Nsc21187
- Product Name
- Nsc21187
- CAS No.
- 87932-49-8
- Chemical Name
- Nsc21187
- Synonyms
- Nsc21187;3-chloro-4,5-dihydroxybenzoic acid;Benzoic acid, 3-chloro-4,5-dihydroxy-
- CBNumber
- CB52492279
- Molecular Formula
- C7H5ClO4
- Formula Weight
- 188.57
- MOL File
- 87932-49-8.mol
Nsc21187 Property
- Boiling point:
- 391.7±42.0 °C(Predicted)
- Density
- 1.702±0.06 g/cm3(Predicted)
- storage temp.
- Sealed in dry,Room Temperature
- pka
- 4.08±0.10(Predicted)
- Appearance
- White to off-white Solid
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 2705AQ
- Product name
- 3-CHLORO-4,5-DIHYDROXYBENZOICACID
- Packaging
- 500mg
- Price
- $390.8
- Updated
- 2021/12/16
- Product number
- CD12020141
- Product name
- 3-Chloro-4,5-dihydroxybenzoicacid
- Purity
- 95+%
- Packaging
- 5g
- Price
- $792
- Updated
- 2021/12/16
- Product number
- CM132886
- Product name
- 3-chloro-4,5-dihydroxybenzoicacid
- Purity
- 95%
- Packaging
- 5g
- Price
- $982
- Updated
- 2021/12/16
- Product number
- 87932498
- Product name
- 3-Chloro-4,5-dihydroxybenzoicacid
- Packaging
- 5g
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- CD12020141
- Product name
- 3-Chloro-4,5-dihydroxybenzoicacid
- Purity
- 95+%
- Packaging
- 10g
- Price
- $1485
- Updated
- 2021/12/16
Nsc21187 Chemical Properties,Usage,Production
Synthesis
62936-23-6
87932-49-8
General procedure for the synthesis of 3-chloro-4,5-dihydroxybenzoic acid from 3-chloro-4-hydroxy-5-methoxybenzoic acid: Step (i): tribromoborane (7.86 mL, 82 mmol) was added dropwise to a stirred solution of 3-chloro-4-hydroxy-5-methoxybenzoic acid (6.61 g, 32.6 mmol) in dichloromethane (50 mL) under nitrogen protection. The reaction mixture was continued to be stirred at 0 °C for 2 h and subsequently poured in batches into ice/brine (250 mL). The aqueous phase was extracted with ethyl acetate (2 x 150 mL) and the combined organic phases were dried over magnesium sulfate and filtered. The solvent was removed by concentration under reduced pressure to give 3-chloro-4,5-dihydroxybenzoic acid (5.11 g, 79% yield). Mass spectrum (electrospray ionization, negative mode) m/z 187 [M-H]? ; 1H NMR (400 MHz, DMSO-d?) δ: 12.69 (1H, broad single peak), 10.14 (2H, broad single peak), 7.35 (1H, double peak), 7.32 (1H, double peak).
References
[1] Patent: WO2011/27106, 2011, A1. Location in patent: Page/Page column 106-107
[2] Patent: US2012/149737, 2012, A1. Location in patent: Page/Page column 58
[3] Bioorganic and Medicinal Chemistry, 2018, vol. 26, # 4, p. 798 - 814
Nsc21187 Preparation Products And Raw materials
Raw materials
Preparation Products
Nsc21187 Suppliers
- Tel
- --
- Fax
- --
- sales@ajchem.in
- Country
- India
- ProdList
- 6100
- Advantage
- 58