APAC Pharmaceutical, LLC
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Combi-Blocks Inc.
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View Lastest Price from (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acid manufacturers

Career Henan Chemical Co
Product
(2E)-3-(6-Amino-3-pyridinyl)acrylic acid 167837-43-6
Price
US $1.00/KG
Min. Order
1KG
Purity
Min98% HPLC
Supply Ability
g/kg/ton
Release date
2020-01-29

167837-43-6, (2E)-3-(6-Amino-3-pyridinyl)-2-propenoic acidRelated Search:


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  • 3-(6-Amino-pyridin-3-yl)-acrylic acid
  • (2E)-3-(6-aMinopyridin-3-yl)prop-2-enoic acid
  • (E)-3-(6-AMinopyridin-3-yl)acrylic acid
  • (E)-3-(6-AMino-3-pyridyl)acrylic Acid
  • -3-(6-Aminopyridin-3-yl)
  • (2E)-3-(6-Amino-3-pyridinyl)acrylic acid
  • 3-(6-amino-3-pyridinyl)-2-propenoic acid
  • 2-Propenoic acid,3-(6-amino-3-pyridinyl)-, (2E)-
  • 167837-43-6