ChemicalBook > CAS DataBase List > methyl 2,6-dichloro-4-methylnicotinate

methyl 2,6-dichloro-4-methylnicotinate

Product Name
methyl 2,6-dichloro-4-methylnicotinate
CAS No.
1013648-04-8
Chemical Name
methyl 2,6-dichloro-4-methylnicotinate
Synonyms
methyl 2,6-dichloro-4-methylnicotinate;2,6-Dichloro-4-methylnicotinic acid methyl ester;methyl 2,6-dichloro-4-methyl-pyridine-3-carboxylate;2,6-Dichloro-4-methylpyridine-3-carboxylic acid methyl ester;3-Pyridinecarboxylic acid, 2,6-dichloro-4-methyl-, methyl ester
CBNumber
CB52489811
Molecular Formula
C8H7Cl2NO2
Formula Weight
220.05
MOL File
1013648-04-8.mol
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methyl 2,6-dichloro-4-methylnicotinate Property

Boiling point:
292℃
Density 
1.369
Flash point:
130℃
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-3.75±0.10(Predicted)
Appearance
Light brown to yellow Solid
InChI
InChI=1S/C8H7Cl2NO2/c1-4-3-5(9)11-7(10)6(4)8(12)13-2/h3H,1-2H3
InChIKey
QOTFUYQFPHLJTM-UHFFFAOYSA-N
SMILES
C1(Cl)=NC(Cl)=CC(C)=C1C(OC)=O
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0061273
Product name
Methyl2,6-dichloro-4-methylnicotinate
Packaging
5g
Price
$440
Updated
2021/12/16
ChemScene
Product number
CS-0061273
Product name
Methyl2,6-dichloro-4-methylnicotinate
Packaging
250mg
Price
$59
Updated
2021/12/16
ChemScene
Product number
CS-0061273
Product name
Methyl2,6-dichloro-4-methylnicotinate
Packaging
1g
Price
$142
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
HCH0050088
Product name
METHYL 2,6-DICHLORO-4-METHYLNICOTINATE
Purity
95.00%
Packaging
1G
Price
$945.95
Updated
2021/12/16
AK Scientific
Product number
0371AA
Product name
Methyl2,6-dichloro-4-methylnicotinate
Packaging
10g
Price
$1130
Updated
2021/12/16
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methyl 2,6-dichloro-4-methylnicotinate Chemical Properties,Usage,Production

Synthesis

62774-90-7

74-88-4

1013648-04-8

(A) Synthesis of methyl 2,6-dichloro-4-methylnicotinate: 8.05 g (39.1 mmol) of 2,6-dichloro-4-methylnicotinate [Lamm, G. Ger. Offen. (1977), DE 2538950] was dissolved in 100 mL of DMF, followed by the addition of 8.10 g (58.6 mmol) of potassium carbonate. Under stirring conditions, 12.16 mL (27.7 g, 195.4 mmol) of iodomethane was added slowly and dropwise. The reaction mixture was stirred continuously for 6 hours at room temperature. After completion of the reaction, the mixture was poured into crushed ice and extracted twice with EtOAc. The organic phases were combined, washed with water, dried over magnesium sulfate, filtered and the solvent evaporated to give 8.47 g (99% yield) of methyl 2,6-dichloro-4-methylnicotinate as a light yellow solid. Mass spectral data: 219.0 (M+, containing 2Cl).

References

[1] Patent: US2009/48238, 2009, A1. Location in patent: Page/Page column 22
[2] Patent: US2009/318467, 2009, A1. Location in patent: Page/Page column 23
[3] Patent: US2012/101079, 2012, A1. Location in patent: Page/Page column 74
[4] Patent: WO2012/52167, 2012, A1. Location in patent: Page/Page column 171-172
[5] Patent: US2017/183342, 2017, A1. Location in patent: Paragraph 0231

methyl 2,6-dichloro-4-methylnicotinate Preparation Products And Raw materials

Raw materials

Preparation Products

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1013648-04-8, methyl 2,6-dichloro-4-methylnicotinateRelated Search:

Nicotinic acid

  • methyl 2,6-dichloro-4-methylnicotinate
  • 2,6-Dichloro-4-methylnicotinic acid methyl ester
  • 2,6-Dichloro-4-methylpyridine-3-carboxylic acid methyl ester
  • 3-Pyridinecarboxylic acid, 2,6-dichloro-4-methyl-, methyl ester
  • methyl 2,6-dichloro-4-methyl-pyridine-3-carboxylate
  • 1013648-04-8