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tert-Butyl 6-methylpiperidin-3-ylcarbamate

Product Name
tert-Butyl 6-methylpiperidin-3-ylcarbamate
CAS No.
1150618-39-5
Chemical Name
tert-Butyl 6-methylpiperidin-3-ylcarbamate
Synonyms
EOS-61088;Ritlecitinib Impurity 3;3-(Boc-amino)-6-methylpiperidine;tert-Butyl 6-methylpiperidin-3-ylcarbamate;tert-butyl N-(6-methyl-3-piperidyl)carbamate;tert-butyl N-(6-methylpiperidin-3-yl)carbamate;(6-Methyl-piperidin-3-yl)-carbaMic acid tert-butyl ester;Carbamic acid, N-(6-methyl-3-piperidinyl)-, 1,1-dimethylethyl ester
CBNumber
CB52500611
Molecular Formula
C11H22N2O2
Formula Weight
214.3
MOL File
1150618-39-5.mol
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tert-Butyl 6-methylpiperidin-3-ylcarbamate Property

Density 
1.00
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
Appearance
Light yellow to brown Liquid
InChI
InChI=1S/C11H22N2O2/c1-8-5-6-9(7-12-8)13-10(14)15-11(2,3)4/h8-9,12H,5-7H2,1-4H3,(H,13,14)
InChIKey
NNMBHCRWGGSRBE-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1CCC(C)NC1
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Safety

HS Code 
2933599590
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
T204898
Product name
tert-Butyl(6-Methylpiperidin-3-yl)carbamate
Packaging
50mg
Price
$65
Updated
2021/12/16
TRC
Product number
T204898
Product name
tert-Butyl(6-Methylpiperidin-3-yl)carbamate
Packaging
100mg
Price
$90
Updated
2021/12/16
SynQuest Laboratories
Product number
4H51-1-3V
Product name
tert-Butyl (6-methylpiperidin-3-yl)carbamate
Packaging
1g
Price
$840
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
CHM0077458
Product name
TERT-BUTYL-6-METHYLPIPERIDIN-3-YLCARBAMATE
Purity
95.00%
Packaging
5G
Price
$909.56
Updated
2021/12/16
Apolloscientific
Product number
OR302446
Product name
tert-Butyl (6-methylpiperidin-3-yl)carbamate
Packaging
1g
Price
$709
Updated
2021/12/16
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tert-Butyl 6-methylpiperidin-3-ylcarbamate Chemical Properties,Usage,Production

Synthesis

323578-37-6

1150618-39-5

Step 2. Synthesis of racemic-cis/trans-tert-butyl (6-methylpiperidin-3-yl) carbamate. Platinum(II) oxide (2.5 g) was added to a dry hydrogenation flask under argon protection. Subsequently, a solution of N-Boc-6-methyl-3-aminopyridine (33 g, 158.5 mmol) in acetic acid (300 mL) was added, and the resulting mixture was hydrogenated at 50 °C under 55 psi hydrogen pressure for 30 hours. The reaction was monitored by thin layer chromatography (TLC) (petroleum ether/ethyl acetate, 2:1) to confirm complete consumption of the feedstock. The reaction mixture was filtered and the filter cake was washed with methanol (50 mL x 2). The combined filtrates were concentrated under reduced pressure to afford tert-butyl (6-methylpiperidin-3-yl) carbamate (34 g, 100%) as a yellow oil (cis/trans ratio 2:1), which could be used in the subsequent steps without further purification.LC/MS analysis showed (M+H)+ of 215.2.

References

[1] Patent: US2015/158864, 2015, A1. Location in patent: Paragraph 0270
[2] Patent: WO2010/16005, 2010, A1. Location in patent: Page/Page column 135-136
[3] Patent: WO2016/196776, 2016, A2. Location in patent: Paragraph 001090
[4] Patent: WO2012/148775, 2012, A1. Location in patent: Page/Page column 114

tert-Butyl 6-methylpiperidin-3-ylcarbamate Preparation Products And Raw materials

Raw materials

Preparation Products

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tert-Butyl 6-methylpiperidin-3-ylcarbamate Suppliers

China 59 India 2 United Kingdom 1 United States 5 Global 67
Shanghai Sphchem Co., Ltd.
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Shanghai Synteam Biochem CO.,ltd
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1150618-39-5, tert-Butyl 6-methylpiperidin-3-ylcarbamateRelated Search:

TERT-BUTYL N-[(1-BENZYL-4-PIPERIDINYL)METHYL]CARBAMATE (2-AMINO-4-FLUORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER tert-butyl (pyrrolidin-3-yl)methylcarbamate Carbamic acid, (6-methyl-3-pyridinyl)-, 1,1-dimethylethyl ester (9CI)

  • tert-Butyl 6-methylpiperidin-3-ylcarbamate
  • (6-Methyl-piperidin-3-yl)-carbaMic acid tert-butyl ester
  • tert-butyl N-(6-methyl-3-piperidyl)carbamate
  • EOS-61088
  • Carbamic acid, N-(6-methyl-3-piperidinyl)-, 1,1-dimethylethyl ester
  • 3-(Boc-amino)-6-methylpiperidine
  • Ritlecitinib Impurity 3
  • tert-butyl N-(6-methylpiperidin-3-yl)carbamate
  • 1150618-39-5