Methyl 2-methylindazole-6-carboxylate

Product Name: Methyl 2-methylindazole-6-carboxylate
CAS No.: 1071433-01-6
Chemical Name: Methyl 2-methylindazole-6-carboxylate
Synonyms: -2H-indazoL;Methyl 2-methylindazole-6-carboxylate;Methyl 2-Methyl-2H-indazol-6-carboxylate;6-(Methoxycarbonyl)-2-methyl-2H-indazole;methyl 2-methyl-2H-indazole-6-carboxylate;2-Methyl-2H-indazole-6-carboxylic acid methyl ester;2H-Indazole-6-carboxylic acid, 2-methyl-, methyl ester;2-Methyl-2H-indazole-6-carboxylic acid methyl ester
CBNumber: CB52485606
Molecular Formula: C10H10N2O2
Formula Weight: 190.2
MOL File: 1071433-01-6.mol

More

Less

Methyl 2-methylindazole-6-carboxylate Property

Boiling point:: 338.9±15.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,Room Temperature
form: solid
pka: -0.39±0.30(Predicted)
Appearance: Off-white to light yellow Solid

More

Less

Safety

WGK Germany: 3
HS Code: 2933998090

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SYX00170
Product name: 2-Methyl-2H-indazole-6-carboxylic acid methyl ester
Purity: Aldrich
Packaging: 1g
Price: $639
Updated: 2025/07/31

TRC

Product number: M321240
Product name: 2-Methyl-2H-indazole-6-carboxylic acid methyl ester
Packaging: 5g
Price: $1260
Updated: 2021/12/16

Apolloscientific

Product number: OR30724
Product name: Methyl 2-methyl-2H-indazole-6-carboxylate
Packaging: 1g
Price: $71
Updated: 2021/12/16

SynQuest Laboratories

Product number: 4H23-1-Q9
Product name: Methyl 2-methyl-2H-indazole-6-carboxylate
Packaging: 1g
Price: $84
Updated: 2021/12/16

Apolloscientific

Product number: OR30724
Product name: Methyl 2-methyl-2H-indazole-6-carboxylate
Packaging: 5g
Price: $254
Updated: 2021/12/16

More

Less

Methyl 2-methylindazole-6-carboxylate Chemical Properties,Usage,Production

Uses

2-Methyl-2H-indazole-6-carboxylic Acid Methyl Ester is a useful synthetic intermediate. It is an analog of Indazole-3-carboxylic Acid Methyl Ester (I505250) which has potential as application of N-benzoylindazole derivatives and analogues as inhibitors of human neutrophil elastase. Indazole-3-carboxylic Acid Methyl Ester (I505250) is also used in the preparation of indazole-pyridine based protain kinase/Akt inhibitors.

Synthesis

170487-40-8

74-88-4

1007219-73-9

1071433-01-6

Sodium hydride (60% dispersed in mineral oil, 154 mg, 3.85 mmol) was added batchwise to an anhydrous tetrahydrofuran solution of methyl 1H-indazole-6-carboxylate (566 mg, 3.21 mmol) under cooling conditions in an ice bath. The reaction mixture was stirred at room temperature for 30 min. Subsequently, iodomethane (547 mg, 3.85 mmol) was slowly added dropwise and the reaction was continued with stirring at room temperature overnight. Upon completion of the reaction, the mixture was cooled to 0 °C, the reaction was quenched by careful addition of water and extracted with ethyl acetate. The organic phases were combined, dried over anhydrous sodium sulfate and concentrated under reduced pressure. Purification by silica gel column chromatography afforded methyl 1-methyl-1H-indazole-6-carboxylate (130 mg) and methyl 2-methyl-2H-indazole-6-carboxylate (230 mg) in 59% overall yield. The structures of the products were confirmed by 1H NMR: 1-methyl-1H-indazole-6-carboxylic acid methyl ester: 1H NMR (400 MHz, CDCl3) δ 3.97 (3H, s), 4.14 (3H, s), 7.74-7.82 (2H, m), 8.02 (1H, s), 8.17 (1H, d, J = 0.8 Hz). 2-methyl-2H-indazole- 6-carboxylic acid methyl ester: 1H NMR (400 MHz, CDCl3) δ 3.94 (3H, s), 4.25 (3H, s), 7.65-7.72 (2H, m), 7.92 (1H, s), 8.47 (1H, d, J = 1.2 Hz). Mass spectral analysis: [M + H]+ m/z 191.0815 (calculated value C10H11N2O2, 191.0816).

References

[1] Patent: WO2014/89364, 2014, A1. Location in patent: Paragraph 00477; 00478

Methyl 2-methylindazole-6-carboxylate Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

Methyl 2-methylindazole-6-carboxylate Suppliers

China 45 India 2 United Kingdom 2 United States 8 Global 57

Synthonix Inc

Tel: --
Fax: --
Email: info@synthonix.com
Country: United States
ProdList: 6872
Advantage: 58

NE Scientific

Tel: --
Fax: --
Country: United States
ProdList: 5030
Advantage: 55

Combi-Blocks Inc.

Tel: --
Fax: --
Email: sales@combi-blocks.com
Country: United States
ProdList: 6618
Advantage: 69

SynQuest Laboratories, Inc.

Tel: --
Fax: --
Email: info@synquestlabs.com
Country: United States
ProdList: 6871
Advantage: 62

Riedel-de Haen AG

Tel: --
Fax: --
Country: United States
ProdList: 6773
Advantage: 87

Frontier Scientific, Inc.

Tel: --
Fax: --
Email: sales@frontiersci.com
Country: United States
ProdList: 6222
Advantage: 86

Matrix Scientific

Tel: --
Fax: --
Email: sales@matrixscientific.com
Country: United States
ProdList: 6632
Advantage: 80

American Custom Chemicals Corporation

Tel: --
Fax: --
Email: sales@acccorporation.com
Country: United States
ProdList: 6820
Advantage: 51

1071433-01-6, Methyl 2-methylindazole-6-carboxylateRelated Search:

6-(Methoxycarbonyl)-2-methyl-2H-indazole

Methyl 2-Methyl-2H-indazol-6-carboxylate

2-Methyl-2H-indazole-6-carboxylic acid methyl ester

Methyl 2-methylindazole-6-carboxylate

methyl 2-methyl-2H-indazole-6-carboxylate

2H-Indazole-6-carboxylic acid, 2-methyl-, methyl ester

-2H-indazoL

2-Methyl-2<i>H</i>-indazole-6-carboxylic acid methyl ester

1071433-01-6