(R)-3-Hydroxypyrrolidin-2-one
- Product Name
- (R)-3-Hydroxypyrrolidin-2-one
- CAS No.
- 77510-50-0
- Chemical Name
- (R)-3-Hydroxypyrrolidin-2-one
- Synonyms
- (R)-3-Hydroxy-2-pyrrolidone;(R)-3-Hydroxypyrrolidin-2-one;(R)-4-hydroxy-2-oxopyrrolidine;(R)-3-Hydroxy-pyrrolidine-2-one;2-Pyrrolidinone, 3-hydroxy-, (3R)-
- CBNumber
- CB52490093
- Molecular Formula
- C4H7NO2
- Formula Weight
- 101.1
- MOL File
- 77510-50-0.mol
(R)-3-Hydroxypyrrolidin-2-one Property
- Melting point:
- 100-103℃
- Boiling point:
- 364℃
- Density
- 1.292
- Flash point:
- 174℃
- storage temp.
- 2-8°C
- pka
- 12.82±0.20(Predicted)
- Appearance
- Off-white to yellow Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- H956220
- Product name
- (R)-3-Hydroxypyrrolidin-2-one
- Packaging
- 50mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- H956220
- Product name
- (R)-3-Hydroxypyrrolidin-2-one
- Packaging
- 100mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- H956220
- Product name
- (R)-3-Hydroxypyrrolidin-2-one
- Packaging
- 500mg
- Price
- $285
- Updated
- 2021/12/16
- Product number
- CS-W018663
- Product name
- (R)-3-Hydroxypyrrolidin-2-one
- Purity
- >97.0%
- Packaging
- 10g
- Price
- $819
- Updated
- 2021/12/16
- Product number
- AS38717
- Product name
- (R)-3-Hydroxypyrrolidin-2-one
- Purity
- 95% ee
- Packaging
- 1g
- Price
- $342
- Updated
- 2021/12/16
(R)-3-Hydroxypyrrolidin-2-one Chemical Properties,Usage,Production
Synthesis
34368-52-0
77510-50-0
General procedure for the synthesis of (R)-3-hydroxypyrrolidinone from (S)-3-hydroxy-2-pyrrolidinone: To a mixture of (S)-3-hydroxy-2-pyrrolidinone (5.100 g, 50.4 mmol, 1.0 eq.) and 4-nitrobenzoic acid (9.273 g, 55.5 mmol. 1.1 eq.) to a mixture of triphenylphosphine (26.461 g, 100.9 mmol, 2.0 eq.). Subsequently, dipropyl azodicarboxylate (14.898 mL, 75.7 mmol, 1.5 equiv) was added dropwise under external cooling in a cold water bath. The reaction mixture was stirred overnight at room temperature. Upon completion of the reaction, the mixture was concentrated in vacuum to give the crude product. Methanol (130 mL) and potassium carbonate (0.38 g) were added to the crude product and stirred at room temperature for 8 hours. The reaction mixture was diluted with dichloromethane and filtered through diatomaceous earth. The diatomaceous earth bed was washed with a 1% dichloromethane solution of methanol. The filtrates were combined and concentrated to dryness. The residue was partitioned between ethyl acetate and dilute hydrochloric acid aqueous solution (20 mL, 9:1) and stirred for 15 minutes. The organic and aqueous layers were separated and the aqueous layer was washed three times with ethyl acetate. The aqueous layer was concentrated to dryness to give a solid residue. The crude product was washed with a dichloromethane solution (3 x 50 mL) of 1-2% methanol, dried over anhydrous sodium sulfate, filtered and concentrated to give a brown oil (3.3 g, 60% yield). The structure of the product was confirmed by 1H NMR (300 MHz, CDCl3): δ 4.32-4.27 (t, 1H, J = 8.5 Hz), 3.36-3.19 (m, 2H), 2.48-2.40 (m, 1H), 2.07-1.93 (m, 1H), 1.16-1.14 (d, 1H, J = 6.3 Hz).
References
[1] Patent: US2015/284362, 2015, A1. Location in patent: Paragraph 0386
[2] Patent: WO2011/13141, 2011, A2. Location in patent: Page/Page column 50
(R)-3-Hydroxypyrrolidin-2-one Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (R)-3-Hydroxypyrrolidin-2-one manufacturers
- Product
- (R)-3-Hydroxypyrrolidin-2-one 77510-50-0
- Price
- US $1.00/KG
- Min. Order
- 100g
- Purity
- 98%
- Supply Ability
- 200KG
- Release date
- 2019-12-17