Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride

Product Name: Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
CAS No.: 5897-18-7
Chemical Name: Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride
Synonyms: Cyclizine 2HCl;Marzine hydrochloride;Cyclizine 2hydrochloride;Cyclizine dihydrochloride;Piperazine, 1-benzhydryl-4-methyl-, dihydrochloride;1-Diphenylmethyl-4-methylpiperazine dihydrochloride;Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride;Piperazine, 1-(diphenylmethyl)-4-methyl-, hydrochloride (1:2);Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride USP/EP/BP
CBNumber: CB52497865
Molecular Formula: C18H24Cl2N2
Formula Weight: 339.30256
MOL File: 5897-18-7.mol

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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Property

storage temp.: Inert atmosphere,Store in freezer, under -20°C
solubility: Soluble in DMSO > 10 mM
form: Powder

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 2344AH
Product name: Cyclizine2HCl
Packaging: 25mg
Price: $129
Updated: 2021/12/16

ApexBio Technology

Product number: B1548
Product name: Cyclizine2HCl
Packaging: 50mg
Price: $146
Updated: 2021/12/16

CSNpharm

Product number: CSN22573
Product name: Cyclizine2HCl
Packaging: 10mg
Price: $36
Updated: 2021/12/16

CSNpharm

Product number: CSN22573
Product name: Cyclizine2HCl
Packaging: 50mg
Price: $61
Updated: 2021/12/16

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Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Chemical Properties,Usage,Production

Biological Activity

Cyclizine 2HCl is a piperazine derivative with Histamine H1 receptor antagonist activity.

in vitro

Cyclizine is a piperazine histamine H1 receptor antagonist and has anticholinergic and antiemetic properties. It increases lower esophageal sphincter tone and reduces the sensitivity of tortuous organs.

in vivo

Cyclizine is metabolized to its N-desmethyl derivative, Norcyclizine, which has little antihistamine (H1) activity compared to Cyclizine. After oral administration of Cyclizine, the effect will be produced within 30 minutes, and the maximum effect will be achieved within 1-2 hours, which can last for 4-6 hours. Cyclizine administered orally at a dose of 50 mg alone in healthy adult volunteers produced peak plasma concentrations of approximately 70 ng/mL two hours after dosing. The plasma elimination half-life is about 20 hours.

target

Target	Value
Histamine H1 receptor

Piperazine, 1-diphenylmethyl-4-methyl-, dihydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

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