2-Hydroxy Atorvastatin Lactone-d5

Product Name: 2-Hydroxy Atorvastatin Lactone-d5
CAS No.: 265989-50-2
Chemical Name: 2-Hydroxy Atorvastatin Lactone-d5
Synonyms: 2-Hydroxy Atorvastatin Lactone-d5;[2H5]-2-Hydroxy Atorvastatin Lactone;5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide;5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide-d5;1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]- (9CI)
CBNumber: CB52487105
Molecular Formula: C33H33FN2O5
Formula Weight: 556.6239232
MOL File: 265989-50-2.mol

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2-Hydroxy Atorvastatin Lactone-d5 Property

Melting point:: 103-107°C
storage temp.: Hygroscopic, -20°C Freezer, Under Inert Atmosphere
solubility: Chloroform (Slightly), Methanol (Slightly)
form: Solid
color: Pale Yellow to Beige
Stability:: Hygroscopic

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: H828957
Product name: 2-HydroxyAtorvastatinLactone-d5
Packaging: 1mg
Price: $305
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0007281
Product name: ORTHO-HYDROXY ATORVASTATIN-D5-LACTONE
Purity: 95.00%
Packaging: 1MG
Price: $866.25
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: RDL0007281
Product name: ORTHO-HYDROXY ATORVASTATIN-D5-LACTONE
Purity: 95.00%
Packaging: 10MG
Price: $2887.5
Updated: 2021/12/16

aablocks

Product number: AA002TQO
Product name: 1H-Pyrrole-3-carboxamide,5-(4-fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-(9CI)
Packaging: 1mg
Price: $538
Updated: 2021/12/16

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2-Hydroxy Atorvastatin Lactone-d5 Chemical Properties,Usage,Production

Chemical Properties

Yellow Solid

Uses

Ortho-hydroxy atorvastatin lactone-d5 is deuterium labeled 2-Hydroxy atorvastatin lactone. 2-Hydroxy atorvastatin lactone is a metabolite of Atorvastatin. Atorvastatin is an orally active HMG-CoA reductase inhibitor, has the ability to effectively decrease blood lipids[1][2].

References

[1] Russak EM, et al. Impact of Deuterium Substitution on the Pharmacokinetics of Pharmaceuticals. Ann Pharmacother. 2019;53(2):211-216. DOI:10.1177/1060028018797110
[2] Guo CX, et al. Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices. Xenobiotica. 2012;42(8):784‐790. DOI:10.3109/00498254.2012.661100
[3] Turner NA, et al. Comparison of the efficacies of five different statins on inhibition of human saphenous vein smooth muscle cell proliferation and invasion. J Cardiovasc Pharmacol. 2007 Oct;50(4):458-61. DOI:10.1097/FJC.0b013e318123767f

2-Hydroxy Atorvastatin Lactone-d5 Preparation Products And Raw materials

Raw materials

Preparation Products

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2-Hydroxy Atorvastatin Lactone-d5 Suppliers

Canada 1 China 21 India 3 United States 2 Global 27

J & K SCIENTIFIC LTD.

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265989-50-2, 2-Hydroxy Atorvastatin Lactone-d5Related Search:

Ortho-Hydroxy atorvastatin calcium salt di(2-Hydroxy Atorvastatin) CalciuM Salt O-HYDROXY ATORVASTATIN LACTONE Atorvastatin Isopropyl Ester ATV-FX1 sodiuM salt Dihydroxy Diketo Atorvastatin IMpurity 5-Oxo Atorvastatin tert-Butyl Ester Atorvastatin Impurity 46 Atorvastatin Impurity 38 Atorvastatin 3-Oxo Atorvastatin tert-Butyl Ester Atorvastatin Impurity 31 Atorvastatin Impurity 15 Difluoro Atorvastatin Acetonide tert-Butyl Ester 2-[1,2-Bis-(4-fluoro-phenyl)-2-oxo-ethyl]-4-methyl-3-oxo-pentanoic acid phenylamide 2,3-Dehydroxy Atorvastatin Sodium Salt Atorvastatin Dehydro Lactone Atorvastatin Impurity 20

5-(4-Fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-Methylethyl)-4-phenyl-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]-1H-pyrrole-3-carboxaMide-d5

2-Hydroxy Atorvastatin Lactone-d5

5-(4-fluorophenyl)-1-[2-[(2R,4R)-4-hydroxy-6-oxooxan-2-yl]ethyl]-N-(2-hydroxyphenyl)-4-(2,3,4,5,6-pentadeuteriophenyl)-2-propan-2-ylpyrrole-3-carboxamide

[2H5]-2-Hydroxy Atorvastatin Lactone

1H-Pyrrole-3-carboxamide, 5-(4-fluorophenyl)-N-(2-hydroxyphenyl)-2-(1-methylethyl)-4-(phenyl-d5)-1-[2-[(2R,4R)-tetrahydro-4-hydroxy-6-oxo-2H-pyran-2-yl]ethyl]- (9CI)

265989-50-2

Isotope Labelled Compounds

Metabolites

Isotope Labelled Compounds, Metabolites