6-Bromo-5-fluoro-2-pyridinecarboxylic acid
- Product Name
- 6-Bromo-5-fluoro-2-pyridinecarboxylic acid
- CAS No.
- 1052714-46-1
- Chemical Name
- 6-Bromo-5-fluoro-2-pyridinecarboxylic acid
- Synonyms
- 6-BroMo-5-fluoropicolinic acid;6-Bromo-5-fluoro-2-pyridinecarboxylic acid;2-Pyridinecarboxylic acid, 6-broMo-5-fluoro-;6-Bromo-5-fluoro-2-pyridinecarboxylic acid (6-?bromo-?5-?fluoropicolinic acid)
- CBNumber
- CB52500606
- Molecular Formula
- C6H3BrFNO2
- Formula Weight
- 220
- MOL File
- 1052714-46-1.mol
6-Bromo-5-fluoro-2-pyridinecarboxylic acid Property
- Boiling point:
- 331.3±42.0 °C(Predicted)
- Density
- 1.903
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- solid
- pka
- 3.19±0.10(Predicted)
- Appearance
- White to off-white Solid
- InChI
- 1S/C6H3BrFNO2/c7-5-3(8)1-2-4(9-5)6(10)11/h1-2H,(H,10,11)
- InChIKey
- UVDJYBXHNFJTME-UHFFFAOYSA-N
- SMILES
- OC(C1=CC=C(C(Br)=N1)F)=O
Safety
- RIDADR
- UN2811
- HS Code
- 2933399990
- Storage Class
- 6.1C - Combustible acute toxic Cat.3
toxic compounds or compounds which causing chronic effects - Hazard Classifications
- Acute Tox. 3 Oral
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H301Toxic if swalloed
H311Toxic in contact with skin
H331Toxic if inhaled
H341Suspected of causing genetic defects
- Precautionary statements
-
P201Obtain special instructions before use.
P202Do not handle until all safety precautions have been read and understood.
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P308+P313IF exposed or concerned: Get medical advice/attention.
P310Immediately call a POISON CENTER or doctor/physician.
P330Rinse mouth.
P361Remove/Take off immediately all contaminated clothing.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-B0745
- Product name
- 2-Pyridinecarboxylicacid,6-bromo-5-fluoro-
- Purity
- 99.51%
- Packaging
- 1g
- Price
- $34
- Updated
- 2021/12/16
- Product number
- CAPOB13505
- Product name
- 2-Bromo-3-fluoropyridine-6-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $40
- Updated
- 2021/12/16
- Product number
- 113475
- Product name
- 6-Bromo-5-fluoropyridine-2-carboxylic acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $78
- Updated
- 2021/12/16
- Product number
- PC305018
- Product name
- 6-Bromo-5-fluoropicolinicacid
- Packaging
- 1g
- Price
- $120
- Updated
- 2021/12/16
- Product number
- CS-B0745
- Product name
- 2-Pyridinecarboxylicacid,6-bromo-5-fluoro-
- Purity
- 99.51%
- Packaging
- 5g
- Price
- $142
- Updated
- 2021/12/16
6-Bromo-5-fluoro-2-pyridinecarboxylic acid Chemical Properties,Usage,Production
Synthesis
374633-36-0
1052714-46-1
General procedure for the synthesis of 6-bromo-5-fluoro-2-pyridinecarboxylic acid from 2-bromo-3-fluoro-6-methylpyridine: Potassium permanganate (1.0 eq.) was added to a solution of 2-bromo-3-fluoro-6-methylpyridine (1.0 eq.) in water (30 mL). The reaction mixture was heated at 100 °C for 5 hours and then potassium permanganate (1.0 eq.) was added. After continuing to heat the reaction for 48 hours, the reaction mixture was filtered through a diatomaceous earth pad (4 cm × 2 in.) and washed with deionized water (150 mL). The combined aqueous phases were acidified with 1 N hydrochloric acid to pH = 4 and subsequently extracted with ethyl acetate (200 mL). The organic phase was washed with saturated sodium chloride solution, dried over anhydrous magnesium sulfate, filtered and concentrated to give 6-bromo-5-fluoro-2-pyridinecarboxylic acid in 17% yield as a white solid.LCMS (m/z): 221.9 (MH+); retention time (Rt) = 2.05 min.
References
[1] Patent: US2010/56576, 2010, A1. Location in patent: Page/Page column 46
[2] Patent: WO2012/4217, 2012, A1. Location in patent: Page/Page column 62-63
[3] Patent: WO2012/82689, 2012, A1. Location in patent: Page/Page column 91-92
[4] Patent: US2012/225061, 2012, A1
[5] Patent: US2012/225062, 2012, A1
6-Bromo-5-fluoro-2-pyridinecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-Bromo-5-fluoro-2-pyridinecarboxylic acid manufacturers
- Product
- 6-Bromo-5-fluoro-2-pyridinecarboxylic acid 1052714-46-1
- Price
- US $3.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2019-07-11